STRINGSTRING
PPP2CA PPP2CA LOC101376426 LOC101376426 PPP2R1A PPP2R1A PPP2R1B PPP2R1B USP2 USP2 MDM4 MDM4 UBA52 UBA52 MAPKAP1 MAPKAP1 CDK2 CDK2 PPP2R5C PPP2R5C RFFL RFFL LOC101371369 LOC101371369 ARHGAP8 ARHGAP8 PRR5 PRR5 LOC101386062 LOC101386062 MTOR MTOR PPP2CB PPP2CB DAXX DAXX CDK1 CDK1 MDM2 MDM2 KXD1 KXD1 RICTOR RICTOR RPS27A RPS27A PDPK1 PDPK1 MLST8 MLST8 CCNA2 CCNA2 USP7 USP7 TXNDC11 TXNDC11 SGK1 SGK1 ATM ATM AKT3 AKT3 CCNA1 CCNA1 TP53 TP53 PRDM1 PRDM1 AKT2 AKT2 UBC UBC RNF34 RNF34 AKT1 AKT1 CDK3 CDK3 PHF20 PHF20 CCNG1 CCNG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP2CASerine/threonine-protein phosphatase. (309 aa)
LOC101376426Ubiquitin-like. (101 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1. (590 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1. (694 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (668 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (492 aa)
UBA52ubiquitin-60S ribosomal protein L40 isoform X1. (183 aa)
MAPKAP1Target of rapamycin complex 2 subunit MAPKAP1 isoform X1. (522 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (558 aa)
RFFLE3 ubiquitin-protein ligase rififylin isoform X1. (363 aa)
LOC101371369Polyubiquitin. (153 aa)
ARHGAP8LOW QUALITY PROTEIN: rho GTPase-activating protein 8. (490 aa)
PRR5Proline-rich protein 5. (389 aa)
LOC101386062Ubiquitin-like. (109 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2559 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
DAXXDeath domain-associated protein 6 isoform X1. (757 aa)
CDK1Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily. (297 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
KXD1kxDL motif-containing protein 1 isoform X1. (262 aa)
RICTORRapamycin-insensitive companion of mTOR isoform X1. (1732 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
MLST8Target of rapamycin complex subunit LST8. (326 aa)
CCNA2cyclin-A2 isoform X1; Belongs to the cyclin family. (433 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7 isoform X2; Belongs to the peptidase C19 family. (1107 aa)
TXNDC11Thioredoxin domain-containing protein 11. (960 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CCNA1cyclin-A1; Belongs to the cyclin family. (421 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
PRDM1PR domain zinc finger protein 1 isoform X3. (818 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
UBCpolyubiquitin-C. (229 aa)
RNF34E3 ubiquitin-protein ligase RNF34 isoform X1. (375 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CDK3Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
PHF20PHD finger protein 20. (1013 aa)
CCNG1cyclin-G1; Belongs to the cyclin family. (295 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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