STRINGSTRING
POLD3 POLD3 TERF2 TERF2 ACD ACD DNA2 DNA2 POLA2 POLA2 TEN1 TEN1 RPA3 RPA3 RFC5 RFC5 PCNA PCNA BLM BLM CTC1 CTC1 RFC2 RFC2 RCBTB1 RCBTB1 RCBTB2 RCBTB2 LIG1 LIG1 PRIM1 PRIM1 TINF2 TINF2 PRIM2 PRIM2 TERF1 TERF1 LOC101364320 LOC101364320 WRN WRN FEN1 FEN1 DSCC1 DSCC1 TERF2IP TERF2IP POLD2 POLD2 LOC101375061 LOC101375061 RFC3 RFC3 LOC105757102 LOC105757102 RPA2 RPA2 RFC1 RFC1 OBFC1 OBFC1 CHTF18 CHTF18 RPA1 RPA1 POLD1 POLD1 RPA4 RPA4 RFC4 RFC4 LOC101375641 LOC101375641 POLD4 POLD4 POT1 POT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLD3LOW QUALITY PROTEIN: DNA polymerase delta subunit 3. (470 aa)
TERF2Telomeric repeat-binding factor 2 isoform X1. (542 aa)
ACDAdrenocortical dysplasia protein homolog. (453 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2. (1020 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (595 aa)
TEN1CST complex subunit TEN1. (121 aa)
RPA3Replication protein A 14 kDa subunit. (121 aa)
RFC5Replication factor C subunit 5. (336 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
BLMBloom syndrome protein isoform X1. (1428 aa)
CTC1CST complex subunit CTC1. (1217 aa)
RFC2Replication factor C subunit 2 isoform X1. (368 aa)
RCBTB1RCC1 and BTB domain-containing protein 1. (531 aa)
RCBTB2RCC1 and BTB domain-containing protein 2 isoform X1. (551 aa)
LIG1DNA ligase. (915 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa)
TINF2LOW QUALITY PROTEIN: TERF1-interacting nuclear factor 2. (485 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (509 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (433 aa)
LOC101364320DNA polymerase alpha catalytic subunit-like. (694 aa)
WRNWerner syndrome ATP-dependent helicase. (1405 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
DSCC1Sister chromatid cohesion protein DCC1. (392 aa)
TERF2IPTelomeric repeat-binding factor 2-interacting protein 1. (401 aa)
POLD2DNA polymerase delta subunit 2. (469 aa)
LOC101375061DNA polymerase alpha catalytic subunit-like. (130 aa)
RFC3Replication factor C subunit 3. (356 aa)
LOC105757102Replication factor C subunit 5-like. (84 aa)
RPA2Replication protein A 32 kDa subunit isoform X1. (278 aa)
RFC1Replication factor C subunit 1. (1154 aa)
OBFC1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (396 aa)
CHTF18Chromosome transmission fidelity protein 18 homolog isoform X1. (1011 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
POLD1DNA polymerase. (1107 aa)
RPA4Replication protein A 30 kDa subunit. (244 aa)
RFC4Replication factor C subunit 4. (424 aa)
LOC101375641DNA polymerase alpha catalytic subunit-like. (340 aa)
POLD4DNA polymerase delta subunit 4 isoform X1. (191 aa)
POT1Protection of telomeres protein 1. (653 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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