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| | AK6 | Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (172 aa) |
| | NUDT9 | ADP-ribose pyrophosphatase, mitochondrial isoform X1. (350 aa) |
| | RRM1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa) |
| | PDE2A | Phosphodiesterase. (943 aa) |
| | APRT | Adenine phosphoribosyltransferase. (180 aa) |
| | LOC101373190 | 5-hydroxyisourate hydrolase; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (139 aa) |
| | NPR2 | Guanylate cyclase. (1047 aa) |
| | PDE1A | Phosphodiesterase. (531 aa) |
| | AK1 | Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (210 aa) |
| | AK8 | Adenylate kinase 8; Belongs to the adenylate kinase family. (479 aa) |
| | DCK | Deoxycytidine kinase isoform X1. (260 aa) |
| | NT5C | 5'(3')-deoxyribonucleotidase, cytosolic type. (211 aa) |
| | GUCY1A3 | Guanylate cyclase soluble subunit alpha-3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa) |
| | AMPD3 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (777 aa) |
| | ADCY3 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa) |
| | LOC101381906 | Nucleoside diphosphate kinase. (152 aa) |
| | LOC105757063 | Nucleoside diphosphate kinase. (152 aa) |
| | ADSSL1 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (459 aa) |
| | PDE6D | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...] (150 aa) |
| | PDE6B | Phosphodiesterase. (856 aa) |
| | ADSL | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (491 aa) |
| | ITPA | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (361 aa) |
| | PDE8A | Phosphodiesterase. (835 aa) |
| | HDDC3 | guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase MESH1. (179 aa) |
| | ENTPD6 | LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family. (472 aa) |
| | PFAS | Phosphoribosylformylglycinamidine synthase. (1338 aa) |
| | DGUOK | Deoxyguanosine kinase, mitochondrial isoform X1. (291 aa) |
| | NME6 | Nucleoside diphosphate kinase. (186 aa) |
| | IMPDH2 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa) |
| | GUCY2F | Guanylate cyclase. (1108 aa) |
| | ADSS | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa) |
| | HPRT1 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (176 aa) |
| | ENPP1 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (925 aa) |
| | ENPP3 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3. (873 aa) |
| | ATIC | Bifunctional purine biosynthesis protein PURH isoform X1. (594 aa) |
| | AMPD1 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (747 aa) |
| | PDE10A | Phosphodiesterase. (794 aa) |
| | PDE5A | Phosphodiesterase. (865 aa) |
| | RRM2 | Ribonucleoside-diphosphate reductase subunit M2 isoform X1. (392 aa) |
| | GMPR2 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (429 aa) |
| | ENTPD4 | Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (616 aa) |
| | PDE7A | Phosphodiesterase. (483 aa) |
| | RRM2B | Ribonucleoside-diphosphate reductase subunit M2 B isoform X1. (351 aa) |
| | LOC101381565 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (227 aa) |
| | NT5C1A | Cytosolic 5'-nucleotidase 1A. (365 aa) |
| | PDE6A | Phosphodiesterase. (861 aa) |
| | PKLR | Pyruvate kinase; Belongs to the pyruvate kinase family. (573 aa) |
| | NPR1 | Guanylate cyclase. (1080 aa) |
| | NME4 | Nucleoside diphosphate kinase. (187 aa) |
| | NME3 | Nucleoside diphosphate kinase. (169 aa) |
| | ADCY9 | Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa) |
| | PDE11A | Phosphodiesterase. (934 aa) |
| | PRUNE | Protein prune homolog isoform X1. (453 aa) |
| | PDE6G | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma. (87 aa) |
| | PDE4C | Phosphodiesterase. (694 aa) |
| | ALLC | Probable allantoicase. (412 aa) |
| | NT5M | 5'(3')-deoxyribonucleotidase, mitochondrial. (187 aa) |
| | LOC101374608 | Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (172 aa) |
| | GMPR | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (345 aa) |
| | PDE1B | Phosphodiesterase. (496 aa) |
| | GART | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1010 aa) |
| | AK2 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (241 aa) |
| | PDE9A | Phosphodiesterase. (532 aa) |
| | CECR1 | Adenosine deaminase CECR1. (521 aa) |
| | PDE6H | Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma. (83 aa) |
| | GUCY2C | Guanylate cyclase. (1071 aa) |
| | ADK | Adenosine kinase. (305 aa) |
| | GUK1 | Guanylate kinase. (219 aa) |
| | AMPD2 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (916 aa) |
| | NT5E | 5'-nucleotidase isoform X1; Belongs to the 5'-nucleotidase family. (574 aa) |
| | ENPP4 | Bis(5'-adenosyl)-triphosphatase ENPP4. (453 aa) |
| | NTPCR | Cancer-related nucleoside-triphosphatase. (190 aa) |
| | PDE4D | Phosphodiesterase. (811 aa) |
| | NUDT5 | ADP-sugar pyrophosphatase; Belongs to the Nudix hydrolase family. (219 aa) |
| | PRPS2 | Ribose-phosphate pyrophosphokinase 2 isoform X1. (325 aa) |
| | XDH | Xanthine dehydrogenase/oxidase. (1333 aa) |
| | PAPSS2 | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2. (665 aa) |
| | ADCY8 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa) |
| | PDE7B | cAMP-specific 3',5'-cyclic phosphodiesterase 7B; Belongs to the cyclic nucleotide phosphodiesterase family. (339 aa) |
| | AK5 | Adenylate kinase isoenzyme 5; Belongs to the adenylate kinase family. (561 aa) |
| | NT5C3B | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (300 aa) |
| | PDE8B | Phosphodiesterase. (891 aa) |
| | PDE4B | Phosphodiesterase. (737 aa) |
| | AK4 | Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa) |
| | ENTPD3 | Ectonucleoside triphosphate diphosphohydrolase 3 isoform X1; Belongs to the GDA1/CD39 NTPase family. (529 aa) |
| | PDE6C | Phosphodiesterase. (845 aa) |
| | GMPS | GMP synthase [glutamine-hydrolyzing] isoform X1. (699 aa) |
| | ENTPD2 | Ectonucleoside triphosphate diphosphohydrolase 2; Belongs to the GDA1/CD39 NTPase family. (495 aa) |
| | PGM1 | Phosphoglucomutase-1 isoform X1; Belongs to the phosphohexose mutase family. (580 aa) |
| | LOC101366343 | Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family. (304 aa) |
| | ADPRM | Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase. (342 aa) |
| | ADA | Adenosine deaminase. (363 aa) |
| | GUCY1A2 | Guanylate cyclase soluble subunit alpha-2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (723 aa) |
| | NT5C3A | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (331 aa) |
| | URAD | Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase. (176 aa) |
| | PDE1C | Phosphodiesterase. (769 aa) |
| | PKM | Pyruvate kinase; Belongs to the pyruvate kinase family. (590 aa) |
| | ADCY2 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa) |
| | LOC101386058 | Ribonucleoside-diphosphate reductase subunit M2-like isoform X1. (391 aa) |
| | NUDT16 | U8 snoRNA-decapping enzyme. (195 aa) |
| | PPAT | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (517 aa) |
| | LOC101369893 | Cytosolic 5'-nucleotidase 1B isoform X1. (629 aa) |
| | PAICS | Multifunctional protein ADE2. (425 aa) |
| | NME7 | Nucleoside diphosphate kinase 7; Belongs to the NDK family. (276 aa) |
| | AK3 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (223 aa) |
| | LOC101377149 | Guanylate cyclase. (1096 aa) |
| | GUCY1B3 | Guanylate cyclase soluble subunit beta-1 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (643 aa) |
| | LOC101362994 | LOW QUALITY PROTEIN: adenylate kinase; Belongs to the adenylate kinase family. (370 aa) |
| | PGM2 | Phosphoglucomutase-2. (615 aa) |
| | ADCY5 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa) |
| | LOC101364660 | LOW QUALITY PROTEIN: ADP-ribose pyrophosphatase, mitochondrial-like. (300 aa) |
| | GDA | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (469 aa) |
| | IMPDH1 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (574 aa) |
| | GUCY2D | Guanylate cyclase. (1107 aa) |
| | PDE4A | Phosphodiesterase. (871 aa) |
| | ENTPD5 | Ectonucleoside triphosphate diphosphohydrolase 5; Belongs to the GDA1/CD39 NTPase family. (428 aa) |
| | LOC101365290 | Guanylate cyclase soluble subunit beta-2-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (707 aa) |
| | LOC101374406 | LOW QUALITY PROTEIN: ribose-phosphate pyrophosphokinase 1-like. (311 aa) |
| | NUDT2 | Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]. (147 aa) |
| | ADCY6 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa) |
| | NT5C2 | Cytosolic purine 5'-nucleotidase isoform X1. (567 aa) |
| | ADCY4 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa) |
| | LOC105757534 | Phosphodiesterase. (427 aa) |
| | LOC101368838 | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa) |
| | AK9 | Adenylate kinase 9. (1887 aa) |
| | ADCY10 | Adenylate cyclase type 10 isoform X1. (1623 aa) |
| | ADCY7 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa) |
| | LOC101386612 | LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2-like. (394 aa) |
| | ADCY1 | Adenylate cyclase type 1. (907 aa) |
| | FHIT | Bis(5'-adenosyl)-triphosphatase. (149 aa) |
| | LOC101367891 | Guanylate cyclase. (1010 aa) |
| | PNP | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (275 aa) |
| | PRPS1 | Ribose-phosphate pyrophosphokinase 1 isoform X1. (321 aa) |
| | PDE3B | Phosphodiesterase. (1112 aa) |
| | PDE3A | Phosphodiesterase. (791 aa) |
| | ENTPD8 | Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (580 aa) |
| | ENTPD1 | Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (444 aa) |
| | LOC101363792 | Adenylate cyclase type 10-like. (1182 aa) |
| | AK7 | Adenylate kinase 7. (739 aa) |
