STRINGSTRING
GAB1 GAB1 FRS2 FRS2 HRAS HRAS FGF17 FGF17 FGF8 FGF8 FGF9 FGF9 PIK3CA PIK3CA FLRT2 FLRT2 FGF1 FGF1 ERAS ERAS FGF22 FGF22 FGFR1 FGFR1 GRB2 GRB2 FGF3 FGF3 FLRT1 FLRT1 FGF4 FGF4 PTPN11 PTPN11 FLRT3 FLRT3 LOC101367134 LOC101367134 FGF10 FGF10 FGF6 FGF6 FGF23 FGF23 PIK3R1 PIK3R1 NRAS NRAS CSDE1 CSDE1 FGF2 FGF2 SHC1 SHC1 LOC101374328 LOC101374328 FRS3 FRS3 PLCG1 PLCG1 KRAS KRAS SOS1 SOS1 FGF20 FGF20 FGF5 FGF5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GAB1GRB2-associated-binding protein 1 isoform X1. (724 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
HRASGTPase HRas isoform X1. (189 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FLRT2Leucine-rich repeat transmembrane protein FLRT2. (660 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ERASGTPase ERas. (233 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
FLRT1Leucine-rich repeat transmembrane protein FLRT1. (674 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
FLRT3Leucine-rich repeat transmembrane protein FLRT3. (649 aa)
LOC101367134GTPase HRas-like. (177 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
NRASGTPase NRas. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (852 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (377 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
LOC101374328Tyrosine-protein phosphatase non-receptor type 11-like. (581 aa)
FRS3Fibroblast growth factor receptor substrate 3. (495 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
KRASGTPase KRas isoform X1. (227 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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