STRINGSTRING
STXBP5L STXBP5L TRPV4 TRPV4 PIK3R1 PIK3R1 CSRP3 CSRP3 SIDT2 SIDT2 ZBTB20 ZBTB20 PRKAA2 PRKAA2 PDX1 PDX1 SLC12A6 SLC12A6 APPL2 APPL2 HNF4A HNF4A WISP1 WISP1 GPI GPI SOX4 SOX4 GNB2L1 GNB2L1 ADIPOQ ADIPOQ TRA2B TRA2B CAV3 CAV3 NOX4 NOX4 SLC37A4 SLC37A4 CRY1 CRY1 INSR INSR GAS6 GAS6 HIF1A HIF1A ADRA2A ADRA2A STAT3 STAT3 HECTD4 HECTD4 PTPN11 PTPN11 GCG GCG ADCY8 ADCY8 PRKAA1 PRKAA1 LOC101362469 LOC101362469 PRCP PRCP ALOX5 ALOX5 ADGRF5 ADGRF5 PTPN2 PTPN2 PYGL PYGL LOC101386608 LOC101386608 SIN3A SIN3A RMI1 RMI1 GPR1 GPR1 PTCH1 PTCH1 STXBP3 STXBP3 MCU MCU ADIPOR2 ADIPOR2 LOC101376741 LOC101376741 BACE2 BACE2 PAX6 PAX6 ERN1 ERN1 KLF7 KLF7 NCOA5 NCOA5 LOC101378650 LOC101378650 SUCNR1 SUCNR1 PIK3R2 PIK3R2 GCGR GCGR ASPSCR1 ASPSCR1 RPH3AL RPH3AL INPP5K INPP5K NR1H4 NR1H4 INS INS LOC101371496 LOC101371496 CARTPT CARTPT TFAP2E TFAP2E LRRC8D LRRC8D SLC39A14 SLC39A14 MBD5 MBD5 HK3 HK3 FOXA3 FOXA3 FOXA1 FOXA1 CRY2 CRY2 MLXIPL MLXIPL VGF VGF DHPS DHPS LOC101367833 LOC101367833 HK2 HK2 PLSCR3 PLSCR3 SLC2A4 SLC2A4 PIK3CA PIK3CA RFX6 RFX6 PARK7 PARK7 IL6 IL6 G6PC2 G6PC2 FBN1 FBN1 STK11 STK11 NR1D1 NR1D1 GCKR GCKR GPER1 GPER1 BAD BAD BHLHA15 BHLHA15 FOXK1 FOXK1 PDK4 PDK4 SIRT1 SIRT1 FABP5 FABP5 HKDC1 HKDC1 ADIPOR1 ADIPOR1 LRRC8A LRRC8A PCK1 PCK1 AGER AGER LOC101363381 LOC101363381 KAT5 KAT5 GCK GCK HK1 HK1 TCF7L2 TCF7L2 LOC101372441 LOC101372441 CCDC186 CCDC186 KCNB1 KCNB1 SESN3 SESN3 LEPR LEPR SLC8B1 SLC8B1 IGF1R IGF1R FAM3B FAM3B CSMD2 CSMD2 NUCKS1 NUCKS1 PTPRN2 PTPRN2 FOXK2 FOXK2 PCK2 PCK2 CSMD1 CSMD1 HNF1A HNF1A RAF1 RAF1 NGFR NGFR PDK2 PDK2 CNR1 CNR1 RAB11FIP2 RAB11FIP2 FFAR1 FFAR1 LOC101380768 LOC101380768 FFAR2 FFAR2 WFS1 WFS1 TFAP2B TFAP2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STXBP5LSyntaxin-binding protein 5-like. (719 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
CSRP3Cysteine and glycine-rich protein 3 isoform X1. (194 aa)
SIDT2SID1 transmembrane family member 2. (832 aa)
ZBTB20Zinc finger and BTB domain-containing protein 20 isoform X1. (751 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PDX1Pancreas/duodenum homeobox protein 1. (283 aa)
SLC12A6Solute carrier family 12 member 6 isoform X1. (1150 aa)
APPL2DCC-interacting protein 13-beta. (662 aa)
HNF4AHepatocyte nuclear factor 4-alpha isoform X1. (474 aa)
WISP1WNT1-inducible-signaling pathway protein 1. (369 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (557 aa)
SOX4Transcription factor SOX. (472 aa)
GNB2L1Guanine nucleotide-binding protein subunit beta-2-like 1 isoform X1. (317 aa)
ADIPOQAdiponectin isoform X1. (266 aa)
TRA2BTransformer-2 protein homolog beta isoform X1. (290 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
NOX4NADPH oxidase 4 isoform X1. (578 aa)
SLC37A4Glucose-6-phosphate translocase isoform X1. (451 aa)
CRY1Cryptochrome-1. (534 aa)
INSRTyrosine-protein kinase receptor. (1381 aa)
GAS6Growth arrest-specific protein 6. (674 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (822 aa)
ADRA2Aalpha-2A adrenergic receptor. (465 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
HECTD4Probable E3 ubiquitin-protein ligase HECTD4 isoform X1. (4283 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
GCGGlucagon. (180 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
PRKAA1Non-specific serine/threonine protein kinase. (528 aa)
LOC101362469WD repeat-containing protein 5-like. (465 aa)
PRCPLysosomal Pro-X carboxypeptidase. (497 aa)
ALOX5Arachidonate 5-lipoxygenase isoform X1. (674 aa)
ADGRF5Probable G-protein coupled receptor 116; Belongs to the G-protein coupled receptor 2 family. (1346 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (416 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (851 aa)
LOC101386608Cytochrome b5 reductase 4 isoform X1. (520 aa)
SIN3APaired amphipathic helix protein Sin3a. (1274 aa)
RMI1recQ-mediated genome instability protein 1. (638 aa)
GPR1G-protein coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
PTCH1Protein patched homolog 1 isoform X1. (1452 aa)
STXBP3Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
MCUCalcium uniporter protein, mitochondrial. (284 aa)
ADIPOR2Adiponectin receptor protein 2. (386 aa)
LOC101376741Forkhead box protein O3. (453 aa)
BACE2Beta-secretase 2; Belongs to the peptidase A1 family. (439 aa)
PAX6Paired box protein Pax-6 isoform X1. (436 aa)
ERN1Serine/threonine-protein kinase/endoribonuclease IRE1. (975 aa)
KLF7Krueppel-like factor 7 isoform X1. (302 aa)
NCOA5Nuclear receptor coactivator 5 isoform X1. (579 aa)
LOC101378650Selenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (195 aa)
SUCNR1Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (330 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
GCGRLOW QUALITY PROTEIN: glucagon receptor; Belongs to the G-protein coupled receptor 2 family. (864 aa)
ASPSCR1Tether containing UBX domain for GLUT4. (537 aa)
RPH3ALLOW QUALITY PROTEIN: rab effector Noc2. (370 aa)
INPP5KInositol polyphosphate 5-phosphatase K. (451 aa)
NR1H4Bile acid receptor isoform X1. (486 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
LOC101371496Syntaxin-binding protein 5-like. (464 aa)
CARTPTCocaine- and amphetamine-regulated transcript protein. (116 aa)
TFAP2ETranscription factor AP-2-epsilon. (440 aa)
LRRC8DVolume-regulated anion channel subunit LRRC8D. (856 aa)
SLC39A14Zinc transporter ZIP14 isoform X2. (490 aa)
MBD5methyl-CpG-binding domain protein 5 isoform X1. (1733 aa)
HK3Hexokinase-3. (924 aa)
FOXA3Hepatocyte nuclear factor 3-gamma. (350 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (473 aa)
CRY2Cryptochrome-2. (593 aa)
MLXIPLCarbohydrate-responsive element-binding protein isoform X1. (857 aa)
VGFNeurosecretory protein VGF. (617 aa)
DHPSDeoxyhypusine synthase isoform X1. (369 aa)
LOC101367833Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (501 aa)
HK2Hexokinase-2. (917 aa)
PLSCR3Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (295 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (508 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RFX6DNA-binding protein RFX6. (928 aa)
PARK7Protein deglycase DJ-1. (189 aa)
IL6Interleukin-6 isoform X1. (212 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
FBN1Fibrillin-1. (2868 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (439 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
GCKRLOW QUALITY PROTEIN: glucokinase regulatory protein. (640 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
BADBcl2-associated agonist of cell death. (168 aa)
BHLHA15LOW QUALITY PROTEIN: class A basic helix-loop-helix protein 15. (377 aa)
FOXK1Forkhead box protein K1. (611 aa)
PDK4Protein-serine/threonine kinase. (406 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (740 aa)
FABP5Fatty acid-binding protein, epidermal; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
HKDC1Putative hexokinase HKDC1. (917 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
LRRC8AVolume-regulated anion channel subunit LRRC8A. (810 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1. (622 aa)
AGERAdvanced glycosylation end product-specific receptor isoform X1. (381 aa)
LOC101363381RNA-binding protein 4. (365 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (555 aa)
GCKPhosphotransferase. (458 aa)
HK1Hexokinase-1 isoform X1. (935 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (621 aa)
LOC101372441LOW QUALITY PROTEIN: volume-regulated anion channel subunit LRRC8D-like. (857 aa)
CCDC186Coiled-coil domain-containing protein 186 isoform X1. (925 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
SESN3Sestrin-3 isoform X1. (496 aa)
LEPRLeptin receptor isoform X1. (1166 aa)
SLC8B1Sodium/potassium/calcium exchanger 6, mitochondrial; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (564 aa)
IGF1RTyrosine-protein kinase receptor. (1304 aa)
FAM3BProtein FAM3B. (235 aa)
CSMD2CUB and sushi domain-containing protein 2. (2290 aa)
NUCKS1Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform X1. (248 aa)
PTPRN2Receptor-type tyrosine-protein phosphatase N2. (961 aa)
FOXK2Forkhead box protein K2. (555 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1. (668 aa)
CSMD1CUB and sushi domain-containing protein 1. (3658 aa)
HNF1AHepatocyte nuclear factor 1-alpha isoform X1. (638 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (421 aa)
PDK2Protein-serine/threonine kinase. (423 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (472 aa)
RAB11FIP2Rab11 family-interacting protein 2. (512 aa)
FFAR1Free fatty acid receptor 1. (299 aa)
LOC101380768CUB and sushi domain-containing protein 2. (1352 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (329 aa)
WFS1Wolframin. (889 aa)
TFAP2BTranscription factor AP-2-beta isoform X1. (469 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.