STRINGSTRING
TRAP1 TRAP1 JMJD8 JMJD8 PPIF PPIF LOC101364805 LOC101364805 PNPT1 PNPT1 INS INS PHLDA2 PHLDA2 INPP5K INPP5K GCGR GCGR FLCN FLCN PPP1R3D PPP1R3D PHB2 PHB2 LOC101375770 LOC101375770 PPP1R3A PPP1R3A CDK1 CDK1 IL10RB IL10RB SLC4A1 SLC4A1 AAED1 AAED1 FBP1 FBP1 METTL20 METTL20 HDAC4 HDAC4 NOA1 NOA1 SLC25A23 SLC25A23 ZBTB7A ZBTB7A SIRT6 SIRT6 TIGAR TIGAR TRPV4 TRPV4 DYRK2 DYRK2 IFNLR1 IFNLR1 KHK KHK FAM214A FAM214A PRKCDBP PRKCDBP IGF1 IGF1 DDIT4 DDIT4 PDE12 PDE12 CBFA2T3 CBFA2T3 STOML2 STOML2 EIF6 EIF6 PPP1R3B PPP1R3B LOC101371328 LOC101371328 PASK PASK GCK GCK SPHK2 SPHK2 PPARGC1A PPARGC1A NDUFA4 NDUFA4 APOPT1 APOPT1 AKT1 AKT1 PINK1 PINK1 SLC2A6 SLC2A6 PPP1R3C PPP1R3C IDE IDE P2RX7 P2RX7 NKX1-1 NKX1-1 PRKAG2 PRKAG2 DNAJC15 DNAJC15 AKT2 AKT2 OGT OGT EPM2AIP1 EPM2AIP1 INSR INSR KIAA0226L KIAA0226L HTR2A HTR2A HIF1A HIF1A PPP1R3F PPP1R3F NUPR1 NUPR1 EP300 EP300 PARK7 PARK7 PIK3CA PIK3CA TP53 TP53 MLXIPL MLXIPL TREX1 TREX1 GIT1 GIT1 LOC101370311 LOC101370311 AKT3 AKT3 LOC101380005 LOC101380005 GPD1 GPD1 GLTSCR2 GLTSCR2 ENPP1 ENPP1 PPP1R3G PPP1R3G NCOR1 NCOR1 PRELID1 PRELID1 SHMT2 SHMT2 ZBTB20 ZBTB20 OPN3 OPN3 PPP1R3E PPP1R3E ACTN3 ACTN3 ARL2 ARL2 PTH PTH STAT3 STAT3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRAP1Heat shock protein 75 kDa, mitochondrial isoform X1. (702 aa)
JMJD8jmjC domain-containing protein 8. (277 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (209 aa)
LOC101364805Cytochrome c oxidase copper chaperone. (63 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1, mitochondrial. (784 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PHLDA2Pleckstrin homology-like domain family A member 2. (131 aa)
INPP5KInositol polyphosphate 5-phosphatase K. (451 aa)
GCGRLOW QUALITY PROTEIN: glucagon receptor; Belongs to the G-protein coupled receptor 2 family. (864 aa)
FLCNFolliculin. (579 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (299 aa)
PHB2Prohibitin. (299 aa)
LOC101375770Translational activator of cytochrome c oxidase 1. (298 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1123 aa)
CDK1Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily. (297 aa)
IL10RBInterleukin-10 receptor subunit beta. (375 aa)
SLC4A1Anion exchange protein. (921 aa)
AAED1Thioredoxin-like protein AAED1. (232 aa)
FBP1Fructose-1,6-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
METTL20Protein N-lysine methyltransferase METTL20. (266 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1056 aa)
NOA1Nitric oxide-associated protein 1. (695 aa)
SLC25A23Calcium-binding mitochondrial carrier protein SCaMC-3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (468 aa)
ZBTB7AZinc finger and BTB domain-containing protein 7A. (588 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (359 aa)
TIGARFructose-2,6-bisphosphatase TIGAR. (270 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
DYRK2Dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X1. (601 aa)
IFNLR1Interferon lambda receptor 1. (510 aa)
KHKKetohexokinase isoform X1. (343 aa)
FAM214AProtein FAM214A. (1086 aa)
PRKCDBPProtein kinase C delta-binding protein. (261 aa)
IGF1Insulin-like growth factor I isoform X1. (187 aa)
DDIT4DNA damage-inducible transcript 4 protein. (231 aa)
PDE122',5'-phosphodiesterase 12. (608 aa)
CBFA2T3Protein CBFA2T3. (560 aa)
STOML2Stomatin-like protein 2, mitochondrial isoform X1. (538 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (253 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (339 aa)
LOC101371328LOW QUALITY PROTEIN: folliculin-like. (610 aa)
PASKPAS domain-containing serine/threonine-protein kinase. (1389 aa)
GCKPhosphotransferase. (458 aa)
SPHK2Sphingosine kinase 2 isoform X1. (659 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (803 aa)
NDUFA4Cytochrome c oxidase subunit NDUFA4. (82 aa)
APOPT1Apoptogenic protein 1, mitochondrial. (192 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial. (582 aa)
SLC2A6Solute carrier family 2, facilitated glucose transporter member 6 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
IDEInsulin-degrading enzyme isoform X1; Belongs to the peptidase M16 family. (1019 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (589 aa)
NKX1-1NK1 transcription factor-related protein 1. (402 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2 isoform X1. (569 aa)
DNAJC15dnaJ homolog subfamily C member 15. (149 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
OGTUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1. (1046 aa)
EPM2AIP1EPM2A-interacting protein 1. (608 aa)
INSRTyrosine-protein kinase receptor. (1381 aa)
KIAA0226LUncharacterized protein KIAA0226-like homolog. (654 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (822 aa)
PPP1R3FProtein phosphatase 1 regulatory subunit 3F isoform X1. (813 aa)
NUPR1Nuclear protein 1. (82 aa)
EP300Histone acetyltransferase p300. (2421 aa)
PARK7Protein deglycase DJ-1. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
MLXIPLCarbohydrate-responsive element-binding protein isoform X1. (857 aa)
TREX1Three-prime repair exonuclease 1. (314 aa)
GIT1ARF GTPase-activating protein GIT1 isoform X1. (770 aa)
LOC101370311Cytochrome c oxidase subunit 7A-related protein, mitochondrial. (114 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC101380005Uncharacterized protein C1orf177 homolog. (400 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
GLTSCR2Glioma tumor suppressor candidate region gene 2 protein isoform X1. (499 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (925 aa)
PPP1R3GProtein phosphatase 1 regulatory subunit 3G. (351 aa)
NCOR1Nuclear receptor corepressor 1 isoform X1. (2434 aa)
PRELID1PRELI domain-containing protein 1, mitochondrial isoform X1. (219 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
ZBTB20Zinc finger and BTB domain-containing protein 20 isoform X1. (751 aa)
OPN3Opsin-3; Belongs to the G-protein coupled receptor 1 family. (402 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (277 aa)
ACTN3Alpha-actinin-3 isoform X1. (907 aa)
ARL2ADP-ribosylation factor-like protein 2 isoform X1; Belongs to the small GTPase superfamily. Arf family. (184 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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