STRINGSTRING
LOC101367134 LOC101367134 NEDD9 NEDD9 PDPK1 PDPK1 MLST8 MLST8 SHE SHE EFS EFS NRP1 NRP1 ROCK2 ROCK2 LOC101372085 LOC101372085 LOC101373722 LOC101373722 STX7 STX7 CALM3 CALM3 AKT3 AKT3 TENM1 TENM1 PAK3 PAK3 FNDC3A FNDC3A PGF PGF MAPKAPK3 MAPKAPK3 NCF1 NCF1 HSPB1 HSPB1 PRKACA PRKACA HRAS HRAS RICTOR RICTOR ABI1 ABI1 CRK CRK THEM4 THEM4 BAIAP2 BAIAP2 HSH2D HSH2D PIK3R2 PIK3R2 CYFIP2 CYFIP2 CYFIP1 CYFIP1 ELMO2 ELMO2 VAV3 VAV3 PTK2 PTK2 VEGFC VEGFC WASF1 WASF1 FYN FYN PRKCZ PRKCZ NRP2 NRP2 CAV1 CAV1 ACTBL2 ACTBL2 PRKCB PRKCB RNF222 RNF222 PIK3CA PIK3CA ACTL8 ACTL8 SZRD1 SZRD1 NCF2 NCF2 ERAS ERAS PXN PXN AKT2 AKT2 AXL AXL KDR KDR AKT1 AKT1 SHC2 SHC2 SHD SHD WASF2 WASF2 STX12 STX12 CALM1 CALM1 ACTB ACTB VEGFB VEGFB CDH5 CDH5 FNDC3B FNDC3B ELMO3 ELMO3 TRIB3 TRIB3 BRK1 BRK1 NCKAP1 NCKAP1 ITGAV ITGAV SHB SHB TENM2 TENM2 LOC101364731 LOC101364731 PAK2 PAK2 PAK1 PAK1 CTNND1 CTNND1 MAPK11 MAPK11 MAPK12 MAPK12 MAPK13 MAPK13 MAPK14 MAPK14 SRMS SRMS PTK6 PTK6 JUP JUP NCF4 NCF4 ITGB3 ITGB3 MTOR MTOR LOC101378783 LOC101378783 VAV2 VAV2 PTK2B PTK2B CDC42 CDC42 CALML3 CALML3 NCK2 NCK2 FLT4 FLT4 BCAR1 BCAR1 PIK3CB PIK3CB PRKACB PRKACB WASF3 WASF3 FLT1 FLT1 ARVCF ARVCF CALM2 CALM2 FIGF FIGF TENM3 TENM3 PRKCA PRKCA TGFB1I1 TGFB1I1 PIK3R1 PIK3R1 PRR5 PRR5 RASA1 RASA1 MAPKAPK2 MAPKAPK2 CTNNB1 CTNNB1 SPHK1 SPHK1 VAV1 VAV1 TENM4 TENM4 NRAS NRAS CSDE1 CSDE1 MAPKAP1 MAPKAP1 SH2D2A SH2D2A NCKAP1L NCKAP1L ABI2 ABI2 SRC SRC VEGFA VEGFA SHF SHF NOS3 NOS3 LPXN LPXN LOC101377814 LOC101377814 ROCK1 ROCK1 PLCG1 PLCG1 PRKCD PRKCD KRAS KRAS ELMO1 ELMO1 NCK1 NCK1 CASS4 CASS4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101367134GTPase HRas-like. (177 aa)
NEDD9Enhancer of filamentation 1. (834 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
MLST8Target of rapamycin complex subunit LST8. (326 aa)
SHESH2 domain-containing adapter protein E. (477 aa)
EFSEmbryonal Fyn-associated substrate isoform X1. (561 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
LOC101372085calmodulin-A-like; Belongs to the calmodulin family. (271 aa)
LOC101373722Calmodulin-alpha-like; Belongs to the calmodulin family. (149 aa)
STX7Syntaxin-7; Belongs to the syntaxin family. (261 aa)
CALM3Calmodulin isoform X2; Belongs to the calmodulin family. (149 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TENM1Teneurin-1 isoform X1. (2732 aa)
PAK3Serine/threonine-protein kinase PAK 3 isoform X1. (580 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1199 aa)
PGFPlacenta growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
MAPKAPK3MAP kinase-activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
NCF1Neutrophil cytosol factor 1. (501 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (207 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
HRASGTPase HRas isoform X1. (189 aa)
RICTORRapamycin-insensitive companion of mTOR isoform X1. (1732 aa)
ABI1Abl interactor 1 isoform X1. (507 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
THEM4Acyl-coenzyme A thioesterase THEM4. (259 aa)
BAIAP2Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1. (522 aa)
HSH2DHematopoietic SH2 domain-containing protein. (360 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
ELMO2Engulfment and cell motility protein 2 isoform X1. (732 aa)
VAV3Guanine nucleotide exchange factor VAV3 isoform X1. (875 aa)
PTK2Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1052 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (421 aa)
WASF1wiskott-Aldrich syndrome protein family member 1 isoform X1. (559 aa)
FYNTyrosine-protein kinase. (537 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
ACTBL2Beta-actin-like protein 2 isoform X1. (376 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
RNF222RING finger protein 222. (206 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (366 aa)
SZRD1SUZ domain-containing protein 1. (133 aa)
NCF2Neutrophil cytosol factor 2 isoform X1. (526 aa)
ERASGTPase ERas. (233 aa)
PXNPaxillin; Belongs to the paxillin family. (557 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
AXLTyrosine-protein kinase receptor UFO isoform X1. (887 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1355 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SHC2SHC-transforming protein 2. (586 aa)
SHDSH2 domain-containing adapter protein D. (341 aa)
WASF2wiskott-Aldrich syndrome protein family member 2. (498 aa)
STX12Syntaxin-12; Belongs to the syntaxin family. (274 aa)
CALM1Calmodulin isoform X1; Belongs to the calmodulin family. (155 aa)
ACTBActin, cytoplasmic 1 isoform X2. (375 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (188 aa)
CDH5Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (792 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1208 aa)
ELMO3Engulfment and cell motility protein 3 isoform X1. (720 aa)
TRIB3Tribbles homolog 3. (358 aa)
BRK1LOW QUALITY PROTEIN: protein BRICK1. (112 aa)
NCKAP1Nck-associated protein 1 isoform X1. (1134 aa)
ITGAVIntegrin alpha-V isoform X1; Belongs to the integrin alpha chain family. (1053 aa)
SHBSH2 domain-containing adapter protein B. (508 aa)
TENM2Teneurin-2 isoform X1. (2774 aa)
LOC101364731Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
PAK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
CTNND1Catenin delta-1 isoform X1. (1022 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
SRMSTyrosine-protein kinase. (493 aa)
PTK6Tyrosine-protein kinase. (451 aa)
JUPJunction plakoglobin. (744 aa)
NCF4Neutrophil cytosol factor 4. (339 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2559 aa)
LOC101378783Fibronectin type III domain containing protein 3C1-like. (1383 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (878 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
CDC42Cell division control protein 42 homolog isoform X1. (191 aa)
CALML3Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
NCK2Cytoplasmic protein. (380 aa)
FLT4Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1450 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1 isoform X2. (865 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (358 aa)
WASF3wiskott-Aldrich syndrome protein family member 3. (467 aa)
FLT1Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
ARVCFArmadillo repeat protein deleted in velo-cardio-facial syndrome. (960 aa)
CALM2Calmodulin isoform X1; Belongs to the calmodulin family. (155 aa)
FIGFVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (353 aa)
TENM3Teneurin-3. (2699 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Belongs to the paxillin family. (461 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
PRR5Proline-rich protein 5. (389 aa)
RASA1Ras GTPase-activating protein 1. (1039 aa)
MAPKAPK2MAP kinase-activated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. (402 aa)
CTNNB1Catenin beta-1 isoform X1. (781 aa)
SPHK1Sphingosine kinase 1 isoform X1. (487 aa)
VAV1Proto-oncogene vav isoform X1. (864 aa)
TENM4Teneurin-4. (2769 aa)
NRASGTPase NRas. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (852 aa)
MAPKAP1Target of rapamycin complex 2 subunit MAPKAP1 isoform X1. (522 aa)
SH2D2ASH2 domain-containing protein 2A isoform X1. (431 aa)
NCKAP1LNck-associated protein 1-like. (1134 aa)
ABI2Abl interactor 2 isoform X1. (542 aa)
SRCTyrosine-protein kinase. (553 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (587 aa)
SHFSH2 domain-containing adapter protein F isoform X1. (489 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1208 aa)
LPXNLeupaxin isoform X1; Belongs to the paxillin family. (415 aa)
LOC101377814LOW QUALITY PROTEIN: uncharacterized protein LOC101377814. (388 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
KRASGTPase KRas isoform X1. (227 aa)
ELMO1Engulfment and cell motility protein 1 isoform X1. (742 aa)
NCK1Cytoplasmic protein. (377 aa)
CASS4Cas scaffolding protein family member 4. (805 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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