STRINGSTRING
GRB2 GRB2 RPS6KA4 RPS6KA4 FOSL1 FOSL1 RRAD RRAD NAB1 NAB1 CLTA CLTA RALGDS RALGDS ELK1 ELK1 SHC4 SHC4 RALA RALA SHC2 SHC2 MAP2K2 MAP2K2 ID3 ID3 RPS6KA1 RPS6KA1 PPP4R4 PPP4R4 SH3GL2 SH3GL2 PPP2R1A PPP2R1A PPP4R1 PPP4R1 BRAF BRAF PPP2R1B PPP2R1B LOC101371942 LOC101371942 ASCL1 ASCL1 KRAS KRAS DUSP7 DUSP7 PPP2R5D PPP2R5D EGR2 EGR2 MAPK7 MAPK7 SHC1 SHC1 RAPGEF1 RAPGEF1 RPS6KA2 RPS6KA2 AP2S1 AP2S1 CSDE1 CSDE1 NRAS NRAS ATF1 ATF1 FNBP4 FNBP4 CLTC CLTC MAPKAPK2 MAPKAPK2 LOC101377300 LOC101377300 PIK3R1 PIK3R1 RIT2 RIT2 LOC101367134 LOC101367134 DUSP6 DUSP6 AP2B1 AP2B1 MAP2K1 MAP2K1 YWHAB YWHAB CHD4 CHD4 LOC101381905 LOC101381905 PIK3CB PIK3CB MAP2K5 MAP2K5 RPS6KA5 RPS6KA5 DNAL4 DNAL4 TRIB1 TRIB1 SOS1 SOS1 VRK3 VRK3 AP2A1 AP2A1 SHC3 SHC3 MAPK14 MAPK14 IRS1 IRS1 MAPK11 MAPK11 IRS2 IRS2 DUSP4 DUSP4 PPP2CB PPP2CB SRF SRF DUSP3 DUSP3 AP2M1 AP2M1 ID4 ID4 FRS2 FRS2 ARC ARC PPP2CA PPP2CA CREB1 CREB1 RALB RALB JUND JUND PIK3R2 PIK3R2 CRK CRK ASCL2 ASCL2 HRAS HRAS AP2A2 AP2A2 RIT1 RIT1 NTRK1 NTRK1 EGR3 EGR3 ID2 ID2 KIDINS220 KIDINS220 NAB2 NAB2 TRIB2 TRIB2 RPS6KA3 RPS6KA3 RAP1A RAP1A NGF NGF SGK1 SGK1 NKPD1 NKPD1 FOSB FOSB MAPK15 MAPK15 CRKL CRKL MAPK1 MAPK1 MAPKAPK3 MAPKAPK3 LOC101378833 LOC101378833 LYL1 LYL1 JUNB JUNB EGR4 EGR4 PIK3CA PIK3CA KIAA1468 KIAA1468 EGR1 EGR1 MAPK3 MAPK3 ERAS ERAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
RPS6KA4Ribosomal protein S6 kinase. (772 aa)
FOSL1Fos-related antigen 1 isoform X1. (270 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
NAB1NGFI-A-binding protein 1. (486 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
RALGDSRal guanine nucleotide dissociation stimulator isoform X1. (888 aa)
ELK1ETS domain-containing protein Elk-1. (435 aa)
SHC4SHC-transforming protein 4. (630 aa)
RALARas-related protein Ral-A. (206 aa)
SHC2SHC-transforming protein 2. (586 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ID3DNA-binding protein inhibitor ID-3. (119 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4. (873 aa)
SH3GL2endophilin-A1 isoform X1. (317 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1. (590 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1. (936 aa)
BRAFSerine/threonine-protein kinase B-raf. (772 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1. (694 aa)
LOC101371942AP-2 complex subunit beta-like. (176 aa)
ASCL1Achaete-scute homolog 1. (227 aa)
KRASGTPase KRas isoform X1. (227 aa)
DUSP7Dual specificity protein phosphatase 7 isoform X1. (427 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (678 aa)
EGR2E3 SUMO-protein ligase EGR2 isoform X1. (484 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (806 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1270 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (144 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (852 aa)
NRASGTPase NRas. (189 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1 isoform X1. (286 aa)
FNBP4Formin-binding protein 4 isoform X1. (1021 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
MAPKAPK2MAP kinase-activated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. (402 aa)
LOC101377300Serine/threonine-protein phosphatase 4 regulatory subunit 1-like. (889 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
RIT2GTP-binding protein Rit2. (148 aa)
LOC101367134GTPase HRas-like. (177 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
AP2B1AP complex subunit beta. (951 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
YWHAB14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (244 aa)
CHD4chromodomain-helicase-DNA-binding protein 4 isoform X1. (1912 aa)
LOC101381905Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (218 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAP2K5Dual specificity mitogen-activated protein kinase kinase 5 isoform X1; Belongs to the protein kinase superfamily. (448 aa)
RPS6KA5Ribosomal protein S6 kinase. (798 aa)
DNAL4Dynein light chain. (105 aa)
TRIB1Tribbles homolog 1. (372 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
VRK3Inactive serine/threonine-protein kinase VRK3. (489 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (978 aa)
SHC3SHC-transforming protein 3. (587 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IRS1Insulin receptor substrate 1. (1233 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
IRS2Insulin receptor substrate 2. (1327 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
SRFSerum response factor isoform X1. (508 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
AP2M1AP-2 complex subunit mu isoform X1; Belongs to the adaptor complexes medium subunit family. (435 aa)
ID4DNA-binding protein inhibitor ID-4. (161 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
ARCActivity-regulated cytoskeleton-associated protein. (396 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
RALBRas-related protein Ral-B. (206 aa)
JUNDLOW QUALITY PROTEIN: transcription factor jun-D. (464 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
ASCL2Achaete-scute homolog 2. (194 aa)
HRASGTPase HRas isoform X1. (189 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (936 aa)
RIT1GTP-binding protein Rit1. (219 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
EGR3Early growth response protein 3 isoform X1. (387 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
KIDINS220Kinase D-interacting substrate of 220 kDa isoform X1. (1772 aa)
NAB2NGFI-A-binding protein 2. (525 aa)
TRIB2Tribbles homolog 2 isoform X1. (343 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
NKPD1NTPase KAP family P-loop domain-containing protein 1. (830 aa)
FOSBProtein fosB isoform X1. (338 aa)
MAPK15Mitogen-activated protein kinase. (559 aa)
CRKLCrk-like protein. (303 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
MAPKAPK3MAP kinase-activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
LOC101378833Insulin receptor substrate 2-like. (528 aa)
LYL1Protein lyl-1. (279 aa)
JUNBTranscription factor jun-B. (347 aa)
EGR4Early growth response protein 4 isoform X1. (587 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
KIAA1468lisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X2. (1214 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ERASGTPase ERas. (233 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
Server load: low (34%) [HD]