STRINGSTRING
PDHA2 PDHA2 EIF4E EIF4E PLCG2 PLCG2 VHL VHL ANGPT4 ANGPT4 HKDC1 HKDC1 RELA RELA EIF4EBP1 EIF4EBP1 ERBB2 ERBB2 MAP2K2 MAP2K2 MKNK2 MKNK2 AKT1 AKT1 PFKM PFKM EIF4E2 EIF4E2 AKT2 AKT2 TIMP1 TIMP1 LOC101363102 LOC101363102 MAPK3 MAPK3 IL6 IL6 EP300 EP300 RBX1 RBX1 ENO1 ENO1 PIK3CD PIK3CD RPS6KB1 RPS6KB1 BCL2 BCL2 PIK3CA PIK3CA ENO3 ENO3 HK2 HK2 PRKCB PRKCB EPO EPO SERPINE1 SERPINE1 ALDOC ALDOC NOS2 NOS2 LOC101379802 LOC101379802 EGLN3 EGLN3 LOC101364991 LOC101364991 AKT3 AKT3 MAPK1 MAPK1 MKNK1 MKNK1 PIK3R3 PIK3R3 HK3 HK3 PDHA1 PDHA1 EIF4E1B EIF4E1B NFKB1 NFKB1 LOC101366299 LOC101366299 CAMK2A CAMK2A TCEB2 TCEB2 CREBBP CREBBP LOC101380793 LOC101380793 INS INS ANGPT1 ANGPT1 TCEB1 TCEB1 PIK3R2 PIK3R2 EGLN1 EGLN1 LDHB LDHB RPS6 RPS6 ANGPT2 ANGPT2 SLC2A1 SLC2A1 CAMK2D CAMK2D LOC101367475 LOC101367475 PDK1 PDK1 PFKP PFKP PRKCG PRKCG LOC101373853 LOC101373853 IFNGR1 IFNGR1 STAT3 STAT3 PFKL PFKL CDKN1B CDKN1B MTOR MTOR NPPA NPPA PGK1 PGK1 PFKFB3 PFKFB3 HIF1A HIF1A INSR INSR PDHB PDHB LOC101364543 LOC101364543 IGF1 IGF1 PIK3CB PIK3CB LOC101376002 LOC101376002 ENO4 ENO4 LTBR LTBR ENO2 ENO2 GAPDH GAPDH CAMK2B CAMK2B PGK2 PGK2 ALDOB ALDOB MAP2K1 MAP2K1 FLT1 FLT1 CUL2 CUL2 LOC101363101 LOC101363101 LDHC LDHC LDHAL6A LDHAL6A LOC101375731 LOC101375731 PRKCA PRKCA PIK3R1 PIK3R1 TLR4 TLR4 HMOX1 HMOX1 IFNG IFNG TEK TEK TFRC TFRC LOC101372056 LOC101372056 ALDOA ALDOA EGLN2 EGLN2 LOC101382994 LOC101382994 LOC101375376 LOC101375376 EDN1 EDN1 IL6R IL6R ARNT ARNT LOC101379527 LOC101379527 LOC101372299 LOC101372299 LOC101385013 LOC101385013 LOC101376828 LOC101376828 IGF1R IGF1R VEGFA VEGFA NOS3 NOS3 CDKN1A CDKN1A EGF EGF PLCG1 PLCG1 LOC101380342 LOC101380342 LOC101380043 LOC101380043 HK1 HK1 LOC101366853 LOC101366853 EGFR EGFR RPS6KB2 RPS6KB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (391 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
VHLVon Hippel-Lindau disease tumor suppressor isoform X1. (219 aa)
ANGPT4Angiopoietin-4. (498 aa)
HKDC1Putative hexokinase HKDC1. (917 aa)
RELATranscription factor p65. (539 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
ERBB2Receptor protein-tyrosine kinase. (1281 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
MKNK2MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. (484 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (859 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2 isoform X1; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TIMP1Metalloproteinase inhibitor 1. (257 aa)
LOC101363102Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
IL6Interleukin-6 isoform X1. (212 aa)
EP300Histone acetyltransferase p300. (2421 aa)
RBX1E3 ubiquitin-protein ligase RBX1 isoform X1. (116 aa)
ENO1Alpha-enolase isoform X1. (434 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
BCL2Apoptosis regulator Bcl-2. (235 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENO3Beta-enolase isoform X1. (472 aa)
HK2Hexokinase-2. (917 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1157 aa)
LOC101379802Cytochrome b-245 heavy chain. (570 aa)
EGLN3Egl nine homolog 3 isoform X1. (239 aa)
LOC101364991L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
MKNK1MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1; Belongs to the protein kinase superfamily. (421 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
HK3Hexokinase-3. (924 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
EIF4E1BEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (247 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
LOC101366299Glyceraldehyde-3-phosphate dehydrogenase-like; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
TCEB2Transcription elongation factor B polypeptide 2. (118 aa)
CREBBPCREB-binding protein isoform X1. (2433 aa)
LOC101380793Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ANGPT1Angiopoietin-1 isoform X1. (498 aa)
TCEB1Transcription elongation factor B polypeptide 1; Belongs to the SKP1 family. (112 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
EGLN1Egl nine homolog 1. (428 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
ANGPT2Angiopoietin-2 isoform X1. (495 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta. (477 aa)
LOC101367475L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (340 aa)
PDK1Protein-serine/threonine kinase. (436 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (790 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
LOC101373853L-lactate dehydrogenase A chain-like isoform X1; Belongs to the LDH/MDH superfamily. (346 aa)
IFNGR1Interferon gamma receptor 1. (466 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2559 aa)
NPPANatriuretic peptides A. (152 aa)
PGK1Phosphoglycerate kinase. (417 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform X1. (526 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (822 aa)
INSRTyrosine-protein kinase receptor. (1381 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
LOC101364543L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
IGF1Insulin-like growth factor I isoform X1. (187 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
LOC101376002L-lactate dehydrogenase A chain-like isoform X1; Belongs to the LDH/MDH superfamily. (332 aa)
ENO4Enolase-like protein ENO4. (623 aa)
LTBRTumor necrosis factor receptor superfamily member 3 isoform X1. (425 aa)
ENO2Gamma-enolase isoform X1. (434 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta isoform X1. (542 aa)
PGK2Phosphoglycerate kinase. (417 aa)
ALDOBFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
FLT1Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1338 aa)
CUL2Cullin-2; Belongs to the cullin family. (745 aa)
LOC101363101L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
LDHCL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
LDHAL6ALOW QUALITY PROTEIN: L-lactate dehydrogenase A-like 6A; Belongs to the LDH/MDH superfamily. (330 aa)
LOC101375731L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (362 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
HMOX1Heme oxygenase 1. (322 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
TEKAngiopoietin-1 receptor isoform X1. (1125 aa)
TFRCTransferrin receptor protein 1. (770 aa)
LOC101372056Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (441 aa)
EGLN2Egl nine homolog 2. (405 aa)
LOC101382994Glyceraldehyde-3-phosphate dehydrogenase-like; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
LOC101375376L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
EDN1Endothelin-1 isoform X1. (227 aa)
IL6RInterleukin-6 receptor subunit alpha. (479 aa)
ARNTAryl hydrocarbon receptor nuclear translocator isoform X1. (786 aa)
LOC101379527LOW QUALITY PROTEIN: cullin-2-like; Belongs to the cullin family. (738 aa)
LOC101372299L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
LOC101385013Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
LOC101376828L-lactate dehydrogenase A chain-like isoform X1; Belongs to the LDH/MDH superfamily. (311 aa)
IGF1RTyrosine-protein kinase receptor. (1304 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (587 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1208 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1210 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
LOC101380342Serotransferrin isoform X1; Belongs to the transferrin family. (721 aa)
LOC101380043Inhibitor of carbonic anhydrase-like; Belongs to the transferrin family. (699 aa)
HK1Hexokinase-1 isoform X1. (935 aa)
LOC101366853Glyceraldehyde-3-phosphate dehydrogenase-like; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (327 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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