24 items (Odobenus rosmarus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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protein homology

Your Input:
	IRS2	Insulin receptor substrate 2. (1327 aa)
	NOS1	Nitric oxide synthase; Produces nitric oxide (NO). (1433 aa)
	IL6	Interleukin-6 isoform X1. (212 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
	FOXO1	Forkhead box protein O1. (662 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1157 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	LOC101382346	Cathepsin L1-like; Belongs to the peptidase C1 family. (333 aa)
	LIPE	Hormone-sensitive lipase. (762 aa)
	G6PC	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
	LOC101364428	Cathepsin L1-like; Belongs to the peptidase C1 family. (325 aa)
	PRKACB	cAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (358 aa)
	CD4	T-cell surface glycoprotein CD4. (462 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha. (468 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	LOC101362126	Cathepsin L1; Belongs to the peptidase C1 family. (334 aa)
	CCL2	C-C motif chemokine. (101 aa)
	IL10	Interleukin-10. (178 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1208 aa)
	LEPR	Leptin receptor isoform X1. (1166 aa)
	LOC101364724	Cathepsin L1-like; Belongs to the peptidase C1 family. (334 aa)
	CD36	Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family. (472 aa)

Your Current Organism:

Odobenus rosmarus

NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL2	CD4	A0A2U3X461	A0A2U3WWZ7	C-C motif chemokine.	T-cell surface glycoprotein CD4.	0.668
CCL2	IFNG	A0A2U3X461	A0A2U3X2V9	C-C motif chemokine.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.799
CCL2	IL10	A0A2U3X461	A0A2U3X5H9	C-C motif chemokine.	Interleukin-10.	0.821
CCL2	IL1B	A0A2U3X461	A0A2U3VWQ9	C-C motif chemokine.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.805
CCL2	IL6	A0A2U3X461	A0A2U3VQB3	C-C motif chemokine.	Interleukin-6 isoform X1.	0.916
CCL2	INS	A0A2U3X461	A0A2U3W6R9	C-C motif chemokine.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.542
CCL2	LEP	A0A2U3X461	A0A2U3VS59	C-C motif chemokine.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.451
CCL2	NOS2	A0A2U3X461	A0A2U3VW76	C-C motif chemokine.	Nitric oxide synthase; Produces nitric oxide (NO).	0.450
CD36	CD4	A0A2U3ZTY4	A0A2U3WWZ7	Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family.	T-cell surface glycoprotein CD4.	0.560
CD36	IFNG	A0A2U3ZTY4	A0A2U3X2V9	Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.437
CD36	IL10	A0A2U3ZTY4	A0A2U3X5H9	Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family.	Interleukin-10.	0.443
CD36	IL1B	A0A2U3ZTY4	A0A2U3VWQ9	Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.466
CD36	IL6	A0A2U3ZTY4	A0A2U3VQB3	Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family.	Interleukin-6 isoform X1.	0.486
CD36	INS	A0A2U3ZTY4	A0A2U3W6R9	Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.529
CD36	LEP	A0A2U3ZTY4	A0A2U3VS59	Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.442
CD36	LEPR	A0A2U3ZTY4	A0A2U3ZS94	Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family.	Leptin receptor isoform X1.	0.466
CD36	LIPE	A0A2U3ZTY4	A0A2U3WHM0	Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family.	Hormone-sensitive lipase.	0.517
CD36	PPARA	A0A2U3ZTY4	A0A2U3X1E5	Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family.	Peroxisome proliferator-activated receptor alpha.	0.594
CD4	CCL2	A0A2U3WWZ7	A0A2U3X461	T-cell surface glycoprotein CD4.	C-C motif chemokine.	0.668
CD4	CD36	A0A2U3WWZ7	A0A2U3ZTY4	T-cell surface glycoprotein CD4.	Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family.	0.560