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TNFAIP2 TNFAIP2 EXOC4 EXOC4 LEP LEP SEC11A SEC11A EXOC6B EXOC6B ATP6AP2 ATP6AP2 GPR119 GPR119 LOC101370875 LOC101370875 EXOC6 EXOC6 MLPH MLPH LOC101371706 LOC101371706 LOC101377413 LOC101377413 LOC101382544 LOC101382544 PAX6 PAX6 SPCS3 SPCS3 PCSK1 PCSK1 ENPEP ENPEP ALX3 ALX3 MMEL1 MMEL1 LOC101380707 LOC101380707 MBOAT4 MBOAT4 PLA2G7 PLA2G7 CPB2 CPB2 SLC30A4 SLC30A4 DPP8 DPP8 GRP GRP SEC11C SEC11C FAP FAP GCG GCG DPP4 DPP4 ISL1 ISL1 DPP10 DPP10 CPE CPE INHBA INHBA PHEX PHEX SPCS1 SPCS1 EXOC3 EXOC3 CGA CGA GHRL GHRL CPA6 CPA6 KIF5C KIF5C EXOC3L2 EXOC3L2 ACHE ACHE DPP9 DPP9 EXOC7 EXOC7 CPO CPO FFAR1 FFAR1 CDX4 CDX4 LOC101381046 LOC101381046 TSHB TSHB SLC30A7 SLC30A7 INHBC INHBC INHBE INHBE LOC101371794 LOC101371794 ACE2 ACE2 LOC101370515 LOC101370515 CTSG CTSG LOC101383301 LOC101383301 CDX1 CDX1 INHA INHA GNG13 GNG13 PDIA2 PDIA2 SLC30A5 SLC30A5 DPP6 DPP6 SLC30A6 SLC30A6 CTSD CTSD INS INS P4HB P4HB TMEM27 TMEM27 LOC101369994 LOC101369994 CDX2 CDX2 ISL2 ISL2 GNB3 GNB3 INHBB INHBB CTSZ CTSZ ERO1LB ERO1LB EXOC2 EXOC2 SLC30A8 SLC30A8 IGF1 IGF1 LOC101369871 LOC101369871 FFAR4 FFAR4 PCSK2 PCSK2 MYRIP MYRIP AGT AGT EXOC8 EXOC8 EXOC5 EXOC5 MME MME CPA3 CPA3 CPB1 CPB1 SPCS2 SPCS2 REN REN BCHE BCHE EXOC3L1 EXOC3L1 GNAT3 GNAT3 POMC POMC GIP GIP EXOC3L4 EXOC3L4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNFAIP2Tumor necrosis factor alpha-induced protein 2. (651 aa)
EXOC4Exocyst complex component 4 isoform X1. (975 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
SEC11ASignal peptidase complex catalytic subunit SEC11. (179 aa)
EXOC6BExocyst complex component; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (811 aa)
ATP6AP2Renin receptor isoform X1. (351 aa)
GPR119Glucose-dependent insulinotropic receptor; Belongs to the G-protein coupled receptor 1 family. (336 aa)
LOC101370875Dipeptidyl aminopeptidase-like protein 6. (216 aa)
EXOC6Exocyst complex component; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (810 aa)
MLPHMelanophilin. (454 aa)
LOC101371706Somatotropin isoform X1. (216 aa)
LOC101377413Angiotensin-converting enzyme. (1312 aa)
LOC101382544Angiotensin-converting enzyme. (772 aa)
PAX6Paired box protein Pax-6 isoform X1. (436 aa)
SPCS3Signal peptidase complex subunit 3. (180 aa)
PCSK1Neuroendocrine convertase 1; Belongs to the peptidase S8 family. (753 aa)
ENPEPAminopeptidase. (945 aa)
ALX3Homeobox protein aristaless-like 3. (343 aa)
MMEL1Membrane metallo-endopeptidase-like 1. (780 aa)
LOC101380707Aminopeptidase O isoform X1. (819 aa)
MBOAT4Ghrelin O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (435 aa)
PLA2G7Platelet-activating factor acetylhydrolase. (440 aa)
CPB2Carboxypeptidase B2. (423 aa)
SLC30A4Zinc transporter 4. (428 aa)
DPP8Dipeptidyl peptidase 8 isoform X1; Belongs to the peptidase S9B family. (903 aa)
GRPGastrin-releasing peptide isoform X1. (139 aa)
SEC11CSignal peptidase complex catalytic subunit SEC11. (192 aa)
FAPProlyl endopeptidase FAP isoform X1; Belongs to the peptidase S9B family. (760 aa)
GCGGlucagon. (180 aa)
DPP4Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (794 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
DPP10Inactive dipeptidyl peptidase 10; Belongs to the peptidase S9B family. (800 aa)
CPECarboxypeptidase E. (476 aa)
INHBAInhibin beta A chain. (423 aa)
PHEXPhosphate-regulating neutral endopeptidase isoform X1. (749 aa)
SPCS1Signal peptidase complex subunit 1. (162 aa)
EXOC3Exocyst complex component 3. (745 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
GHRLAppetite-regulating hormone isoform X3. (134 aa)
CPA6Carboxypeptidase A6. (393 aa)
KIF5CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (957 aa)
EXOC3L2Exocyst complex component 3-like protein 2. (648 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (652 aa)
DPP9Dipeptidyl peptidase 9 isoform X1; Belongs to the peptidase S9B family. (956 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (763 aa)
CPOLOW QUALITY PROTEIN: carboxypeptidase O. (375 aa)
FFAR1Free fatty acid receptor 1. (299 aa)
CDX4Homeobox protein CDX-4. (284 aa)
LOC101381046Exocyst complex component 1 isoform X1. (894 aa)
TSHBThyrotropin subunit beta. (158 aa)
SLC30A7Zinc transporter 7. (376 aa)
INHBCInhibin beta C chain. (352 aa)
INHBEInhibin beta E chain. (351 aa)
LOC101371794Chymase isoform X1; Belongs to the peptidase S1 family. (247 aa)
ACE2Angiotensin-converting enzyme. (732 aa)
LOC101370515Granzyme B; Belongs to the peptidase S1 family. (249 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (251 aa)
LOC101383301Duodenase-1-like; Belongs to the peptidase S1 family. (252 aa)
CDX1Homeobox protein CDX-1. (264 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (368 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
PDIA2Protein disulfide-isomerase A2. (524 aa)
SLC30A5Zinc transporter 5. (773 aa)
DPP6Dipeptidyl aminopeptidase-like protein 6; Belongs to the peptidase S9B family. (656 aa)
SLC30A6Zinc transporter 6 isoform X1. (461 aa)
CTSDCathepsin D isoform X1; Belongs to the peptidase A1 family. (410 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
P4HBProtein disulfide-isomerase. (510 aa)
TMEM27Collectrin. (160 aa)
LOC101369994Lutropin subunit beta. (141 aa)
CDX2Homeobox protein CDX-2 isoform X1. (311 aa)
ISL2Insulin gene enhancer protein ISL-2. (359 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
INHBBInhibin beta B chain. (320 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (303 aa)
ERO1LBERO1-like protein beta. (467 aa)
EXOC2Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (924 aa)
SLC30A8Zinc transporter 8. (369 aa)
IGF1Insulin-like growth factor I isoform X1. (187 aa)
LOC101369871Follitropin subunit beta. (129 aa)
FFAR4Free fatty acid receptor 4 isoform X1. (361 aa)
PCSK2Neuroendocrine convertase 2 isoform X1; Belongs to the peptidase S8 family. (638 aa)
MYRIPRab effector MyRIP. (857 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
EXOC8Exocyst complex component 8. (725 aa)
EXOC5Exocyst complex component 5 isoform X1. (708 aa)
MMENeprilysin. (749 aa)
CPA3Mast cell carboxypeptidase A isoform X1. (417 aa)
CPB1Carboxypeptidase B. (417 aa)
SPCS2Signal peptidase complex subunit 2. (226 aa)
RENRenin; Belongs to the peptidase A1 family. (404 aa)
BCHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (621 aa)
EXOC3L1Exocyst complex component 3-like protein. (739 aa)
GNAT3Guanine nucleotide-binding protein G(T) subunit alpha-3. (354 aa)
POMCPro-opiomelanocortin. (258 aa)
GIPGastric inhibitory polypeptide. (145 aa)
EXOC3L4Exocyst complex component 3-like protein 4. (733 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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