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SPP1 SPP1 COL3A1 COL3A1 COL5A2 COL5A2 FNDC3B FNDC3B PDGFC PDGFC GRB2 GRB2 GRB7 GRB7 COL2A1 COL2A1 ERAS ERAS FURIN FURIN PIK3CA PIK3CA FNDC3A FNDC3A THBS1 THBS1 CRKL CRKL STAT6 STAT6 EFS EFS PDGFRB PDGFRB THBS3 THBS3 NEDD9 NEDD9 HRAS HRAS CRK CRK PIK3R2 PIK3R2 THBS4 THBS4 SOS1 SOS1 COL9A3 COL9A3 PTPN11 PTPN11 STAT5A STAT5A STAT3 STAT3 COL6A1 COL6A1 LOC101378783 LOC101378783 NCK2 NCK2 BCAR1 BCAR1 PIK3CB PIK3CB THBS2 THBS2 PDGFA PDGFA LOC101367134 LOC101367134 PLAT PLAT PIK3R1 PIK3R1 RASA1 RASA1 PDGFD PDGFD PCSK4 PCSK4 PDGFRA PDGFRA PDGFB PDGFB COL5A3 COL5A3 NRAS NRAS CSDE1 CSDE1 STAT1 STAT1 PLG PLG RAPGEF1 RAPGEF1 LOC101374328 LOC101374328 SRC SRC STAT5B STAT5B PLCG1 PLCG1 KRAS KRAS PTPN12 PTPN12 NCK1 NCK1 CASS4 CASS4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPP1Osteopontin isoform X1. (299 aa)
COL3A1Collagen alpha-1(III) chain. (1466 aa)
COL5A2Collagen alpha-2(V) chain. (1499 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1208 aa)
PDGFCPlatelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
GRB7Growth factor receptor-bound protein 7 isoform X1. (530 aa)
COL2A1Collagen alpha-1(II) chain. (1487 aa)
ERASGTPase ERas. (233 aa)
FURINFurin; Belongs to the peptidase S8 family. (792 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1199 aa)
THBS1Thrombospondin-1 isoform X1. (1170 aa)
CRKLCrk-like protein. (303 aa)
STAT6Signal transducer and activator of transcription. (844 aa)
EFSEmbryonal Fyn-associated substrate isoform X1. (561 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1098 aa)
THBS3Thrombospondin-3 isoform X1. (956 aa)
NEDD9Enhancer of filamentation 1. (834 aa)
HRASGTPase HRas isoform X1. (189 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
THBS4Thrombospondin-4 isoform X1. (961 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
COL9A3Collagen alpha-3(IX) chain. (686 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
COL6A1Collagen alpha-1(VI) chain. (1027 aa)
LOC101378783Fibronectin type III domain containing protein 3C1-like. (1383 aa)
NCK2Cytoplasmic protein. (380 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1 isoform X2. (865 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
THBS2Thrombospondin-2. (1172 aa)
PDGFAPlatelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (211 aa)
LOC101367134GTPase HRas-like. (177 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (560 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
RASA1Ras GTPase-activating protein 1. (1039 aa)
PDGFDPlatelet-derived growth factor D. (328 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (773 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (242 aa)
COL5A3Collagen alpha-3(V) chain isoform X1. (1749 aa)
NRASGTPase NRas. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (852 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (812 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1270 aa)
LOC101374328Tyrosine-protein phosphatase non-receptor type 11-like. (581 aa)
SRCTyrosine-protein kinase. (553 aa)
STAT5BSignal transducer and activator of transcription. (818 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
KRASGTPase KRas isoform X1. (227 aa)
PTPN12Tyrosine-protein phosphatase non-receptor type 12 isoform X1. (783 aa)
NCK1Cytoplasmic protein. (377 aa)
CASS4Cas scaffolding protein family member 4. (805 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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