STRINGSTRING
AQP11 AQP11 ZER1 ZER1 SH3RF1 SH3RF1 PSMF1 PSMF1 TRIB3 TRIB3 ANKIB1 ANKIB1 TMEM130 TMEM130 SMURF1 SMURF1 GNA12 GNA12 PSMC1 PSMC1 PITHD1 PITHD1 MARCH7 MARCH7 RPL11 RPL11 OSBPL7 OSBPL7 GIPC3 GIPC3 SGTA SGTA TMEM259 TMEM259 SIRT6 SIRT6 FZR1 FZR1 BAG5 BAG5 MKRN2 MKRN2 FAM192A FAM192A HERPUD1 HERPUD1 CSNK2A2 CSNK2A2 PRICKLE1 PRICKLE1 UBE2K UBE2K PSMC4 PSMC4 SIRT2 SIRT2 OGT OGT OPHN1 OPHN1 FBXW8 FBXW8 ARAF ARAF RNFT2 RNFT2 CCDC22 CCDC22 ALAD ALAD NUPR1 NUPR1 DESI1 DESI1 PARK7 PARK7 FAM122A FAM122A RNFT1 RNFT1 COMMD1 COMMD1 XPO1 XPO1 RNF14 RNF14 ECSCR ECSCR RFWD2 RFWD2 DDRGK1 DDRGK1 DET1 DET1 USP13 USP13 SH3RF3 SH3RF3 PLK1 PLK1 FBXW9 FBXW9 GIPC1 GIPC1 SMARCC1 SMARCC1 NUDT15 NUDT15 PSMC3 PSMC3 USP9X USP9X RNF185 RNF185 PDCL3 PDCL3 ZYG11A ZYG11A ZYG11B ZYG11B CDC20 CDC20 WNT10B WNT10B WNT1 WNT1 GLTSCR2 GLTSCR2 APOE APOE USP7 USP7 BBS7 BBS7 TRIB2 TRIB2 BTRC BTRC PSME2 PSME2 CCAR2 CCAR2 LRRK2 LRRK2 RNF180 RNF180 RNF19A RNF19A FBXW7 FBXW7 BAG2 BAG2 PSMC2 PSMC2 DNAJB2 DNAJB2 UBQLN4 UBQLN4 GBA GBA EFNA1 EFNA1 AXIN1 AXIN1 SOCS5 SOCS5 GSK3B GSK3B DAB2 DAB2 DYX1C1 DYX1C1 LATS1 LATS1 LOC101366594 LOC101366594 RYBP RYBP DDA1 DDA1 TRIM67 TRIM67 SOCS4 SOCS4 CAMLG CAMLG AXIN2 AXIN2 MDM2 MDM2 RCHY1 RCHY1 RNF19B RNF19B HFE HFE LOC101372008 LOC101372008 UFL1 UFL1 MTM1 MTM1 DVL1 DVL1 EPHA4 EPHA4 AGTPBP1 AGTPBP1 PML PML GSK3A GSK3A FOXF2 FOXF2 CAV1 CAV1 SMAD7 SMAD7 LOC101362469 LOC101362469 NUB1 NUB1 BCAP31 BCAP31 SVIP SVIP PRKCG PRKCG KCNE2 KCNE2 PTEN PTEN NDNL2 NDNL2 LOC101363157 LOC101363157 PSMD14 PSMD14 RNF139 RNF139 TRIB1 TRIB1 GIPC2 GIPC2 PSME3 PSME3 USP25 USP25 LOC101376946 LOC101376946 USP14 USP14 LOC101383423 LOC101383423 LOC101386625 LOC101386625 LOC101386321 LOC101386321 CLUL1 CLUL1 UCHL5 UCHL5 PTK2B PTK2B PBK PBK CLU CLU NKD2 NKD2 TTC36 TTC36 MAPK9 MAPK9 EIF3H EIF3H GNB2L1 GNB2L1 UBXN1 UBXN1 USP5 USP5 KLHL40 KLHL40 HIPK2 HIPK2 FBXO22 FBXO22 N4BP1 N4BP1 TMTC3 TMTC3 LOC101376406 LOC101376406 ARIH1 ARIH1 STYX STYX PSMC6 PSMC6 CDC20B CDC20B TREM2 TREM2 TREML1 TREML1 RNF144A RNF144A AGBL4 AGBL4 WAC WAC CBFA2T3 CBFA2T3 RAD23A RAD23A PABPN1L PABPN1L USP19 USP19 ARIH2 ARIH2 PARK2 PARK2 LOC101366203 LOC101366203 PSME1 PSME1 GLMN GLMN SUFU SUFU LOC101363917 LOC101363917 PKD1 PKD1 TRAF7 TRAF7 HSPA6 HSPA6 RNF217 RNF217 CSNK1D CSNK1D PANO1 PANO1 HSPBP1 HSPBP1 TMF1 TMF1 PSMC5 PSMC5 TLK2 TLK2 RNF144B RNF144B LOC101371722 LOC101371722 DAB2IP DAB2IP FHIT FHIT GABARAPL2 GABARAPL2 PIAS1 PIAS1 PSMD10 PSMD10 SH3RF2 SH3RF2 UBE3A UBE3A HSPA1L HSPA1L BAG6 BAG6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (272 aa)
ZER1Protein zer-1 homolog. (766 aa)
SH3RF1E3 ubiquitin-protein ligase SH3RF1. (872 aa)
PSMF1Proteasome inhibitor PI31 subunit. (271 aa)
TRIB3Tribbles homolog 3. (358 aa)
ANKIB1RBR-type E3 ubiquitin transferase. (1090 aa)
TMEM130Transmembrane protein 130 isoform X1. (435 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12 isoform X1. (382 aa)
PSMC126S protease regulatory subunit 4 isoform X1; Belongs to the AAA ATPase family. (440 aa)
PITHD1PITH domain-containing protein 1. (257 aa)
MARCH7E3 ubiquitin-protein ligase MARCH7 isoform X1. (706 aa)
RPL1160S ribosomal protein L11 isoform X1; Belongs to the universal ribosomal protein uL5 family. (178 aa)
OSBPL7Oxysterol-binding protein; Belongs to the OSBP family. (842 aa)
GIPC3PDZ domain-containing protein GIPC3. (312 aa)
SGTASmall glutamine-rich tetratricopeptide repeat-containing protein alpha. (313 aa)
TMEM259Membralin. (621 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (359 aa)
FZR1Fizzy-related protein homolog isoform X1. (496 aa)
BAG5BAG family molecular chaperone regulator 5. (447 aa)
MKRN2Probable E3 ubiquitin-protein ligase makorin-2 isoform X1. (416 aa)
FAM192AProtein FAM192A. (254 aa)
HERPUD1Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein. (389 aa)
CSNK2A2Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (350 aa)
PRICKLE1Prickle-like protein 1. (832 aa)
UBE2KLOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (269 aa)
PSMC426S protease regulatory subunit 6B isoform X1; Belongs to the AAA ATPase family. (418 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
OGTUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1. (1046 aa)
OPHN1Oligophrenin-1. (803 aa)
FBXW8F-box/WD repeat-containing protein 8 isoform X1. (594 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
RNFT2RING finger and transmembrane domain-containing protein 2. (448 aa)
CCDC22Coiled-coil domain-containing protein 22 isoform X1. (627 aa)
ALADDelta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (330 aa)
NUPR1Nuclear protein 1. (82 aa)
DESI1Desumoylating isopeptidase 1. (168 aa)
PARK7Protein deglycase DJ-1. (189 aa)
FAM122AProtein FAM122A. (287 aa)
RNFT1RING finger and transmembrane domain-containing protein 1. (397 aa)
COMMD1COMM domain-containing protein 1. (188 aa)
XPO1Exportin-1. (1071 aa)
RNF14RBR-type E3 ubiquitin transferase. (474 aa)
ECSCREndothelial cell-specific chemotaxis regulator. (236 aa)
RFWD2E3 ubiquitin-protein ligase RFWD2 isoform X1. (731 aa)
DDRGK1DDRGK domain-containing protein 1. (315 aa)
DET1DET1 homolog. (550 aa)
USP13Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (863 aa)
SH3RF3SH3 domain-containing RING finger protein 3. (878 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
FBXW9F-box/WD repeat-containing protein 9. (458 aa)
GIPC1PDZ domain-containing protein GIPC1. (333 aa)
SMARCC1SWI/SNF complex subunit SMARCC1. (1050 aa)
NUDT15Probable 8-oxo-dGTP diphosphatase NUDT15. (171 aa)
PSMC326S protease regulatory subunit 6A isoform X1; Belongs to the AAA ATPase family. (439 aa)
USP9XProbable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X1; Belongs to the peptidase C19 family. (2576 aa)
RNF185E3 ubiquitin-protein ligase RNF185 isoform X1. (192 aa)
PDCL3Phosducin-like protein 3. (240 aa)
ZYG11AProtein zyg-11 homolog A. (756 aa)
ZYG11BProtein zyg-11 homolog B. (665 aa)
CDC20Cell division cycle protein 20 homolog. (499 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
GLTSCR2Glioma tumor suppressor candidate region gene 2 protein isoform X1. (499 aa)
APOEApolipoprotein E. (329 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7 isoform X2; Belongs to the peptidase C19 family. (1107 aa)
BBS7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
TRIB2Tribbles homolog 2 isoform X1. (343 aa)
BTRCF-box/WD repeat-containing protein 1A isoform X1. (605 aa)
PSME2Proteasome activator complex subunit 2 isoform X1. (239 aa)
CCAR2Cell cycle and apoptosis regulator protein 2 isoform X1. (918 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2 isoform X1. (2526 aa)
RNF180E3 ubiquitin-protein ligase RNF180. (592 aa)
RNF19ARBR-type E3 ubiquitin transferase. (838 aa)
FBXW7F-box/WD repeat-containing protein 7 isoform X1. (710 aa)
BAG2BAG family molecular chaperone regulator 2. (211 aa)
PSMC226S protease regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
DNAJB2dnaJ homolog subfamily B member 2 isoform X1. (325 aa)
UBQLN4Ubiquilin-4 isoform X1. (601 aa)
GBAGlucosylceramidase. (536 aa)
EFNA1ephrin-A1 isoform X1; Belongs to the ephrin family. (206 aa)
AXIN1Axin-1. (867 aa)
SOCS5Suppressor of cytokine signaling 5 isoform X1. (536 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
DAB2Disabled homolog 2 isoform X1. (769 aa)
DYX1C1Dyslexia susceptibility 1 candidate gene 1 protein isoform X1. (420 aa)
LATS1Serine/threonine-protein kinase LATS1. (1133 aa)
LOC101366594Casein kinase I isoform delta-like. (335 aa)
RYBPRING1 and YY1-binding protein. (228 aa)
DDA1DET1- and DDB1-associated protein 1. (102 aa)
TRIM67Tripartite motif-containing protein 67 isoform X1. (779 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
CAMLGCalcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. (296 aa)
AXIN2Axin-2 isoform X1. (842 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
RCHY1RING finger and CHY zinc finger domain-containing protein 1 isoform X1. (261 aa)
RNF19BRBR-type E3 ubiquitin transferase. (734 aa)
HFEHereditary hemochromatosis protein isoform X1; Belongs to the MHC class I family. (346 aa)
LOC101372008Melanoma-associated antigen F1. (325 aa)
UFL1E3 UFM1-protein ligase 1. (793 aa)
MTM1Myotubularin isoform X1. (603 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (693 aa)
EPHA4Ephrin type-A receptor 4 isoform X1. (986 aa)
AGTPBP1Cytosolic carboxypeptidase 1 isoform X1. (1186 aa)
PMLProtein PML. (928 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa)
FOXF2Forkhead box protein F2. (451 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
SMAD7Mothers against decapentaplegic homolog. (434 aa)
LOC101362469WD repeat-containing protein 5-like. (465 aa)
NUB1NEDD8 ultimate buster 1 isoform X1. (640 aa)
BCAP31B-cell receptor-associated protein 31. (246 aa)
SVIPSmall VCP/p97-interacting protein. (77 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
KCNE2Potassium voltage-gated channel subfamily E member 2. (123 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
NDNL2Melanoma-associated antigen G1. (284 aa)
LOC10136315760S ribosomal protein L11-like; Belongs to the universal ribosomal protein uL5 family. (178 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (310 aa)
RNF139E3 ubiquitin-protein ligase RNF139. (664 aa)
TRIB1Tribbles homolog 1. (372 aa)
GIPC2PDZ domain-containing protein GIPC2. (312 aa)
PSME3Proteasome activator complex subunit 3 isoform X1. (315 aa)
USP25Ubiquitin carboxyl-terminal hydrolase 25 isoform X1; Belongs to the peptidase C19 family. (1123 aa)
LOC101376946Casein kinase I isoform epsilon isoform X1; Belongs to the protein kinase superfamily. (416 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (494 aa)
LOC101383423Tripartite motif-containing protein 60-like. (473 aa)
LOC101386625Putative tripartite motif-containing protein 75. (469 aa)
LOC101386321Tripartite motif-containing protein 60-like. (470 aa)
CLUL1Clusterin; Belongs to the clusterin family. (483 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (329 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
PBKLymphokine-activated killer T-cell-originated protein kinase isoform X1. (323 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (444 aa)
NKD2Protein naked cuticle homolog 2. (448 aa)
TTC36Tetratricopeptide repeat protein 36. (189 aa)
MAPK9Mitogen-activated protein kinase. (427 aa)
EIF3HEukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (352 aa)
GNB2L1Guanine nucleotide-binding protein subunit beta-2-like 1 isoform X1. (317 aa)
UBXN1UBX domain-containing protein 1 isoform X1. (296 aa)
USP5Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (891 aa)
KLHL40Kelch-like protein 40. (624 aa)
HIPK2Homeodomain-interacting protein kinase 2 isoform X1. (1195 aa)
FBXO22F-box only protein 22. (408 aa)
N4BP1NEDD4-binding protein 1. (896 aa)
TMTC3Transmembrane and TPR repeat-containing protein 3. (915 aa)
LOC101376406Heat shock 70 kDa protein 1; Belongs to the heat shock protein 70 family. (641 aa)
ARIH1RBR-type E3 ubiquitin transferase. (555 aa)
STYXSerine/threonine/tyrosine-interacting protein. (223 aa)
PSMC626S protease regulatory subunit 10B isoform X1; Belongs to the AAA ATPase family. (403 aa)
CDC20BCell division cycle protein 20 homolog B. (547 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (226 aa)
TREML1Trem-like transcript 1 protein isoform X1. (311 aa)
RNF144ARBR-type E3 ubiquitin transferase. (292 aa)
AGBL4Cytosolic carboxypeptidase 6. (287 aa)
WACWW domain-containing adapter protein with coiled-coil isoform X1. (646 aa)
CBFA2T3Protein CBFA2T3. (560 aa)
RAD23AUV excision repair protein RAD23 homolog A isoform X1. (363 aa)
PABPN1LEmbryonic polyadenylate-binding protein 2. (291 aa)
USP19Ubiquitin carboxyl-terminal hydrolase 19. (1321 aa)
ARIH2RBR-type E3 ubiquitin transferase. (491 aa)
PARK2RBR-type E3 ubiquitin transferase. (492 aa)
LOC101366203Probable ubiquitin carboxyl-terminal hydrolase FAF-X; Belongs to the peptidase C19 family. (2027 aa)
PSME1Proteasome activator complex subunit 1 isoform X1. (249 aa)
GLMNGlomulin isoform X1. (600 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
LOC101363917Uncharacterized protein C16orf96 homolog. (1093 aa)
PKD1Polycystin-1 isoform X1. (4307 aa)
TRAF7E3 ubiquitin-protein ligase TRAF7. (670 aa)
HSPA6LOW QUALITY PROTEIN: heat shock 70 kDa protein 6; Belongs to the heat shock protein 70 family. (688 aa)
RNF217RBR-type E3 ubiquitin transferase. (538 aa)
CSNK1DCasein kinase I isoform delta isoform X1; Belongs to the protein kinase superfamily. (428 aa)
PANO1LOW QUALITY PROTEIN: proapoptotic nucleolar protein 1. (288 aa)
HSPBP1Hsp70-binding protein 1 isoform X1. (408 aa)
TMF1TATA element modulatory factor. (1045 aa)
PSMC526S protease regulatory subunit 8 isoform X1; Belongs to the AAA ATPase family. (409 aa)
TLK2Serine/threonine-protein kinase tousled-like 2 isoform X1. (795 aa)
RNF144BRBR-type E3 ubiquitin transferase. (325 aa)
LOC101371722E3 ubiquitin-protein ligase TRIM39. (488 aa)
DAB2IPLOW QUALITY PROTEIN: disabled homolog 2-interacting protein. (1338 aa)
FHITBis(5'-adenosyl)-triphosphatase. (149 aa)
GABARAPL2Gamma-aminobutyric acid receptor-associated protein-like 2. (117 aa)
PIAS1E3 SUMO-protein ligase PIAS1 isoform X1. (655 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10 isoform X1. (226 aa)
SH3RF2Putative E3 ubiquitin-protein ligase SH3RF2 isoform X1. (739 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (920 aa)
HSPA1LHeat shock 70 kDa protein 1-like isoform X1; Belongs to the heat shock protein 70 family. (661 aa)
BAG6Large proline-rich protein BAG6 isoform X1. (1165 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
Server load: low (14%) [HD]