18 items (Odobenus rosmarus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
	LYN	Tyrosine-protein kinase. (512 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
	GRB2	Growth factor receptor-bound protein 2 isoform X1. (217 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5. (875 aa)
	EPOR	Erythropoietin receptor; Receptor for erythropoietin. (509 aa)
	EPO	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
	CRKL	Crk-like protein. (303 aa)
	GAB1	GRB2-associated-binding protein 1 isoform X1. (724 aa)
	JAK2	Tyrosine-protein kinase. (1130 aa)
	IRS2	Insulin receptor substrate 2. (1327 aa)
	IRS1	Insulin receptor substrate 1. (1233 aa)
	PIK3CG	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1121 aa)
	SHC1	SHC-transforming protein 1 isoform X1. (609 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (1270 aa)
	VAV1	Proto-oncogene vav isoform X1. (864 aa)

Your Current Organism:

Odobenus rosmarus

NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRKL	EPO	A0A2U3VYG3	A0A2U3VUM6	Crk-like protein.	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	0.492
CRKL	EPOR	A0A2U3VYG3	A0A2U3VUA7	Crk-like protein.	Erythropoietin receptor; Receptor for erythropoietin.	0.625
CRKL	GAB1	A0A2U3VYG3	A0A2U3WF15	Crk-like protein.	GRB2-associated-binding protein 1 isoform X1.	0.987
CRKL	GRB2	A0A2U3VYG3	A0A2U3VHU3	Crk-like protein.	Growth factor receptor-bound protein 2 isoform X1.	0.806
CRKL	IRS1	A0A2U3VYG3	A0A2U3WLJ5	Crk-like protein.	Insulin receptor substrate 1.	0.450
CRKL	IRS2	A0A2U3VYG3	A0A2U3WL54	Crk-like protein.	Insulin receptor substrate 2.	0.450
CRKL	JAK2	A0A2U3VYG3	A0A2U3WH50	Crk-like protein.	Tyrosine-protein kinase.	0.603
CRKL	LYN	A0A2U3VYG3	A0A2U3WXZ8	Crk-like protein.	Tyrosine-protein kinase.	0.642
CRKL	PIK3CA	A0A2U3VYG3	A0A2U3VSW6	Crk-like protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.764
CRKL	PIK3CB	A0A2U3VYG3	A0A2U3WV15	Crk-like protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family.	0.729
CRKL	PIK3CD	A0A2U3VYG3	A0A2U3VQZ1	Crk-like protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.733
CRKL	PIK3R1	A0A2U3VYG3	A0A2U3X1Z3	Crk-like protein.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.871
CRKL	RAPGEF1	A0A2U3VYG3	A0A2U3ZI88	Crk-like protein.	Rap guanine nucleotide exchange factor 1.	0.998
CRKL	SHC1	A0A2U3VYG3	A0A2U3ZJC4	Crk-like protein.	SHC-transforming protein 1 isoform X1.	0.743
CRKL	VAV1	A0A2U3VYG3	A0A2U3ZAX0	Crk-like protein.	Proto-oncogene vav isoform X1.	0.593
EPO	CRKL	A0A2U3VUM6	A0A2U3VYG3	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Crk-like protein.	0.492
EPO	EPOR	A0A2U3VUM6	A0A2U3VUA7	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Erythropoietin receptor; Receptor for erythropoietin.	0.997
EPO	GRB2	A0A2U3VUM6	A0A2U3VHU3	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Growth factor receptor-bound protein 2 isoform X1.	0.612
EPO	IRS1	A0A2U3VUM6	A0A2U3WLJ5	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Insulin receptor substrate 1.	0.456
EPO	IRS2	A0A2U3VUM6	A0A2U3WL54	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.	Insulin receptor substrate 2.	0.456