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PIK3CB PIK3CB PRKACB PRKACB GFRA1 GFRA1 GAB1 GAB1 LOC101385588 LOC101385588 DOK5 DOK5 PLCG1 PLCG1 RET RET SRC SRC LOC101374328 LOC101374328 MAPK7 MAPK7 SHC1 SHC1 PDLIM7 PDLIM7 PDLIM5 PDLIM5 LOC101373617 LOC101373617 NXPE4 NXPE4 PIK3R1 PIK3R1 PRKCA PRKCA GRB10 GRB10 GRB7 GRB7 NRTN NRTN PSPN PSPN DOK4 DOK4 PIK3CD PIK3CD GFRA3 GFRA3 GFRA4 GFRA4 PIK3CA PIK3CA DOK1 DOK1 PRKACA PRKACA FNDC3A FNDC3A PIK3R3 PIK3R3 ARTN ARTN DOK2 DOK2 GFRA2 GFRA2 DOK6 DOK6 GDNF GDNF PIK3R2 PIK3R2 FRS2 FRS2 IRS2 IRS2 SHANK3 SHANK3 IRS1 IRS1 SHC3 SHC3 SOS1 SOS1 PTPN11 PTPN11 LOC101378783 LOC101378783 RAP1GAP RAP1GAP GAB2 GAB2 FNDC3B FNDC3B GRB2 GRB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (358 aa)
GFRA1GDNF family receptor alpha-1 isoform X1. (535 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (724 aa)
LOC101385588LOW QUALITY PROTEIN: NXPE family member 1. (515 aa)
DOK5Docking protein 5. (259 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1103 aa)
SRCTyrosine-protein kinase. (553 aa)
LOC101374328Tyrosine-protein phosphatase non-receptor type 11-like. (581 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (806 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
PDLIM7PDZ and LIM domain protein 7 isoform X1. (461 aa)
PDLIM5PDZ and LIM domain protein 5 isoform X1. (734 aa)
LOC101373617LOW QUALITY PROTEIN: NXPE family member 2. (438 aa)
NXPE4LOW QUALITY PROTEIN: NXPE family member 4. (196 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
GRB10Growth factor receptor-bound protein 10. (586 aa)
GRB7Growth factor receptor-bound protein 7 isoform X1. (530 aa)
NRTNLOW QUALITY PROTEIN: neurturin. (197 aa)
PSPNPersephin. (146 aa)
DOK4Docking protein 4. (326 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GFRA3GDNF family receptor alpha-3. (399 aa)
GFRA4GDNF family receptor alpha-4. (268 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
DOK1Docking protein 1 isoform X1. (483 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1199 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
ARTNLOW QUALITY PROTEIN: artemin. (203 aa)
DOK2Docking protein 2. (411 aa)
GFRA2GDNF family receptor alpha; Belongs to the GDNFR family. (464 aa)
DOK6Docking protein 6. (331 aa)
GDNFGlial cell line-derived neurotrophic factor isoform X1. (211 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
IRS2Insulin receptor substrate 2. (1327 aa)
SHANK3SH3 and multiple ankyrin repeat domains protein 3. (1733 aa)
IRS1Insulin receptor substrate 1. (1233 aa)
SHC3SHC-transforming protein 3. (587 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
LOC101378783Fibronectin type III domain containing protein 3C1-like. (1383 aa)
RAP1GAPRap1 GTPase-activating protein 1 isoform X1. (727 aa)
GAB2GRB2-associated-binding protein 2. (677 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1208 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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