STRINGSTRING
PLA2G6 PLA2G6 LRP5 LRP5 GCK GCK TCF7L2 TCF7L2 PASK PASK KCNB1 KCNB1 FAM3D FAM3D CDV3 CDV3 SLC8B1 SLC8B1 SRI SRI MLPH MLPH PPP3CB PPP3CB GHRL GHRL SLC25A22 SLC25A22 BAIAP3 BAIAP3 PARK2 PARK2 HMGN3 HMGN3 ADCY5 ADCY5 REST REST ICA1 ICA1 MIDN MIDN FFAR1 FFAR1 FFAR2 FFAR2 TFAP2B TFAP2B IFNG IFNG BIRC5 BIRC5 NDUFAF2 NDUFAF2 STXBP4 STXBP4 TNF TNF SIDT2 SIDT2 CCL5 CCL5 RASL10B RASL10B PDX1 PDX1 PAX8 PAX8 HNF4A HNF4A GHRHR GHRHR SOX4 SOX4 CRHBP CRHBP CAPN10 CAPN10 FFAR4 FFAR4 C2CD2L C2CD2L KCNJ11 KCNJ11 HIF1A HIF1A HTR2C HTR2C ADRA2A ADRA2A ADCYAP1 ADCYAP1 PICK1 PICK1 PFKL PFKL PTPN11 PTPN11 GCG GCG ADCY8 ADCY8 GRP GRP ARHGEF7 ARHGEF7 ALOX5 ALOX5 CFTR CFTR MPC2 MPC2 FAM132A FAM132A MCU MCU SLC25A18 SLC25A18 GPLD1 GPLD1 HFE HFE KLF7 KLF7 TM7SF3 TM7SF3 TNFSF11 TNFSF11 LOC101378650 LOC101378650 INHBB INHBB RPH3AL RPH3AL DOC2B DOC2B NR1H4 NR1H4 SCT SCT LOC101371496 LOC101371496 PRKCE PRKCE TFAP2E TFAP2E SLC9B2 SLC9B2 ABCA12 ABCA12 FOXO1 FOXO1 TFR2 TFR2 CHD7 CHD7 NLGN2 NLGN2 RFX6 RFX6 IL6 IL6 CDK16 CDK16 SIRT4 SIRT4 AACS AACS TRH TRH BLK BLK GIP GIP NR1D1 NR1D1 UCN UCN FKBP1B FKBP1B ACVR1C ACVR1C CHGA CHGA SYT9 SYT9 SFRP1 SFRP1 GPR68 GPR68 GPER1 GPER1 BAD BAD TCIRG1 TCIRG1 ANO1 ANO1 EFNA5 EFNA5 NNAT NNAT GHRH GHRH LRRC8A LRRC8A STXBP5L STXBP5L ILDR1 ILDR1 NKX6-1 NKX6-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLA2G685/88 kDa calcium-independent phospholipase A2. (836 aa)
LRP5Low-density lipoprotein receptor-related protein 5. (1451 aa)
GCKPhosphotransferase. (458 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (621 aa)
PASKPAS domain-containing serine/threonine-protein kinase. (1389 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
FAM3DProtein FAM3D. (224 aa)
CDV3Protein CDV3 homolog isoform X1. (107 aa)
SLC8B1Sodium/potassium/calcium exchanger 6, mitochondrial; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (564 aa)
SRISorcin isoform X1. (212 aa)
MLPHMelanophilin. (454 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
GHRLAppetite-regulating hormone isoform X3. (134 aa)
SLC25A22LOW QUALITY PROTEIN: mitochondrial glutamate carrier 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (356 aa)
BAIAP3BAI1-associated protein 3 isoform X1. (1179 aa)
PARK2RBR-type E3 ubiquitin transferase. (492 aa)
HMGN3High mobility group nucleosome-binding domain-containing protein 3 isoform X1. (171 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
RESTRE1-silencing transcription factor. (1000 aa)
ICA1Islet cell autoantigen 1 isoform X1. (509 aa)
MIDNMidnolin. (504 aa)
FFAR1Free fatty acid receptor 1. (299 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (329 aa)
TFAP2BTranscription factor AP-2-beta isoform X1. (469 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (142 aa)
NDUFAF2Mimitin, mitochondrial. (169 aa)
STXBP4Syntaxin-binding protein 4. (558 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
SIDT2SID1 transmembrane family member 2. (832 aa)
CCL5C-C motif chemokine. (146 aa)
RASL10BRas-like protein family member 10B. (203 aa)
PDX1Pancreas/duodenum homeobox protein 1. (283 aa)
PAX8Paired box protein Pax-8 isoform X1. (458 aa)
HNF4AHepatocyte nuclear factor 4-alpha isoform X1. (474 aa)
GHRHRGrowth hormone-releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
SOX4Transcription factor SOX. (472 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
CAPN10Calpain-10; Belongs to the peptidase C2 family. (665 aa)
FFAR4Free fatty acid receptor 4 isoform X1. (361 aa)
C2CD2LC2 domain-containing protein 2-like isoform X1. (707 aa)
KCNJ11ATP-sensitive inward rectifier potassium channel 11. (390 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (822 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
ADRA2Aalpha-2A adrenergic receptor. (465 aa)
ADCYAP1Pituitary adenylate cyclase-activating polypeptide. (176 aa)
PICK1PRKCA-binding protein. (417 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
GCGGlucagon. (180 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
GRPGastrin-releasing peptide isoform X1. (139 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7 isoform X1. (805 aa)
ALOX5Arachidonate 5-lipoxygenase isoform X1. (674 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1483 aa)
MPC2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (127 aa)
FAM132AAdipolin. (307 aa)
MCUCalcium uniporter protein, mitochondrial. (284 aa)
SLC25A18Mitochondrial glutamate carrier 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (326 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D. (843 aa)
HFEHereditary hemochromatosis protein isoform X1; Belongs to the MHC class I family. (346 aa)
KLF7Krueppel-like factor 7 isoform X1. (302 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
LOC101378650Selenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (195 aa)
INHBBInhibin beta B chain. (320 aa)
RPH3ALLOW QUALITY PROTEIN: rab effector Noc2. (370 aa)
DOC2BDouble C2-like domain-containing protein. (412 aa)
NR1H4Bile acid receptor isoform X1. (486 aa)
SCTSecretin. (130 aa)
LOC101371496Syntaxin-binding protein 5-like. (464 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
TFAP2ETranscription factor AP-2-epsilon. (440 aa)
SLC9B2Mitochondrial sodium/hydrogen exchanger 9B2 isoform X1. (537 aa)
ABCA12ATP-binding cassette sub-family A member 12. (2595 aa)
FOXO1Forkhead box protein O1. (662 aa)
TFR2Transferrin receptor protein 2. (805 aa)
CHD7chromodomain-helicase-DNA-binding protein 7. (2999 aa)
NLGN2Neuroligin-2 isoform X1. (835 aa)
RFX6DNA-binding protein RFX6. (928 aa)
IL6Interleukin-6 isoform X1. (212 aa)
CDK16Cyclin-dependent kinase 16 isoform X1. (570 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
AACSacetoacetyl-CoA synthetase. (672 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (238 aa)
BLKTyrosine-protein kinase. (500 aa)
GIPGastric inhibitory polypeptide. (145 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
UCNUrocortin. (126 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
CHGAchromogranin-A isoform X1. (445 aa)
SYT9Synaptotagmin-9. (552 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
GPR68Ovarian cancer G-protein coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
BADBcl2-associated agonist of cell death. (168 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (828 aa)
ANO1Anoctamin. (978 aa)
EFNA5ephrin-A5; Belongs to the ephrin family. (228 aa)
NNATNeuronatin isoform X1. (128 aa)
GHRHSomatoliberin. (106 aa)
LRRC8AVolume-regulated anion channel subunit LRRC8A. (810 aa)
STXBP5LSyntaxin-binding protein 5-like. (719 aa)
ILDR1Immunoglobulin-like domain-containing receptor 1 isoform X1. (546 aa)
NKX6-1Homeobox protein Nkx-6.1. (368 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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