STRINGSTRING
FGF2 FGF2 IL33 IL33 WDR64 WDR64 PPP4R1 PPP4R1 PPP2R1A PPP2R1A FGF19 FGF19 EGFR EGFR BANK1 BANK1 RHOG RHOG CD86 CD86 GAB2 GAB2 FGF18 FGF18 PIP5KL1 PIP5KL1 FAM102A FAM102A BTC BTC EPGN EPGN AREG AREG PIP4K2A PIP4K2A TRIB3 TRIB3 PHLPP2 PHLPP2 FNDC3B FNDC3B HGF HGF FGF4 FGF4 PPP2R5B PPP2R5B FGF3 FGF3 GRB2 GRB2 FGFR1 FGFR1 PPP4R4 PPP4R4 ERBB2 ERBB2 PIP4K2B PIP4K2B FGF22 FGF22 AKT1 AKT1 IRAK4 IRAK4 KLB KLB FGFR3 FGFR3 AKT2 AKT2 MAPK3 MAPK3 PIP5K1B PIP5K1B PIK3CD PIK3CD HBEGF HBEGF NRG2 NRG2 FGF1 FGF1 KIAA1468 KIAA1468 PHLPP1 PHLPP1 PIK3CA PIK3CA SPEM1 SPEM1 LOC101369007 LOC101369007 TGFA TGFA LOC101378833 LOC101378833 FNDC3A FNDC3A AKT3 AKT3 MAPK1 MAPK1 PIK3R3 PIK3R3 STRN4 STRN4 FGF9 FGF9 ERBB3 ERBB3 PIP4K2C PIP4K2C FGF8 FGF8 FGF17 FGF17 IL1RL1 IL1RL1 PDGFRB PDGFRB INS INS THEM4 THEM4 PIK3R2 PIK3R2 LOC101384913 LOC101384913 PPP2CA PPP2CA FRS2 FRS2 FYN FYN GAB1 GAB1 FAM102B FAM102B FGF5 FGF5 ICOS ICOS CD28 CD28 CD276 CD276 LRRC40 LRRC40 PPP2CB PPP2CB MET MET IER3 IER3 IRAK1 IRAK1 ESR2 ESR2 TRAF6 TRAF6 PIK3AP1 PIK3AP1 FGF20 FGF20 IRS2 IRS2 NRG3 NRG3 PTEN PTEN IRS1 IRS1 FLT3LG FLT3LG STRN STRN SRMS SRMS PTK6 PTK6 PTPN11 PTPN11 RAC2 RAC2 LOC101378783 LOC101378783 NRG1 NRG1 INSR INSR MYD88 MYD88 PIK3CB PIK3CB PDGFA PDGFA PPP2R5A PPP2R5A FLT3 FLT3 KITLG KITLG FGF16 FGF16 INSC INSC FGF10 FGF10 KL KL FGF6 FGF6 FGF23 FGF23 PIK3R1 PIK3R1 LOC101377300 LOC101377300 PIP5K1C PIP5K1C VAV1 VAV1 PPP2R5C PPP2R5C PDGFRA PDGFRA FGF7 FGF7 CD19 CD19 KIT KIT PDGFB PDGFB FNBP4 FNBP4 STRN3 STRN3 LOC101371484 LOC101371484 FGFR4 FGFR4 FGFR2 FGFR2 ESR1 ESR1 PIP5K1A PIP5K1A EREG EREG LOC101374328 LOC101374328 LOC101371432 LOC101371432 SRC SRC PPP2R5D PPP2R5D PPP2R5E PPP2R5E EGF EGF IL1RAP IL1RAP PPP2R1B PPP2R1B NRG4 NRG4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (377 aa)
IL33Interleukin-33. (267 aa)
WDR64WD repeat-containing protein 64. (1090 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1. (936 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1. (590 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
BANK1B-cell scaffold protein with ankyrin repeats. (778 aa)
RHOGRho-related GTP-binding protein RhoG. (191 aa)
CD86T-lymphocyte activation antigen CD86 isoform X1. (316 aa)
GAB2GRB2-associated-binding protein 2. (677 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PIP5KL1Phosphatidylinositol 4-phosphate 5-kinase-like protein 1. (396 aa)
FAM102AProtein FAM102A. (379 aa)
BTCProbetacellulin. (178 aa)
EPGNEpigen isoform X1. (153 aa)
AREGAmphiregulin isoform X1. (253 aa)
PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alpha. (406 aa)
TRIB3Tribbles homolog 3. (358 aa)
PHLPP2PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1. (1351 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1208 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4. (873 aa)
ERBB2Receptor protein-tyrosine kinase. (1281 aa)
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (416 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
KLBBeta-klotho. (1037 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1. (540 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform isoform X1. (847 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
KIAA1468lisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X2. (1214 aa)
PHLPP1PH domain leucine-rich repeat-containing protein phosphatase 1. (1687 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SPEM1Spermatid maturation protein 1. (311 aa)
LOC101369007Uncharacterized protein C17orf74 homolog. (480 aa)
TGFAProtransforming growth factor alpha isoform X1. (160 aa)
LOC101378833Insulin receptor substrate 2-like. (528 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1199 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
STRN4Striatin-4 isoform X1. (759 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1339 aa)
PIP4K2CPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1. (421 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
IL1RL1Interleukin-1 receptor-like 1. (556 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1098 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
THEM4Acyl-coenzyme A thioesterase THEM4. (259 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
LOC101384913Receptor tyrosine-protein kinase erbB-4. (479 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
FYNTyrosine-protein kinase. (537 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (724 aa)
FAM102BProtein FAM102B. (361 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
ICOSInducible T-cell costimulator. (209 aa)
CD28T-cell-specific surface glycoprotein CD28. (221 aa)
CD276CD276 antigen isoform X1. (536 aa)
LRRC40Leucine-rich repeat-containing protein 40. (601 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
METHepatocyte growth factor receptor. (1382 aa)
IER3Radiation-inducible immediate-early gene IEX-1. (156 aa)
IRAK1Interleukin-1 receptor-associated kinase 1 isoform X1. (724 aa)
ESR2Estrogen receptor beta isoform X1. (549 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
PIK3AP1Phosphoinositide 3-kinase adapter protein 1. (835 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
IRS2Insulin receptor substrate 2. (1327 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform isoform X1. (722 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
IRS1Insulin receptor substrate 1. (1233 aa)
FLT3LGFms-related tyrosine kinase 3 ligand. (294 aa)
STRNStriatin. (780 aa)
SRMSTyrosine-protein kinase. (493 aa)
PTK6Tyrosine-protein kinase. (451 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
LOC101378783Fibronectin type III domain containing protein 3C1-like. (1383 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform isoform X1. (855 aa)
INSRTyrosine-protein kinase receptor. (1381 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PDGFAPlatelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (211 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
INSCProtein inscuteable homolog isoform X1. (579 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
KLKlotho. (1010 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
LOC101377300Serine/threonine-protein phosphatase 4 regulatory subunit 1-like. (889 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1. (661 aa)
VAV1Proto-oncogene vav isoform X1. (864 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (558 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
CD19B-lymphocyte antigen CD19 isoform X1. (561 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (982 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (242 aa)
FNBP4Formin-binding protein 4 isoform X1. (1021 aa)
STRN3Striatin-3 isoform X1. (750 aa)
LOC101371484Receptor tyrosine-protein kinase erbB-4. (838 aa)
FGFR4Fibroblast growth factor receptor. (856 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (597 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1. (582 aa)
EREGProepiregulin isoform X1. (166 aa)
LOC101374328Tyrosine-protein phosphatase non-receptor type 11-like. (581 aa)
LOC101371432T-cell receptor-associated transmembrane adapter 1. (217 aa)
SRCTyrosine-protein kinase. (553 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (678 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1210 aa)
IL1RAPInterleukin-1 receptor accessory protein. (687 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1. (694 aa)
NRG4Pro-neuregulin-4, membrane-bound isoform. (131 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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