STRINGSTRING
FGF10 FGF10 FGF6 FGF6 FGF23 FGF23 PIK3R1 PIK3R1 ATP6V0A4 ATP6V0A4 ATP6V1G3 ATP6V1G3 FGF7 FGF7 FGFR4 FGFR4 FGF2 FGF2 FGFR2 FGFR2 SHC1 SHC1 LOC101374328 LOC101374328 ATP6V0A1 ATP6V0A1 LOC101370160 LOC101370160 PDE3B PDE3B PIK3R4 PIK3R4 FGF19 FGF19 ATP6V0E1 ATP6V0E1 GAB2 GAB2 FGF18 FGF18 TRIB3 TRIB3 ATP6V0D1 ATP6V0D1 ATP6V0D2 ATP6V0D2 FGF4 FGF4 TCIRG1 TCIRG1 FGF3 FGF3 GRB2 GRB2 FGFR1 FGFR1 FGF22 FGF22 ATP6V0A2 ATP6V0A2 KLB KLB FGFR3 FGFR3 LOC101383455 LOC101383455 ATP6V1G1 ATP6V1G1 MAPK3 MAPK3 ATP6V1D ATP6V1D FGF1 FGF1 ATP6V1F ATP6V1F PIK3CA PIK3CA SPEM1 SPEM1 LOC101369007 LOC101369007 ATP6V1B1 ATP6V1B1 LOC101378833 LOC101378833 NRD1 NRD1 CNST CNST MAPK1 MAPK1 PTPRF PTPRF ATP6V0B ATP6V0B FGF9 FGF9 ATP6V1C2 ATP6V1C2 FGF8 FGF8 FGF17 FGF17 ATP6V1C1 ATP6V1C1 ATP6V0C ATP6V0C PDPK1 PDPK1 ATP6V1E2 ATP6V1E2 CTSD CTSD INS INS THEM4 THEM4 PIK3R2 PIK3R2 ATP6AP1L ATP6AP1L FRS2 FRS2 ATP6V1E1 ATP6V1E1 GAB1 GAB1 FGF5 FGF5 ATP6V0E2 ATP6V0E2 LOC101382467 LOC101382467 FGF20 FGF20 IRS2 IRS2 IRS1 IRS1 FLT3LG FLT3LG SOS1 SOS1 LIM2 LIM2 ATP6V1H ATP6V1H PTPN11 PTPN11 IDE IDE LOC101376257 LOC101376257 INSR INSR PTPN1 PTPN1 LOC101384010 LOC101384010 PIK3CB PIK3CB ATP6V1B2 ATP6V1B2 ATP6AP1 ATP6AP1 FLT3 FLT3 ATP6V1A ATP6V1A GRB10 GRB10 FGF16 FGF16 PIK3C3 PIK3C3 ATP6V1G2 ATP6V1G2 KL KL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (840 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGFR4Fibroblast growth factor receptor. (856 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (377 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
LOC101374328Tyrosine-protein phosphatase non-receptor type 11-like. (581 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (845 aa)
LOC101370160Toll-like receptor 9 isoform X1. (1056 aa)
PDE3BPhosphodiesterase. (1112 aa)
PIK3R4Phosphoinositide 3-kinase regulatory subunit 4. (1358 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
ATP6V0E1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
GAB2GRB2-associated-binding protein 2. (677 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
TRIB3Tribbles homolog 3. (358 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (828 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (854 aa)
KLBBeta-klotho. (1037 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
LOC101383455V-type proton ATPase subunit E 1-like isoform X1. (226 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ATP6V1DV-type proton ATPase subunit D. (247 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SPEM1Spermatid maturation protein 1. (311 aa)
LOC101369007Uncharacterized protein C17orf74 homolog. (480 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
LOC101378833Insulin receptor substrate 2-like. (528 aa)
NRD1Nardilysin isoform X1. (1231 aa)
CNSTConsortin. (715 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PTPRFReceptor-type tyrosine-protein phosphatase F isoform X1. (1906 aa)
ATP6V0BV-type proton ATPase 21 kDa proteolipid subunit isoform X1; Belongs to the V-ATPase proteolipid subunit family. (205 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (427 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
ATP6V1E2V-type proton ATPase subunit E 2. (226 aa)
CTSDCathepsin D isoform X1; Belongs to the peptidase A1 family. (410 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
THEM4Acyl-coenzyme A thioesterase THEM4. (259 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
ATP6AP1LV-type proton ATPase subunit S1-like protein. (343 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
ATP6V1E1V-type proton ATPase subunit E 1 isoform X1. (226 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (724 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
ATP6V0E2V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
LOC101382467V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
IRS2Insulin receptor substrate 2. (1327 aa)
IRS1Insulin receptor substrate 1. (1233 aa)
FLT3LGFms-related tyrosine kinase 3 ligand. (294 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
LIM2Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family. (214 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
IDEInsulin-degrading enzyme isoform X1; Belongs to the peptidase M16 family. (1019 aa)
LOC101376257Uncharacterized protein LOC101376257. (279 aa)
INSRTyrosine-protein kinase receptor. (1381 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (427 aa)
LOC101384010V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa)
ATP6AP1V-type proton ATPase subunit S1. (464 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
ATP6V1AV-type proton ATPase catalytic subunit A. (618 aa)
GRB10Growth factor receptor-bound protein 10. (586 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
KLKlotho. (1010 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.