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| | WRAP53 | Telomerase Cajal body protein 1. (532 aa) |
| | LOC101373735 | Late histone H2B.L4-like; Belongs to the histone H2B family. (183 aa) |
| | LOC101370818 | Histone H2B type F-M-like; Belongs to the histone H2B family. (259 aa) |
| | LOC101369930 | LOW QUALITY PROTEIN: histone H2B.3-like; Belongs to the histone H2B family. (93 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | CHTF18 | Chromosome transmission fidelity protein 18 homolog isoform X1. (1011 aa) |
| | OBFC1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (396 aa) |
| | CDK2 | Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa) |
| | HJURP | LOW QUALITY PROTEIN: Holliday junction recognition protein. (818 aa) |
| | RFC1 | Replication factor C subunit 1. (1154 aa) |
| | RPA2 | Replication protein A 32 kDa subunit isoform X1. (278 aa) |
| | LOC105757102 | Replication factor C subunit 5-like. (84 aa) |
| | LOC101375647 | Histone H2B type W-T-like; Belongs to the histone H2B family. (113 aa) |
| | CENPI | Centromere protein I. (743 aa) |
| | LOC101372477 | Late histone H2B.L1-like; Belongs to the histone H2B family. (232 aa) |
| | LOC101369718 | Serine/threonine-protein phosphatase. (305 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | LOC101371079 | Histone-binding protein RBBP4-like. (425 aa) |
| | LOC101375061 | DNA polymerase alpha catalytic subunit-like. (130 aa) |
| | LOC101375640 | Histone H2A; Belongs to the histone H2A family. (113 aa) |
| | NHP2 | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa) |
| | TRUB1 | Probable tRNA pseudouridine synthase 1. (350 aa) |
| | LOC101375053 | Late histone H2B.L4-like; Belongs to the histone H2B family. (140 aa) |
| | LOC101374474 | Histone H2B-like; Belongs to the histone H2B family. (164 aa) |
| | LOC101372592 | LOW QUALITY PROTEIN: late histone H2B.L3-like; Belongs to the histone H2B family. (190 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (641 aa) |
| | PPP6R2 | LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 6 regulatory subunit 2. (998 aa) |
| | POLD1 | DNA polymerase. (1107 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1305 aa) |
| | RPA4 | Replication protein A 30 kDa subunit. (244 aa) |
| | CENPU | Centromere protein U. (442 aa) |
| | LOC101374838 | Late histone H2B.L4-like; Belongs to the histone H2B family. (157 aa) |
| | RFC4 | Replication factor C subunit 4. (424 aa) |
| | LOC101369784 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (73 aa) |
| | LOC101367710 | Histone H2B; Belongs to the histone H2B family. (141 aa) |
| | LOC101364558 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | LOC105758218 | Late histone H2B.L4-like; Belongs to the histone H2B family. (135 aa) |
| | LOC105758220 | Late histone H2B.L4-like; Belongs to the histone H2B family. (146 aa) |
| | LOC101382005 | Late histone H2B.L4-like; Belongs to the histone H2B family. (154 aa) |
| | LOC105758219 | Histone H2B, sperm-like; Belongs to the histone H2B family. (211 aa) |
| | LOC101366452 | Late histone H2B.L4-like; Belongs to the histone H2B family. (111 aa) |
| | LOC101362303 | LOW QUALITY PROTEIN: histone-binding protein RBBP4-like. (425 aa) |
| | LOC105758316 | Late histone H2B.L4-like; Belongs to the histone H2B family. (126 aa) |
| | LOC101375641 | DNA polymerase alpha catalytic subunit-like. (340 aa) |
| | POLD4 | DNA polymerase delta subunit 4 isoform X1. (191 aa) |
| | POT1 | Protection of telomeres protein 1. (653 aa) |
| | LOC105758430 | Histone H2B-like; Belongs to the histone H2B family. (146 aa) |
| | LOC101370014 | Late histone H2B.L4-like; Belongs to the histone H2B family. (138 aa) |
| | LOC101372564 | DNA polymerase alpha catalytic subunit. (590 aa) |
| | LOC101370304 | Late histone H2B.L4-like; Belongs to the histone H2B family. (138 aa) |
| | LOC101374765 | Late histone H2B.L1-like; Belongs to the histone H2B family. (230 aa) |
| | LOC101366939 | Transcriptional regulator ATRX-like. (259 aa) |
| | LOC101386168 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa) |
| | MIS18BP1 | Mis18-binding protein 1. (1140 aa) |
| | DKC1 | H/ACA ribonucleoprotein complex subunit 4 isoform X1. (517 aa) |
| | CENPQ | Centromere protein Q isoform X1. (268 aa) |
| | POLD2 | DNA polymerase delta subunit 2. (469 aa) |
| | LOC101382592 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC101386837 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ITGB3BP | Centromere protein R. (138 aa) |
| | RBBP7 | Histone-binding protein RBBP7 isoform X1. (469 aa) |
| | TERF2IP | Telomeric repeat-binding factor 2-interacting protein 1. (401 aa) |
| | LOC101379964 | Histone H2A; Belongs to the histone H2A family. (143 aa) |
| | LOC101378601 | Histone H2B type F-M-like; Belongs to the histone H2B family. (226 aa) |
| | DSCC1 | Sister chromatid cohesion protein DCC1. (392 aa) |
| | LOC101379471 | Late histone H2B.L4-like; Belongs to the histone H2B family. (190 aa) |
| | LOC101379179 | Late histone H2B.L4-like; Belongs to the histone H2B family. (118 aa) |
| | LOC101378012 | Histone H2B-like; Belongs to the histone H2B family. (199 aa) |
| | TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1117 aa) |
| | ATRX | Transcriptional regulator ATRX. (2226 aa) |
| | GAR1 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (211 aa) |
| | LOC101386320 | Centromere protein S. (165 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | RBPMS2 | RNA-binding protein with multiple splicing 2. (206 aa) |
| | CENPL | Centromere protein L. (346 aa) |
| | ANKRD28 | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1. (1086 aa) |
| | ANKRD66 | Ankyrin repeat domain-containing protein 66. (197 aa) |
| | WRN | Werner syndrome ATP-dependent helicase. (1405 aa) |
| | DAXX | Death domain-associated protein 6 isoform X1. (757 aa) |
| | SMARCA5 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5. (1052 aa) |
| | LOC101379740 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC101380025 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC101382175 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC101364320 | DNA polymerase alpha catalytic subunit-like. (694 aa) |
| | LOC101368730 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC101367269 | Histone H2B; Belongs to the histone H2B family. (122 aa) |
| | LOC101368156 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC101386510 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | LOC101386806 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | RBBP4 | Histone-binding protein RBBP4. (332 aa) |
| | LOC101371707 | Histone H2B type F-M-like; Belongs to the histone H2B family. (219 aa) |
| | LOC101373166 | Late histone H2B.L4-like; Belongs to the histone H2B family. (137 aa) |
| | LOC101372303 | Late histone H2B.L4-like; Belongs to the histone H2B family. (172 aa) |
| | LOC101370527 | Late histone H2B.L4-like; Belongs to the histone H2B family. (136 aa) |
| | LOC101369635 | Late histone H2B.L4-like; Belongs to the histone H2B family. (167 aa) |
| | LOC101371116 | Late histone H2B.L4-like; Belongs to the histone H2B family. (121 aa) |
| | LOC101371407 | Late histone H2B.L4-like; Belongs to the histone H2B family. (178 aa) |
| | MIS18A | Protein Mis18-alpha. (237 aa) |
| | SHQ1 | Protein SHQ1 homolog. (575 aa) |
| | STRA13 | Centromere protein X. (79 aa) |
| | LOC101381948 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (433 aa) |
| | CENPW | Centromere protein W. (88 aa) |
| | LOC101382912 | Histone H2B subacrosomal variant-like; Belongs to the histone H2B family. (122 aa) |
| | CENPH | Centromere protein H. (247 aa) |
| | MEIOB | Meiosis-specific with OB domain-containing protein isoform X2. (471 aa) |
| | PRIM2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (509 aa) |
| | CENPK | Centromere protein K. (273 aa) |
| | TINF2 | LOW QUALITY PROTEIN: TERF1-interacting nuclear factor 2. (485 aa) |
| | PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa) |
| | CCNA2 | cyclin-A2 isoform X1; Belongs to the cyclin family. (433 aa) |
| | LIG1 | DNA ligase. (915 aa) |
| | RECQL4 | ATP-dependent DNA helicase Q4. (1183 aa) |
| | CASC5 | Protein CASC5. (2352 aa) |
| | OIP5 | Protein Mis18-beta. (229 aa) |
| | SMARCA1 | Probable global transcription activator SNF2L1 isoform X1. (1070 aa) |
| | CCNA1 | cyclin-A1; Belongs to the cyclin family. (421 aa) |
| | RCBTB2 | RCC1 and BTB domain-containing protein 2 isoform X1. (551 aa) |
| | RCBTB1 | RCC1 and BTB domain-containing protein 1. (531 aa) |
| | RFC2 | Replication factor C subunit 2 isoform X1. (368 aa) |
| | LOC105757765 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | CTC1 | CST complex subunit CTC1. (1217 aa) |
| | BLM | Bloom syndrome protein isoform X1. (1428 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | EXD2 | Exonuclease 3'-5' domain-containing protein 2. (623 aa) |
| | CENPM | Centromere protein M isoform X1. (180 aa) |
| | RFC5 | Replication factor C subunit 5. (336 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) |
| | LOC101381236 | H/ACA ribonucleoprotein complex subunit 3. (64 aa) |
| | RPA3 | Replication protein A 14 kDa subunit. (121 aa) |
| | CENPO | Centromere protein O. (296 aa) |
| | CENPA | Histone H3-like centromeric protein A isoform X1. (137 aa) |
| | CDK3 | Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa) |
| | TEN1 | CST complex subunit TEN1. (121 aa) |
| | H3F3B | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | PPP6R3 | Serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1. (879 aa) |
| | POLA2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (595 aa) |
| | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2. (1020 aa) |
| | CENPP | Centromere protein P. (288 aa) |
| | ACD | Adrenocortical dysplasia protein homolog. (453 aa) |
| | ANKRD44 | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B. (993 aa) |
| | TERF2 | Telomeric repeat-binding factor 2 isoform X1. (542 aa) |
| | CENPT | Centromere protein T. (557 aa) |
| | CENPC | LOW QUALITY PROTEIN: centromere protein C. (950 aa) |
| | PPP6C | Serine/threonine-protein phosphatase. (305 aa) |
| | CENPN | Centromere protein N isoform X1. (339 aa) |
| | NPM1 | Nucleophosmin isoform X1. (294 aa) |
| | POLD3 | LOW QUALITY PROTEIN: DNA polymerase delta subunit 3. (470 aa) |
| | RSF1 | Remodeling and spacing factor 1. (1435 aa) |
| | LOC101366045 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | LOC101373737 | Centromere protein P-like. (247 aa) |
