STRINGSTRING
PTPN11 PTPN11 P2RY6 P2RY6 FGF18 FGF18 CCL21 CCL21 GLIPR2 GLIPR2 ABL1 ABL1 CHI3L1 CHI3L1 DSTYK DSTYK NODAL NODAL FGF4 FGF4 GPER1 GPER1 PDGFC PDGFC GAREML GAREML DNAJC27 DNAJC27 PHB PHB HAND2 HAND2 ABCA7 ABCA7 NDRG4 NDRG4 CX3CL1 CX3CL1 CCL17 CCL17 CCL22 CCL22 GPR55 GPR55 HTR2B HTR2B FGFR3 FGFR3 KDR KDR TGFB1 TGFB1 MAPK3 MAPK3 PLA2G5 PLA2G5 FGF1 FGF1 TNFRSF11A TNFRSF11A CIB1 CIB1 ALOX15 ALOX15 FBXW9 FBXW9 CCL26 CCL26 CCL24 CCL24 CRKL CRKL C5AR2 C5AR2 APOE APOE CTGF CTGF PTPN22 PTPN22 RAP1A RAP1A FBXW7 FBXW7 FAM150A FAM150A CD74 CD74 PDGFRB PDGFRB CSF1R CSF1R FSHR FSHR SERPINF2 SERPINF2 LOC101376925 LOC101376925 TNFSF11 TNFSF11 IL26 IL26 CD44 CD44 MAP3K12 MAP3K12 HCRTR1 HCRTR1 HMGB1 HMGB1 PRKCZ PRKCZ AAED1 AAED1 NPTN NPTN SLAMF1 SLAMF1 CXCL17 CXCL17 XCL1 XCL1 NOD2 NOD2 RAMP3 RAMP3 RASGRP1 RASGRP1 PTEN PTEN NOTCH1 NOTCH1 CARD9 CARD9 ADCYAP1 ADCYAP1 PTK2B PTK2B HTR2A HTR2A CCL25 CCL25 GAS6 GAS6 LOC101371529 LOC101371529 LOC101370944 LOC101370944 LOC101371244 LOC101371244 CCL4 CCL4 FFAR4 FFAR4 FLT4 FLT4 NOX4 NOX4 MFHAS1 MFHAS1 FAM150B FAM150B PRKCDBP PRKCDBP F2R F2R F2RL1 F2RL1 PHB2 PHB2 CD4 CD4 NOD1 NOD1 PDGFA PDGFA BMPER BMPER CCL16 CCL16 CCL14 CCL14 JUN JUN FGF21 FGF21 PRKCA PRKCA FGF10 FGF10 FERMT2 FERMT2 FGF23 FGF23 NOTCH2 NOTCH2 TLR4 TLR4 TRPV4 TRPV4 BMP2 BMP2 TEK TEK ACKR3 ACKR3 CCL1 CCL1 LOC101381254 LOC101381254 TREM2 TREM2 LOC101378149 LOC101378149 CCL8 CCL8 TREML1 TREML1 SLC30A10 SLC30A10 PDGFD PDGFD RAPGEF2 RAPGEF2 ST5 ST5 PDGFRA PDGFRA LOC101381638 LOC101381638 SCIMP SCIMP PDGFB PDGFB SPRY2 SPRY2 PRKD2 PRKD2 C5AR1 C5AR1 LOC101371484 LOC101371484 FGFR4 FGFR4 FGF2 FGF2 NPNT NPNT SHC1 SHC1 BMP4 BMP4 THPO THPO SEMA7A SEMA7A SRC SRC APELA APELA LOC105758121 LOC105758121 LOC105758123 LOC105758123 GAREM GAREM OPRM1 OPRM1 BRAF BRAF RIPK2 RIPK2 AGER AGER FGF19 FGF19 CCL20 CCL20 EGFR EGFR PTPRC PTPRC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
P2RY6P2Y purinoceptor 6. (398 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
CCL21C-C motif chemokine 21. (137 aa)
GLIPR2Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family. (154 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
CHI3L1Chitinase-3-like protein 1; Belongs to the glycosyl hydrolase 18 family. (384 aa)
DSTYKDual serine/threonine and tyrosine protein kinase isoform X1. (929 aa)
NODALNodal homolog. (348 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
PDGFCPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
GAREMLGRB2-associated and regulator of MAPK protein-like. (866 aa)
DNAJC27dnaJ homolog subfamily C member 27 isoform X1. (273 aa)
PHBProhibitin. (272 aa)
HAND2Heart- and neural crest derivatives-expressed protein 2. (217 aa)
ABCA7ATP-binding cassette sub-family A member 7. (2140 aa)
NDRG4Protein NDRG4 isoform X1. (371 aa)
CX3CL1Fractalkine. (412 aa)
CCL17C-C motif chemokine 17. (99 aa)
CCL22C-C motif chemokine. (93 aa)
GPR55G-protein coupled receptor 55; Belongs to the G-protein coupled receptor 1 family. (320 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1355 aa)
TGFB1Transforming growth factor beta-1. (287 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PLA2G5Phospholipase A(2). (137 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
TNFRSF11ATumor necrosis factor receptor superfamily member 11A. (784 aa)
CIB1Calcium and integrin-binding protein 1. (191 aa)
ALOX15Arachidonate 15-lipoxygenase. (663 aa)
FBXW9F-box/WD repeat-containing protein 9. (458 aa)
CCL26C-C motif chemokine. (94 aa)
CCL24C-C motif chemokine 24. (119 aa)
CRKLCrk-like protein. (303 aa)
C5AR2C5a anaphylatoxin chemotactic receptor 2. (350 aa)
APOEApolipoprotein E. (329 aa)
CTGFConnective tissue growth factor. (351 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (806 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
FBXW7F-box/WD repeat-containing protein 7 isoform X1. (710 aa)
FAM150AProtein FAM150A. (129 aa)
CD74HLA class II histocompatibility antigen gamma chain. (279 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1098 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (966 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (692 aa)
SERPINF2Alpha-2-antiplasmin isoform X1; Belongs to the serpin family. (491 aa)
LOC101376925G-protein coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (362 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
IL26Interleukin-26. (322 aa)
CD44CD44 antigen. (363 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (892 aa)
HCRTR1Orexin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
HMGB1High mobility group protein B1. (207 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa)
AAED1Thioredoxin-like protein AAED1. (232 aa)
NPTNNeuroplastin isoform X1. (398 aa)
SLAMF1Signaling lymphocytic activation molecule. (338 aa)
CXCL17VEGF coregulated chemokine 1. (119 aa)
XCL1Lymphotactin. (112 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1013 aa)
RAMP3Receptor activity-modifying protein 3. (149 aa)
RASGRP1RAS guanyl-releasing protein 1 isoform X1. (797 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2567 aa)
CARD9Caspase recruitment domain-containing protein 9. (536 aa)
ADCYAP1Pituitary adenylate cyclase-activating polypeptide. (176 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
CCL25C-C motif chemokine 25. (146 aa)
GAS6Growth arrest-specific protein 6. (674 aa)
LOC101371529Regakine-1-like. (107 aa)
LOC101370944C-C motif chemokine. (93 aa)
LOC101371244C-C motif chemokine. (93 aa)
CCL4C-C motif chemokine. (92 aa)
FFAR4Free fatty acid receptor 4 isoform X1. (361 aa)
FLT4Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1450 aa)
NOX4NADPH oxidase 4 isoform X1. (578 aa)
MFHAS1Malignant fibrous histiocytoma-amplified sequence 1 isoform X1. (1052 aa)
FAM150BProtein FAM150B. (150 aa)
PRKCDBPProtein kinase C delta-binding protein. (261 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
F2RL1Proteinase-activated receptor 2. (398 aa)
PHB2Prohibitin. (299 aa)
CD4T-cell surface glycoprotein CD4. (462 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (953 aa)
PDGFAPlatelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (211 aa)
BMPERBMP-binding endothelial regulator protein. (685 aa)
CCL16C-C motif chemokine 16. (108 aa)
CCL14C-C motif chemokine. (134 aa)
JUNTranscription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
FERMT2Fermitin family homolog 2 isoform X1. (687 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (2471 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
TEKAngiopoietin-1 receptor isoform X1. (1125 aa)
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
CCL1C-C motif chemokine 1. (94 aa)
LOC101381254C-C motif chemokine. (149 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (226 aa)
LOC101378149C-C motif chemokine. (98 aa)
CCL8C-C motif chemokine 8. (99 aa)
TREML1Trem-like transcript 1 protein isoform X1. (311 aa)
SLC30A10Zinc transporter 10. (479 aa)
PDGFDPlatelet-derived growth factor D. (328 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2 isoform X1. (1644 aa)
ST5Suppression of tumorigenicity 5 protein isoform X1. (1132 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
LOC101381638Apoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
SCIMPLOW QUALITY PROTEIN: SLP adapter and CSK-interacting membrane protein. (343 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (242 aa)
SPRY2Protein sprouty homolog 2. (315 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (877 aa)
C5AR1C5a anaphylatoxin chemotactic receptor 1; Belongs to the G-protein coupled receptor 1 family. (330 aa)
LOC101371484Receptor tyrosine-protein kinase erbB-4. (838 aa)
FGFR4Fibroblast growth factor receptor. (856 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (377 aa)
NPNTNephronectin isoform X1. (621 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
THPOLOW QUALITY PROTEIN: thrombopoietin. (276 aa)
SEMA7Asemaphorin-7A isoform X1; Belongs to the semaphorin family. (666 aa)
SRCTyrosine-protein kinase. (553 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
LOC105758121C-C motif chemokine 3-like. (137 aa)
LOC105758123C-C motif chemokine 15-like. (112 aa)
GAREMGRB2-associated and regulator of MAPK protein isoform X1. (876 aa)
OPRM1Mu-type opioid receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (403 aa)
BRAFSerine/threonine-protein kinase B-raf. (772 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
AGERAdvanced glycosylation end product-specific receptor isoform X1. (381 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
CCL20C-C motif chemokine. (97 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C. (1302 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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