STRINGSTRING
PTPRZ1 PTPRZ1 JAK3 JAK3 PIK3R2 PIK3R2 HDAC1 HDAC1 PLCG1 PLCG1 SHC1 SHC1 STAT3 STAT3 PIK3CB PIK3CB MYCN MYCN PIK3R1 PIK3R1 PTN PTN LOC101379690 LOC101379690 PTPN6 PTPN6 ALK ALK EP300 EP300 HDAC3 HDAC3 PRDM1 PRDM1 ROS1 ROS1 HDAC2 HDAC2 PIK3CA PIK3CA MDK MDK LTK LTK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPRZ1Receptor-type tyrosine-protein phosphatase zeta isoform X1. (2325 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
MYCNN-myc proto-oncogene protein. (464 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
PTNPleiotrophin isoform X1. (168 aa)
LOC101379690Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (427 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
ALKTyrosine-protein kinase receptor. (1196 aa)
EP300Histone acetyltransferase p300. (2421 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
PRDM1PR domain zinc finger protein 1 isoform X3. (818 aa)
ROS1Tyrosine-protein kinase receptor. (2360 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MDKMidkine isoform X1. (143 aa)
LTKLOW QUALITY PROTEIN: leukocyte tyrosine kinase receptor. (837 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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