STRINGSTRING
MAPK10 MAPK10 CBLB CBLB PAK1 PAK1 PAK2 PAK2 PLCG2 PLCG2 ABL1 ABL1 BTC BTC AREG AREG BAD BAD GRB2 GRB2 EIF4EBP1 EIF4EBP1 ERBB2 ERBB2 MAP2K2 MAP2K2 SHC2 SHC2 AKT1 AKT1 AKT2 AKT2 PAK4 PAK4 SHC4 SHC4 ARAF ARAF ELK1 ELK1 MAPK3 MAPK3 PIK3CD PIK3CD RPS6KB1 RPS6KB1 HBEGF HBEGF NRG2 NRG2 ABL2 ABL2 PIK3CA PIK3CA TGFA TGFA PRKCB PRKCB PAK3 PAK3 PAK6 PAK6 AKT3 AKT3 MAPK1 MAPK1 CRKL CRKL PIK3R3 PIK3R3 ERBB3 ERBB3 CAMK2A CAMK2A GSK3B GSK3B HRAS HRAS CRK CRK PIK3R2 PIK3R2 PTK2 PTK2 CAMK2D CAMK2D GAB1 GAB1 SOS2 SOS2 PRKCG PRKCG NRG3 NRG3 SHC3 SHC3 SOS1 SOS1 STAT5A STAT5A CDKN1B CDKN1B MTOR MTOR NRG1 NRG1 MAP2K7 MAP2K7 NCK2 NCK2 CBL CBL MAPK9 MAPK9 PIK3CB PIK3CB CAMK2B CAMK2B MAP2K1 MAP2K1 PAK7 PAK7 JUN JUN LOC101367134 LOC101367134 PRKCA PRKCA PIK3R1 PIK3R1 RAF1 RAF1 LOC101371484 LOC101371484 NRAS NRAS SHC1 SHC1 EREG EREG SRC SRC MAPK8 MAPK8 CDKN1A CDKN1A MYC MYC EGF EGF STAT5B STAT5B PLCG1 PLCG1 BRAF BRAF NRG4 NRG4 NCK1 NCK1 MAP2K4 MAP2K4 EGFR EGFR RPS6KB2 RPS6KB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK10Mitogen-activated protein kinase. (464 aa)
CBLBE3 ubiquitin-protein ligase CBL-B. (982 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
PAK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (491 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
BTCProbetacellulin. (178 aa)
AREGAmphiregulin isoform X1. (253 aa)
BADBcl2-associated agonist of cell death. (168 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
ERBB2Receptor protein-tyrosine kinase. (1281 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
SHC2SHC-transforming protein 2. (586 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PAK4Non-specific serine/threonine protein kinase. (595 aa)
SHC4SHC-transforming protein 4. (630 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
ELK1ETS domain-containing protein Elk-1. (435 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform isoform X1. (847 aa)
ABL2Tyrosine-protein kinase. (1182 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TGFAProtransforming growth factor alpha isoform X1. (160 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PAK3Serine/threonine-protein kinase PAK 3 isoform X1. (580 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CRKLCrk-like protein. (303 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1339 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
HRASGTPase HRas isoform X1. (189 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
PTK2Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1052 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta. (477 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (724 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1333 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform isoform X1. (722 aa)
SHC3SHC-transforming protein 3. (587 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2559 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform isoform X1. (855 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (435 aa)
NCK2Cytoplasmic protein. (380 aa)
CBLE3 ubiquitin-protein ligase CBL. (910 aa)
MAPK9Mitogen-activated protein kinase. (427 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta isoform X1. (542 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
PAK7Serine/threonine-protein kinase PAK 7. (535 aa)
JUNTranscription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
LOC101367134GTPase HRas-like. (177 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
LOC101371484Receptor tyrosine-protein kinase erbB-4. (838 aa)
NRASGTPase NRas. (189 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
EREGProepiregulin isoform X1. (166 aa)
SRCTyrosine-protein kinase. (553 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1210 aa)
STAT5BSignal transducer and activator of transcription. (818 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
BRAFSerine/threonine-protein kinase B-raf. (772 aa)
NRG4Pro-neuregulin-4, membrane-bound isoform. (131 aa)
NCK1Cytoplasmic protein. (377 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X1; Belongs to the protein kinase superfamily. (411 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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