STRINGSTRING
CASS4 CASS4 HRAS HRAS CRK CRK PIK3R2 PIK3R2 SOS1 SOS1 PTPN11 PTPN11 STAT5A STAT5A STAT3 STAT3 LOC101378783 LOC101378783 NCK2 NCK2 BCAR1 BCAR1 PIK3CB PIK3CB PDGFA PDGFA LOC101367134 LOC101367134 PIK3R1 PIK3R1 RASA1 RASA1 PDGFRA PDGFRA PDGFB PDGFB NRAS NRAS NEDD9 NEDD9 PDGFRB PDGFRB EFS EFS STAT6 STAT6 CRKL CRKL FNDC3A FNDC3A PIK3CA PIK3CA ERAS ERAS GRB7 GRB7 GRB2 GRB2 FNDC3B FNDC3B CSDE1 CSDE1 STAT1 STAT1 RAPGEF1 RAPGEF1 LOC101374328 LOC101374328 SRC SRC STAT5B STAT5B PLCG1 PLCG1 KRAS KRAS NCK1 NCK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CASS4Cas scaffolding protein family member 4. (805 aa)
HRASGTPase HRas isoform X1. (189 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
LOC101378783Fibronectin type III domain containing protein 3C1-like. (1383 aa)
NCK2Cytoplasmic protein. (380 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1 isoform X2. (865 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PDGFAPlatelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (211 aa)
LOC101367134GTPase HRas-like. (177 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
RASA1Ras GTPase-activating protein 1. (1039 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (242 aa)
NRASGTPase NRas. (189 aa)
NEDD9Enhancer of filamentation 1. (834 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1098 aa)
EFSEmbryonal Fyn-associated substrate isoform X1. (561 aa)
STAT6Signal transducer and activator of transcription. (844 aa)
CRKLCrk-like protein. (303 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1199 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ERASGTPase ERas. (233 aa)
GRB7Growth factor receptor-bound protein 7 isoform X1. (530 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1208 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (852 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1270 aa)
LOC101374328Tyrosine-protein phosphatase non-receptor type 11-like. (581 aa)
SRCTyrosine-protein kinase. (553 aa)
STAT5BSignal transducer and activator of transcription. (818 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
KRASGTPase KRas isoform X1. (227 aa)
NCK1Cytoplasmic protein. (377 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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