STRINGSTRING
MORF4L2 MORF4L2 FGF10 FGF10 EGFR EGFR KAT5 KAT5 LOC101365857 LOC101365857 NFRKB NFRKB LOC101362568 LOC101362568 MYC MYC FAM35A FAM35A EYA1 EYA1 LOC101386301 LOC101386301 DDX5 DDX5 CEBPG CEBPG EYA2 EYA2 TMEM161A TMEM161A BABAM1 BABAM1 FAM175A FAM175A EYA4 EYA4 MCRS1 MCRS1 DMAP1 DMAP1 FAM178B FAM178B ZCWPW1 ZCWPW1 SPIRE2 SPIRE2 FXR1 FXR1 BRD8 BRD8 SPIDR SPIDR DTX3L DTX3L PARP9 PARP9 UBE2V2 UBE2V2 FAM168A FAM168A FANCB FANCB ANKRD32 ANKRD32 EP400 EP400 PMAIP1 PMAIP1 BRCC3 BRCC3 ERCC8 ERCC8 TIGAR TIGAR RAD51AP1 RAD51AP1 HELQ HELQ RPS3 RPS3 RNF168 RNF168 ENDOG ENDOG SKIL SKIL PARP1 PARP1 SUV420H1 SUV420H1 RAD9A RAD9A SIRT1 SIRT1 MFSD11 MFSD11 EYA3 EYA3 PLA2R1 PLA2R1 BRE BRE MBTD1 MBTD1 SIRT6 SIRT6 PIAS4 PIAS4 RUVBL1 RUVBL1 PRKDC PRKDC ARID2 ARID2 BCL7A BCL7A WAS WAS DHX9 DHX9 NSMCE1 NSMCE1 INO80E INO80E BCL7C BCL7C FUS FUS ATR ATR LOC101374392 LOC101374392 PCNA PCNA WRAP53 WRAP53 FXR2 FXR2 ZNHIT1 ZNHIT1 CCDC117 CCDC117 INO80 INO80 ATM ATM UIMC1 UIMC1 EPC2 EPC2 TIMELESS TIMELESS LOC101375938 LOC101375938 EPC1 EPC1 FAM178A FAM178A CCAR2 CCAR2 NKX3-1 NKX3-1 MEAF6 MEAF6 PAXIP1 PAXIP1 NSMCE4A NSMCE4A HIC1 HIC1 VPS72 VPS72 POGZ POGZ ING3 ING3 ANKLE1 ANKLE1 SUV420H2 SUV420H2 EEF1E1 EEF1E1 TRIM28 TRIM28 YEATS4 YEATS4 ZNF385A ZNF385A HMGB1 HMGB1 INO80D INO80D LOC101381295 LOC101381295 XRCC1 XRCC1 SPIRE1 SPIRE1 ERCC6 ERCC6 MMS19 MMS19 PRKCG PRKCG TFPT TFPT SPRED1 SPRED1 HDAC10 HDAC10 RNF8 RNF8 PNKP PNKP MRGBP MRGBP BCLAF1 BCLAF1 NACC2 NACC2 ANKRD1 ANKRD1 MAD2L2 MAD2L2 UCHL5 UCHL5 ACTR8 ACTR8 PARP3 PARP3 PBK PBK FBXO18 FBXO18 FOXM1 FOXM1 TTI2 TTI2 WDR48 WDR48 SMCHD1 SMCHD1 LOC101382951 LOC101382951 KHDC3L KHDC3L OOEP OOEP RBBP8 RBBP8 FMR1 FMR1 ING4 ING4 EID3 EID3 LOC101366552 LOC101366552 RUVBL2 RUVBL2 RIF1 RIF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MORF4L2Mortality factor 4-like protein 2. (288 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (555 aa)
LOC101365857LOW QUALITY PROTEIN: uncharacterized protein LOC101365857. (654 aa)
NFRKBNuclear factor related to kappa-B-binding protein isoform X1. (1311 aa)
LOC101362568Inhibitor of growth protein. (249 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
FAM35AProtein FAM35A. (258 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (599 aa)
LOC101386301LOW QUALITY PROTEIN: 40S ribosomal protein S3-like. (378 aa)
DDX5Probable ATP-dependent RNA helicase DDX5 isoform X1; Belongs to the DEAD box helicase family. (614 aa)
CEBPGCCAAT/enhancer-binding protein gamma isoform X1. (212 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (553 aa)
TMEM161ATransmembrane protein 161A isoform X1. (467 aa)
BABAM1BRISC and BRCA1-A complex member 1. (336 aa)
FAM175ABRCA1-A complex subunit Abraxas. (409 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (588 aa)
MCRS1Microspherule protein 1 isoform X1. (507 aa)
DMAP1DNA methyltransferase 1-associated protein 1 isoform X1. (468 aa)
FAM178BProtein FAM178B isoform X1. (642 aa)
ZCWPW1Zinc finger CW-type PWWP domain protein 1. (625 aa)
SPIRE2Protein spire homolog 2. (724 aa)
FXR1Fragile X mental retardation syndrome-related protein 1 isoform X1. (648 aa)
BRD8Bromodomain-containing protein 8 isoform X1. (1221 aa)
SPIDRDNA repair-scaffolding protein. (794 aa)
DTX3LE3 ubiquitin-protein ligase DTX3L. (693 aa)
PARP9LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase 9. (992 aa)
UBE2V2Ubiquitin-conjugating enzyme E2 variant 2 isoform X1. (150 aa)
FAM168AProtein FAM168A isoform X1. (244 aa)
FANCBFanconi anemia group B protein. (864 aa)
ANKRD32Ankyrin repeat domain-containing protein 32 isoform X1. (1057 aa)
EP400E1A-binding protein p400. (3074 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
BRCC3Lys-63-specific deubiquitinase BRCC36. (183 aa)
ERCC8DNA excision repair protein ERCC-8. (396 aa)
TIGARFructose-2,6-bisphosphatase TIGAR. (270 aa)
RAD51AP1RAD51-associated protein 1 isoform X1. (354 aa)
HELQLOW QUALITY PROTEIN: helicase POLQ-like. (1094 aa)
RPS340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (570 aa)
ENDOGEndonuclease. (300 aa)
SKILSki-like protein isoform X2. (690 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
SUV420H1Histone-lysine N-methyltransferase SUV420H1 isoform X1. (935 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (391 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (740 aa)
MFSD11UNC93-like protein MFSD11 isoform X1. (449 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa)
PLA2R1Secretory phospholipase A2 receptor. (1465 aa)
BREBRCA1-A complex subunit BRE isoform X1. (407 aa)
MBTD1MBT domain-containing protein 1. (628 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (359 aa)
PIAS4E3 SUMO-protein ligase PIAS4. (509 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
PRKDCDNA-dependent protein kinase catalytic subunit isoform X1; Belongs to the PI3/PI4-kinase family. (4136 aa)
ARID2AT-rich interactive domain-containing protein 2. (1836 aa)
BCL7AB-cell CLL/lymphoma 7 protein family member A isoform X1. (231 aa)
WASwiskott-Aldrich syndrome protein. (501 aa)
DHX9ATP-dependent RNA helicase A isoform X1. (1277 aa)
NSMCE1Non-structural maintenance of chromosomes element 1 homolog isoform X1. (283 aa)
INO80EINO80 complex subunit E isoform X1. (244 aa)
BCL7CB-cell CLL/lymphoma 7 protein family member C isoform X1. (242 aa)
FUSRNA-binding protein FUS isoform X1. (509 aa)
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2644 aa)
LOC101374392Uncharacterized protein C20orf196 homolog. (206 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
WRAP53Telomerase Cajal body protein 1. (532 aa)
FXR2Fragile X mental retardation syndrome-related protein 2. (673 aa)
ZNHIT1Zinc finger HIT domain-containing protein 1. (154 aa)
CCDC117Coiled-coil domain-containing protein 117 isoform X1. (277 aa)
INO80DNA helicase INO80. (1562 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
UIMC1BRCA1-A complex subunit RAP80. (722 aa)
EPC2Enhancer of polycomb homolog. (807 aa)
TIMELESSProtein timeless homolog. (1207 aa)
LOC101375938CCAAT/enhancer-binding protein gamma-like. (175 aa)
EPC1Enhancer of polycomb homolog. (844 aa)
FAM178AProtein FAM178A. (1171 aa)
CCAR2Cell cycle and apoptosis regulator protein 2 isoform X1. (918 aa)
NKX3-1Homeobox protein Nkx-3.1 isoform X1. (231 aa)
MEAF6Chromatin modification-related protein MEAF6 isoform X1. (201 aa)
PAXIP1PAX-interacting protein 1. (1034 aa)
NSMCE4ANon-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (385 aa)
HIC1Hypermethylated in cancer 1 protein isoform X1. (736 aa)
VPS72Vacuolar protein sorting-associated protein 72 homolog isoform X1. (364 aa)
POGZPogo transposable element with ZNF domain isoform X1. (1414 aa)
ING3Inhibitor of growth protein. (418 aa)
ANKLE1LOW QUALITY PROTEIN: ankyrin repeat and LEM domain-containing protein 1. (672 aa)
SUV420H2Histone-lysine N-methyltransferase SUV420H2. (461 aa)
EEF1E1Eukaryotic translation elongation factor 1 epsilon-1. (174 aa)
TRIM28Transcription intermediary factor 1-beta isoform X1. (834 aa)
YEATS4YEATS domain-containing protein 4 isoform X1. (227 aa)
ZNF385AZinc finger protein 385A isoform X1. (386 aa)
HMGB1High mobility group protein B1. (207 aa)
INO80DINO80 complex subunit D. (1029 aa)
LOC101381295Mitogen-activated protein kinase kinase kinase MLT isoform X1. (800 aa)
XRCC1DNA repair protein XRCC1. (630 aa)
SPIRE1Protein spire homolog 1 isoform X1. (751 aa)
ERCC6DNA excision repair protein ERCC-6. (1482 aa)
MMS19MMS19 nucleotide excision repair protein homolog isoform X1. (1030 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
TFPTTCF3 fusion partner isoform X1. (253 aa)
SPRED1Sprouty-related, EVH1 domain-containing protein 1. (442 aa)
HDAC10Histone deacetylase 10. (670 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (487 aa)
PNKPBifunctional polynucleotide phosphatase/kinase. (521 aa)
MRGBPMRG/MORF4L-binding protein. (202 aa)
BCLAF1Bcl-2-associated transcription factor 1 isoform X1. (921 aa)
NACC2Nucleus accumbens-associated protein 2. (586 aa)
ANKRD1Ankyrin repeat domain-containing protein 1. (319 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (329 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa)
PARP3Poly [ADP-ribose] polymerase. (531 aa)
PBKLymphokine-activated killer T-cell-originated protein kinase isoform X1. (323 aa)
FBXO18F-box only protein 18. (972 aa)
FOXM1Forkhead box protein M1 isoform X1. (763 aa)
TTI2TELO2-interacting protein 2. (508 aa)
WDR48WD repeat-containing protein 48 isoform X1. (677 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1. (2002 aa)
LOC101382951UPF0544 protein C5orf45 homolog. (333 aa)
KHDC3LKHDC3-like protein. (430 aa)
OOEPOocyte-expressed protein homolog. (149 aa)
RBBP8DNA endonuclease RBBP8 isoform X1. (897 aa)
FMR1Fragile X mental retardation protein 1 isoform X1. (632 aa)
ING4Inhibitor of growth protein. (249 aa)
EID3Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (370 aa)
LOC101366552CCAAT/enhancer-binding protein gamma-like. (138 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
RIF1Telomere-associated protein RIF1 isoform X1. (2477 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.