STRINGSTRING
GAB1 GAB1 FGF18 FGF18 FGF4 FGF4 GRB2 GRB2 KLB KLB FGF1 FGF1 PIK3CA PIK3CA FGF9 FGF9 FGF8 FGF8 FGF17 FGF17 FRS2 FRS2 FGF20 FGF20 PTPN11 PTPN11 FGF16 FGF16 KL KL FGF6 FGF6 FGF23 FGF23 PIK3R1 PIK3R1 FGFR4 FGFR4 FGF2 FGF2 LOC101374328 LOC101374328 FGF19 FGF19
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GAB1GRB2-associated-binding protein 1 isoform X1. (724 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
KLBBeta-klotho. (1037 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
KLKlotho. (1010 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
FGFR4Fibroblast growth factor receptor. (856 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (377 aa)
LOC101374328Tyrosine-protein phosphatase non-receptor type 11-like. (581 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.