STRINGSTRING
HMGN3 HMGN3 PARK2 PARK2 IL6 IL6 CDK16 CDK16 SIRT4 SIRT4 AACS AACS TRH TRH BLK BLK GIP GIP NR1D1 NR1D1 UCN UCN FKBP1B FKBP1B POMC POMC ACVR1C ACVR1C CHGA CHGA SYT9 SYT9 SFRP1 SFRP1 GPR68 GPR68 RAB11FIP1 RAB11FIP1 GPER1 GPER1 FOXO1 FOXO1 TFR2 TFR2 CHD7 CHD7 NLGN2 NLGN2 NMB NMB RFX6 RFX6 LRP5 LRP5 GCK GCK TCF7L2 TCF7L2 PASK PASK KCNB1 KCNB1 FAM3D FAM3D BAD BAD CDV3 CDV3 PLA2G6 PLA2G6 SLC8B1 SLC8B1 SRI SRI MLPH MLPH PPP3CB PPP3CB TMF1 TMF1 GHRL GHRL SLC25A22 SLC25A22 EDN1 EDN1 BAIAP3 BAIAP3 TCIRG1 TCIRG1 ANO1 ANO1 EFNA5 EFNA5 NNAT NNAT GHRH GHRH KDM5B KDM5B LRRC8A LRRC8A STXBP5L STXBP5L SNX4 SNX4 ILDR1 ILDR1 NKX6-1 NKX6-1 SPP1 SPP1 SOX4 SOX4 CRHBP CRHBP C1QTNF3 C1QTNF3 CAPN10 CAPN10 FFAR4 FFAR4 C2CD2L C2CD2L CRY1 CRY1 KCNJ11 KCNJ11 HIF1A HIF1A HTR2C HTR2C ADRA2A ADRA2A INHBA INHBA ADCYAP1 ADCYAP1 CRHR1 CRHR1 C1QTNF6 C1QTNF6 LOC101377813 LOC101377813 PICK1 PICK1 PFKL PFKL SMAD4 SMAD4 PTPN11 PTPN11 GCG GCG ADCY8 ADCY8 GRP GRP ARHGEF7 ARHGEF7 SCG5 SCG5 ALOX5 ALOX5 CFTR CFTR MPC2 MPC2 FAM132A FAM132A MCU MCU SLC25A18 SLC25A18 GPLD1 GPLD1 HFE HFE KLF7 KLF7 CREB1 CREB1 TM7SF3 TM7SF3 TNFSF11 TNFSF11 IL11 IL11 LOC101378650 LOC101378650 INHBB INHBB RPH3AL RPH3AL DOC2B DOC2B NR1H4 NR1H4 SCT SCT LOC101371496 LOC101371496 PRKCE PRKCE RAB11FIP3 RAB11FIP3 CCKAR CCKAR TFAP2E TFAP2E NKX3-1 NKX3-1 SLC9B2 SLC9B2 ABCA12 ABCA12 OSM OSM PLA2G3 PLA2G3 CRY2 CRY2 GHRHR GHRHR HNF4A HNF4A PAX8 PAX8 GALR1 GALR1 PDX1 PDX1 RASL10B RASL10B CCL5 CCL5 SIDT2 SIDT2 TNF TNF VAMP8 VAMP8 STXBP4 STXBP4 NDUFAF2 NDUFAF2 VAMP7 VAMP7 BIRC5 BIRC5 C1QTNF1 C1QTNF1 IFNG IFNG ANXA1 ANXA1 TFAP2B TFAP2B FFAR2 FFAR2 FFAR1 FFAR1 MIDN MIDN ICA1 ICA1 REST REST ADCY5 ADCY5 HNF1A HNF1A LIF LIF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HMGN3High mobility group nucleosome-binding domain-containing protein 3 isoform X1. (171 aa)
PARK2RBR-type E3 ubiquitin transferase. (492 aa)
IL6Interleukin-6 isoform X1. (212 aa)
CDK16Cyclin-dependent kinase 16 isoform X1. (570 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
AACSacetoacetyl-CoA synthetase. (672 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (238 aa)
BLKTyrosine-protein kinase. (500 aa)
GIPGastric inhibitory polypeptide. (145 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
UCNUrocortin. (126 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
POMCPro-opiomelanocortin. (258 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
CHGAchromogranin-A isoform X1. (445 aa)
SYT9Synaptotagmin-9. (552 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
GPR68Ovarian cancer G-protein coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
RAB11FIP1Rab11 family-interacting protein 1 isoform X1. (1270 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
FOXO1Forkhead box protein O1. (662 aa)
TFR2Transferrin receptor protein 2. (805 aa)
CHD7chromodomain-helicase-DNA-binding protein 7. (2999 aa)
NLGN2Neuroligin-2 isoform X1. (835 aa)
NMBneuromedin-B isoform X1. (164 aa)
RFX6DNA-binding protein RFX6. (928 aa)
LRP5Low-density lipoprotein receptor-related protein 5. (1451 aa)
GCKPhosphotransferase. (458 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (621 aa)
PASKPAS domain-containing serine/threonine-protein kinase. (1389 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
FAM3DProtein FAM3D. (224 aa)
BADBcl2-associated agonist of cell death. (168 aa)
CDV3Protein CDV3 homolog isoform X1. (107 aa)
PLA2G685/88 kDa calcium-independent phospholipase A2. (836 aa)
SLC8B1Sodium/potassium/calcium exchanger 6, mitochondrial; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (564 aa)
SRISorcin isoform X1. (212 aa)
MLPHMelanophilin. (454 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
TMF1TATA element modulatory factor. (1045 aa)
GHRLAppetite-regulating hormone isoform X3. (134 aa)
SLC25A22LOW QUALITY PROTEIN: mitochondrial glutamate carrier 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (356 aa)
EDN1Endothelin-1 isoform X1. (227 aa)
BAIAP3BAI1-associated protein 3 isoform X1. (1179 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (828 aa)
ANO1Anoctamin. (978 aa)
EFNA5ephrin-A5; Belongs to the ephrin family. (228 aa)
NNATNeuronatin isoform X1. (128 aa)
GHRHSomatoliberin. (106 aa)
KDM5BLysine-specific demethylase 5B. (1544 aa)
LRRC8AVolume-regulated anion channel subunit LRRC8A. (810 aa)
STXBP5LSyntaxin-binding protein 5-like. (719 aa)
SNX4Sorting nexin-4 isoform X1. (450 aa)
ILDR1Immunoglobulin-like domain-containing receptor 1 isoform X1. (546 aa)
NKX6-1Homeobox protein Nkx-6.1. (368 aa)
SPP1Osteopontin isoform X1. (299 aa)
SOX4Transcription factor SOX. (472 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
C1QTNF3Complement C1q tumor necrosis factor-related protein 3 isoform X1. (319 aa)
CAPN10Calpain-10; Belongs to the peptidase C2 family. (665 aa)
FFAR4Free fatty acid receptor 4 isoform X1. (361 aa)
C2CD2LC2 domain-containing protein 2-like isoform X1. (707 aa)
CRY1Cryptochrome-1. (534 aa)
KCNJ11ATP-sensitive inward rectifier potassium channel 11. (390 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (822 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
ADRA2Aalpha-2A adrenergic receptor. (465 aa)
INHBAInhibin beta A chain. (423 aa)
ADCYAP1Pituitary adenylate cyclase-activating polypeptide. (176 aa)
CRHR1Corticotropin-releasing factor receptor 1 isoform X1; Belongs to the G-protein coupled receptor 2 family. (415 aa)
C1QTNF6Complement C1q tumor necrosis factor-related protein 6. (265 aa)
LOC101377813Vesicle-associated membrane protein 7-like isoform X1; Belongs to the synaptobrevin family. (212 aa)
PICK1PRKCA-binding protein. (417 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
GCGGlucagon. (180 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
GRPGastrin-releasing peptide isoform X1. (139 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7 isoform X1. (805 aa)
SCG5Neuroendocrine protein 7B2 isoform X1. (212 aa)
ALOX5Arachidonate 5-lipoxygenase isoform X1. (674 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1483 aa)
MPC2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (127 aa)
FAM132AAdipolin. (307 aa)
MCUCalcium uniporter protein, mitochondrial. (284 aa)
SLC25A18Mitochondrial glutamate carrier 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (326 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D. (843 aa)
HFEHereditary hemochromatosis protein isoform X1; Belongs to the MHC class I family. (346 aa)
KLF7Krueppel-like factor 7 isoform X1. (302 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
IL11Interleukin-11. (199 aa)
LOC101378650Selenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (195 aa)
INHBBInhibin beta B chain. (320 aa)
RPH3ALLOW QUALITY PROTEIN: rab effector Noc2. (370 aa)
DOC2BDouble C2-like domain-containing protein. (412 aa)
NR1H4Bile acid receptor isoform X1. (486 aa)
SCTSecretin. (130 aa)
LOC101371496Syntaxin-binding protein 5-like. (464 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
RAB11FIP3Rab11 family-interacting protein 3. (734 aa)
CCKARCholecystokinin receptor type A; Belongs to the G-protein coupled receptor 1 family. (428 aa)
TFAP2ETranscription factor AP-2-epsilon. (440 aa)
NKX3-1Homeobox protein Nkx-3.1 isoform X1. (231 aa)
SLC9B2Mitochondrial sodium/hydrogen exchanger 9B2 isoform X1. (537 aa)
ABCA12ATP-binding cassette sub-family A member 12. (2595 aa)
OSMoncostatin-M. (238 aa)
PLA2G3Group 3 secretory phospholipase A2. (522 aa)
CRY2Cryptochrome-2. (593 aa)
GHRHRGrowth hormone-releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
HNF4AHepatocyte nuclear factor 4-alpha isoform X1. (474 aa)
PAX8Paired box protein Pax-8 isoform X1. (458 aa)
GALR1Galanin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (349 aa)
PDX1Pancreas/duodenum homeobox protein 1. (283 aa)
RASL10BRas-like protein family member 10B. (203 aa)
CCL5C-C motif chemokine. (146 aa)
SIDT2SID1 transmembrane family member 2. (832 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
VAMP8Vesicle-associated membrane protein 8. (101 aa)
STXBP4Syntaxin-binding protein 4. (558 aa)
NDUFAF2Mimitin, mitochondrial. (169 aa)
VAMP7Vesicle-associated membrane protein 7 isoform X1; Belongs to the synaptobrevin family. (220 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (142 aa)
C1QTNF1Complement C1q tumor necrosis factor-related protein 1. (279 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
ANXA1Annexin. (345 aa)
TFAP2BTranscription factor AP-2-beta isoform X1. (469 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (329 aa)
FFAR1Free fatty acid receptor 1. (299 aa)
MIDNMidnolin. (504 aa)
ICA1Islet cell autoantigen 1 isoform X1. (509 aa)
RESTRE1-silencing transcription factor. (1000 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
HNF1AHepatocyte nuclear factor 1-alpha isoform X1. (638 aa)
LIFLeukemia inhibitory factor isoform X1. (204 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
Server load: low (40%) [HD]