STRINGSTRING
GAB2 GAB2 FGF4 FGF4 IRS4 IRS4 FGF9 FGF9 FGF8 FGF8 FGF17 FGF17 PDPK1 PDPK1 IGF2 IGF2 THEM4 THEM4 PIK3R2 PIK3R2 CILP2 CILP2 FRS2 FRS2 GAB1 GAB1 FGF5 FGF5 CILP CILP FGF20 FGF20 IRS2 IRS2 IRS1 IRS1 FLT3LG FLT3LG SOS1 SOS1 PTPN11 PTPN11 IGF1 IGF1 PIK3CB PIK3CB FLT3 FLT3 FGF16 FGF16 PIK3C3 PIK3C3 FGF10 FGF10 KL KL FGF6 FGF6 FGF23 FGF23 PIK3R1 PIK3R1 FGF7 FGF7 FGFR4 FGFR4 FGF2 FGF2 FGFR2 FGFR2 SHC1 SHC1 IGF1R IGF1R LOC101374328 LOC101374328 LOC101370160 LOC101370160 PDE3B PDE3B PIK3R4 PIK3R4 FGF19 FGF19 TRIB3 TRIB3 FGF18 FGF18 LOC101369007 LOC101369007 SPEM1 SPEM1 LOC101378833 LOC101378833 PIK3CA PIK3CA FGF1 FGF1 FGFR3 FGFR3 KLB KLB FGF22 FGF22 FGFR1 FGFR1 GRB2 GRB2 FGF3 FGF3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GAB2GRB2-associated-binding protein 2. (677 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
IRS4LOW QUALITY PROTEIN: insulin receptor substrate 4. (1307 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
IGF2LOW QUALITY PROTEIN: insulin-like growth factor II. (198 aa)
THEM4Acyl-coenzyme A thioesterase THEM4. (259 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
CILP2Cartilage intermediate layer protein 2. (1157 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (724 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
CILPCartilage intermediate layer protein 1. (1193 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
IRS2Insulin receptor substrate 2. (1327 aa)
IRS1Insulin receptor substrate 1. (1233 aa)
FLT3LGFms-related tyrosine kinase 3 ligand. (294 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
IGF1Insulin-like growth factor I isoform X1. (187 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
KLKlotho. (1010 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGFR4Fibroblast growth factor receptor. (856 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (377 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
IGF1RTyrosine-protein kinase receptor. (1304 aa)
LOC101374328Tyrosine-protein phosphatase non-receptor type 11-like. (581 aa)
LOC101370160Toll-like receptor 9 isoform X1. (1056 aa)
PDE3BPhosphodiesterase. (1112 aa)
PIK3R4Phosphoinositide 3-kinase regulatory subunit 4. (1358 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
TRIB3Tribbles homolog 3. (358 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
LOC101369007Uncharacterized protein C17orf74 homolog. (480 aa)
SPEM1Spermatid maturation protein 1. (311 aa)
LOC101378833Insulin receptor substrate 2-like. (528 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
KLBBeta-klotho. (1037 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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