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CFL2 CFL2 PAK1 PAK1 PLCG2 PLCG2 NCKAP1 NCKAP1 ABL1 ABL1 MYO1B MYO1B BRK1 BRK1 ARPC4 ARPC4 PLD1 PLD1 ELMO3 ELMO3 CFL1 CFL1 ACTB ACTB ARPC1A ARPC1A ARPC1B ARPC1B GRB2 GRB2 PPAPDC1B PPAPDC1B WASF2 WASF2 FGR FGR WIPF2 WIPF2 ARPC3 ARPC3 PLD3 PLD3 MYO5A MYO5A MYO5C MYO5C WAS WAS ACTL8 ACTL8 MAPK3 MAPK3 ACTR2 ACTR2 PIK3CA PIK3CA PLD2 PLD2 LIMK1 LIMK1 NCKIPSD NCKIPSD MYO1D MYO1D NF2 NF2 MAPK1 MAPK1 MYO1A MYO1A ARPC2 ARPC2 PRKCE PRKCE ABI1 ABI1 PPAPDC1A PPAPDC1A MYO1C MYO1C CRK CRK LOC101381082 LOC101381082 BAIAP2 BAIAP2 MYO9B MYO9B PIK3R2 PIK3R2 CYFIP2 CYFIP2 URB2 URB2 CYFIP1 CYFIP1 ELMO2 ELMO2 VAV3 VAV3 PTK2 PTK2 WASF1 WASF1 FYN FYN HSP90AB1 HSP90AB1 MYO10 MYO10 ACTBL2 ACTBL2 ACTR3B ACTR3B WIPF1 WIPF1 SYK SYK SRMS SRMS PTK6 PTK6 ACTR3 ACTR3 VAV2 VAV2 CDC42 CDC42 LOC101373485 LOC101373485 DSTN DSTN LOC101370467 LOC101370467 PIK3CB PIK3CB LYN LYN WASF3 WASF3 CD3G CD3G PLD5 PLD5 PIK3R1 PIK3R1 FMN2 FMN2 LOC101371979 LOC101371979 HSP90AA1 HSP90AA1 ARPC5L ARPC5L VAV1 VAV1 PLD4 PLD4 ARPC5 ARPC5 LOC101365594 LOC101365594 LOC101367061 LOC101367061 LOC101382618 LOC101382618 LOC101366585 LOC101366585 LOC101369822 LOC101369822 FCGR2B FCGR2B LOC101363133 LOC101363133 WASL WASL NCKAP1L NCKAP1L ABI2 ABI2 SRC SRC CD247 CD247 LOC101381301 LOC101381301 FMN1 FMN1 LOC101377814 LOC101377814 PLA2G6 PLA2G6 PLCG1 PLCG1 PRKCD PRKCD WIPF3 WIPF3 ELMO1 ELMO1 NCK1 NCK1 MYO1G MYO1G LOC101363200 LOC101363200 LOC101380000 LOC101380000 BTK BTK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CFL2Cofilin-2 isoform X1; Belongs to the actin-binding proteins ADF family. (166 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
NCKAP1Nck-associated protein 1 isoform X1. (1134 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
MYO1BUnconventional myosin-Ib; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1136 aa)
BRK1LOW QUALITY PROTEIN: protein BRICK1. (112 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (186 aa)
PLD1Phospholipase. (1074 aa)
ELMO3Engulfment and cell motility protein 3 isoform X1. (720 aa)
CFL1Cofilin-1 isoform X1; Belongs to the actin-binding proteins ADF family. (219 aa)
ACTBActin, cytoplasmic 1 isoform X2. (375 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
ARPC1BActin-related protein 2/3 complex subunit 1B. (344 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
PPAPDC1BPhosphatidate phosphatase PPAPDC1B. (261 aa)
WASF2wiskott-Aldrich syndrome protein family member 2. (498 aa)
FGRTyrosine-protein kinase. (526 aa)
WIPF2WAS/WASL-interacting protein family member 2. (440 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
PLD3Phospholipase D3. (490 aa)
MYO5AUnconventional myosin-Va isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1855 aa)
MYO5CUnconventional myosin-Vc; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1742 aa)
WASwiskott-Aldrich syndrome protein. (501 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (366 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PLD2Phospholipase. (933 aa)
LIMK1LIM domain kinase 1 isoform X1. (647 aa)
NCKIPSDNCK-interacting protein with SH3 domain isoform X1. (730 aa)
MYO1DUnconventional myosin-Id; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1006 aa)
NF2Merlin isoform X1. (596 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
MYO1AUnconventional myosin-Ia; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1042 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
ABI1Abl interactor 1 isoform X1. (507 aa)
PPAPDC1APhosphatidate phosphatase PPAPDC1A isoform X1. (271 aa)
MYO1CUnconventional myosin-Ic isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1063 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
LOC101381082High affinity immunoglobulin gamma Fc receptor I. (350 aa)
BAIAP2Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1. (522 aa)
MYO9BUnconventional myosin-IXb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2158 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
URB2Unhealthy ribosome biogenesis protein 2 homolog. (1521 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
ELMO2Engulfment and cell motility protein 2 isoform X1. (732 aa)
VAV3Guanine nucleotide exchange factor VAV3 isoform X1. (875 aa)
PTK2Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1052 aa)
WASF1wiskott-Aldrich syndrome protein family member 1 isoform X1. (559 aa)
FYNTyrosine-protein kinase. (537 aa)
HSP90AB1Heat shock protein HSP 90-beta isoform X1. (720 aa)
MYO10Unconventional myosin-X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2048 aa)
ACTBL2Beta-actin-like protein 2 isoform X1. (376 aa)
ACTR3BActin-related protein 3B isoform X1; Belongs to the actin family. (418 aa)
WIPF1WAS/WASL-interacting protein family member 1. (490 aa)
SYKTyrosine-protein kinase. (635 aa)
SRMSTyrosine-protein kinase. (493 aa)
PTK6Tyrosine-protein kinase. (451 aa)
ACTR3Actin-related protein 3 isoform X1; Belongs to the actin family. (418 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (878 aa)
CDC42Cell division control protein 42 homolog isoform X1. (191 aa)
LOC101373485WAS protein family homolog 1. (472 aa)
DSTNDestrin; Belongs to the actin-binding proteins ADF family. (165 aa)
LOC101370467Uncharacterized protein LOC101370467. (276 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
LYNTyrosine-protein kinase. (512 aa)
WASF3wiskott-Aldrich syndrome protein family member 3. (467 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain isoform X1. (180 aa)
PLD5Inactive phospholipase D5 isoform X1. (474 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
FMN2Formin-2. (1508 aa)
LOC101371979Immunoglobulin iota chain-like. (135 aa)
HSP90AA1LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha. (682 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (243 aa)
VAV1Proto-oncogene vav isoform X1. (864 aa)
PLD4Phospholipase D4 isoform X1. (488 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (154 aa)
LOC101365594Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (167 aa)
LOC101367061LOW QUALITY PROTEIN: uncharacterized protein LOC101367061. (492 aa)
LOC101382618Ig lambda chain V-I region BL2. (234 aa)
LOC101366585Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
LOC101369822Uncharacterized protein LOC101369822. (257 aa)
FCGR2BLow affinity immunoglobulin gamma Fc region receptor II-b isoform X1. (314 aa)
LOC101363133Low affinity immunoglobulin gamma Fc region receptor III-B-like isoform X1. (249 aa)
WASLNeural Wiskott-Aldrich syndrome protein isoform X1. (519 aa)
NCKAP1LNck-associated protein 1-like. (1134 aa)
ABI2Abl interactor 2 isoform X1. (542 aa)
SRCTyrosine-protein kinase. (553 aa)
CD247T-cell surface glycoprotein CD3 zeta chain. (185 aa)
LOC101381301LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like. (732 aa)
FMN1Formin-1 isoform X1. (1420 aa)
LOC101377814LOW QUALITY PROTEIN: uncharacterized protein LOC101377814. (388 aa)
PLA2G685/88 kDa calcium-independent phospholipase A2. (836 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
WIPF3WAS/WASL-interacting protein family member 3. (1048 aa)
ELMO1Engulfment and cell motility protein 1 isoform X1. (742 aa)
NCK1Cytoplasmic protein. (377 aa)
MYO1GUnconventional myosin-Ig; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1018 aa)
LOC101363200Immunoglobulin omega chain-like. (158 aa)
LOC101380000LOW QUALITY PROTEIN: uncharacterized protein LOC101380000. (353 aa)
BTKTyrosine-protein kinase. (687 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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