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VAV1 VAV1 LOC101371369 LOC101371369 PIK3R1 PIK3R1 LOC101386062 LOC101386062 LYN LYN PTPN6 PTPN6 PIK3CB PIK3CB INPPL1 INPPL1 GAB2 GAB2 GRB2 GRB2 UBC UBC INPP5D INPP5D TEC TEC IL2RG IL2RG PIK3CD PIK3CD PIK3CA PIK3CA PRKACA PRKACA CRKL CRKL PIK3R3 PIK3R3 IL2 IL2 RPS27A RPS27A CRK CRK JAK3 JAK3 PIK3R2 PIK3R2 FYN FYN JAK2 JAK2 IL5 IL5 LOC101364817 LOC101364817 CSF2 CSF2 CBL CBL YES1 YES1 IL2RB IL2RB CSF2RB CSF2RB STAT5A STAT5A PTPN11 PTPN11 SYK SYK SOS1 SOS1 SRMS SRMS PTK6 PTK6 LOC101376426 LOC101376426 LOC101372053 LOC101372053 JAK1 JAK1 IL2RA IL2RA STAT5B STAT5B LOC101374328 LOC101374328 UBA52 UBA52 SHC1 SHC1 RAPGEF1 RAPGEF1 YWHAZ YWHAZ IL3RA IL3RA LOC105757391 LOC105757391 CSF2RA CSF2RA IL5RA IL5RA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VAV1Proto-oncogene vav isoform X1. (864 aa)
LOC101371369Polyubiquitin. (153 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
LOC101386062Ubiquitin-like. (109 aa)
LYNTyrosine-protein kinase. (512 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
INPPL1Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2. (1264 aa)
GAB2GRB2-associated-binding protein 2. (677 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
UBCpolyubiquitin-C. (229 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1188 aa)
TECTyrosine-protein kinase. (631 aa)
IL2RGCytokine receptor common subunit gamma. (374 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
CRKLCrk-like protein. (303 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
FYNTyrosine-protein kinase. (537 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
LOC101364817Uncharacterized protein LOC101364817. (316 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (153 aa)
CBLE3 ubiquitin-protein ligase CBL. (910 aa)
YES1Tyrosine-protein kinase. (541 aa)
IL2RBInterleukin-2 receptor subunit beta. (550 aa)
CSF2RBCytokine receptor common subunit beta. (902 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
SYKTyrosine-protein kinase. (635 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
SRMSTyrosine-protein kinase. (493 aa)
PTK6Tyrosine-protein kinase. (451 aa)
LOC101376426Ubiquitin-like. (101 aa)
LOC101372053Tyrosine-protein kinase. (620 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
IL2RAInterleukin-2 receptor subunit alpha. (422 aa)
STAT5BSignal transducer and activator of transcription. (818 aa)
LOC101374328Tyrosine-protein phosphatase non-receptor type 11-like. (581 aa)
UBA52ubiquitin-60S ribosomal protein L40 isoform X1. (183 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1270 aa)
YWHAZ14-3-3 protein zeta/delta isoform X1; Belongs to the 14-3-3 family. (256 aa)
IL3RALOW QUALITY PROTEIN: interleukin-3 receptor subunit alpha. (462 aa)
LOC105757391Granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like. (407 aa)
CSF2RAGranulocyte-macrophage colony-stimulating factor receptor subunit alpha. (455 aa)
IL5RAInterleukin-5 receptor subunit alpha. (417 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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