STRINGSTRING
PTPN11 PTPN11 GPHB5 GPHB5 JAK2 JAK2 LOC101371706 LOC101371706 PTHLH PTHLH JAK3 JAK3 UCN2 UCN2 TYK2 TYK2 LEP LEP NPPC NPPC GNAO1 GNAO1 UCN UCN PTH PTH FABP4 FABP4 LOC105757053 LOC105757053 GNRH2 GNRH2 GNAS GNAS VIP VIP GPHA2 GPHA2 JAK1 JAK1 PSMC5 PSMC5 SOCS2 SOCS2 UCN3 UCN3 ADCYAP1 ADCYAP1 NPPA NPPA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
GPHB5Glycoprotein hormone beta-5. (130 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
LOC101371706Somatotropin isoform X1. (216 aa)
PTHLHParathyroid hormone-related protein. (177 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
UCN2Urocortin-2. (116 aa)
TYK2Tyrosine-protein kinase. (1203 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
NPPCC-type natriuretic peptide. (126 aa)
GNAO1Guanine nucleotide-binding protein G(O) subunit alpha isoform X2. (354 aa)
UCNUrocortin. (126 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
FABP4Fatty acid-binding protein, adipocyte; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
LOC105757053Neuroendocrine secretory protein 55. (246 aa)
GNRH2Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (106 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1015 aa)
VIPVIP peptides isoform X1. (170 aa)
GPHA2Glycoprotein hormone alpha-2. (127 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
PSMC526S protease regulatory subunit 8 isoform X1; Belongs to the AAA ATPase family. (409 aa)
SOCS2LOW QUALITY PROTEIN: suppressor of cytokine signaling 2. (287 aa)
UCN3Urocortin-3. (165 aa)
ADCYAP1Pituitary adenylate cyclase-activating polypeptide. (176 aa)
NPPANatriuretic peptides A. (152 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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