STRINGSTRING
MAPK10 MAPK10 TNFSF10 TNFSF10 PLK4 PLK4 CCND1 CCND1 SIRT1 SIRT1 LOC101367802 LOC101367802 GRB2 GRB2 MAP2K2 MAP2K2 S1PR4 S1PR4 GADD45B GADD45B STK11 STK11 AKT1 AKT1 AKT2 AKT2 TGFB1 TGFB1 FOXO4 FOXO4 PRKAB1 PRKAB1 ARAF ARAF G6PC2 G6PC2 MAPK3 MAPK3 IL6 IL6 EP300 EP300 PIK3CD PIK3CD HOMER2 HOMER2 PIK3CA PIK3CA GABARAP GABARAP SLC2A4 SLC2A4 PLK1 PLK1 CDKN2D CDKN2D LOC101378833 LOC101378833 TGFB3 TGFB3 FOXO1 FOXO1 NLK NLK IRS4 IRS4 FOXG1 FOXG1 AKT3 AKT3 MAPK1 MAPK1 PIK3R3 PIK3R3 PLK3 PLK3 PRKAG1 PRKAG1 ATM ATM SGK1 SGK1 SOD2 SOD2 USP7 USP7 S1PR1 S1PR1 AGAP2 AGAP2 CHUK CHUK BNIP3 BNIP3 LOC101363423 LOC101363423 ATG12 ATG12 PRKAG3 PRKAG3 CREBBP CREBBP PDPK1 PDPK1 CCNB1 CCNB1 HRAS HRAS INS INS IL7R IL7R SKP2 SKP2 KLF2 KLF2 PIK3R2 PIK3R2 HOMER3 HOMER3 HOMER1 HOMER1 SETD7 SETD7 MDM2 MDM2 CAT CAT CCNG2 CCNG2 LOC101376741 LOC101376741 CCNB2 CCNB2 LOC101382057 LOC101382057 SOS2 SOS2 PLK2 PLK2 PRKAG2 PRKAG2 PRKAA1 PRKAA1 RAG2 RAG2 RAG1 RAG1 IRS2 IRS2 MAPK11 MAPK11 MAPK12 MAPK12 PTEN PTEN IRS1 IRS1 MAPK13 MAPK13 MAPK14 MAPK14 GADD45G GADD45G PRMT1 PRMT1 SOS1 SOS1 FBXO32 FBXO32 SMAD4 SMAD4 STAT3 STAT3 G6PC G6PC LOC101376946 LOC101376946 CDKN1B CDKN1B INSR INSR FASLG FASLG GABARAPL1 GABARAPL1 MAPK9 MAPK9 IGF1 IGF1 PIK3CB PIK3CB BCL6 BCL6 STK4 STK4 MAP2K1 MAP2K1 SMAD3 SMAD3 PRKAA2 PRKAA2 GADD45A GADD45A LOC101367134 LOC101367134 TGFB2 TGFB2 IKBKB IKBKB CCND2 CCND2 PIK3R1 PIK3R1 FBXO25 FBXO25 TGFBR2 TGFBR2 PRKAB2 PRKAB2 SGK2 SGK2 IL10 IL10 LOC101366345 LOC101366345 RAF1 RAF1 RBL2 RBL2 CCNB3 CCNB3 TGFBR1 TGFBR1 NRAS NRAS PCK2 PCK2 IGF1R IGF1R G6PC3 G6PC3 FOXO6 FOXO6 MAPK8 MAPK8 CDKN1A CDKN1A EGF EGF GABARAPL2 GABARAPL2 BRAF BRAF EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK10Mitogen-activated protein kinase. (464 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (286 aa)
PLK4Serine/threonine-protein kinase PLK4 isoform X1. (970 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (740 aa)
LOC101367802Forkhead box protein J3-like. (247 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
S1PR4Sphingosine 1-phosphate receptor 4 isoform X1. (385 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (161 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (439 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TGFB1Transforming growth factor beta-1. (287 aa)
FOXO4Forkhead box protein O4. (509 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
IL6Interleukin-6 isoform X1. (212 aa)
EP300Histone acetyltransferase p300. (2421 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
HOMER2Homer protein homolog 2 isoform X1. (343 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GABARAPGamma-aminobutyric acid receptor-associated protein. (117 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (508 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
CDKN2DCyclin-dependent kinase 4 inhibitor D. (166 aa)
LOC101378833Insulin receptor substrate 2-like. (528 aa)
TGFB3Transforming growth factor beta-3. (461 aa)
FOXO1Forkhead box protein O1. (662 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
IRS4LOW QUALITY PROTEIN: insulin receptor substrate 4. (1307 aa)
FOXG1Forkhead box protein G1. (489 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
PLK3Serine/threonine-protein kinase PLK. (698 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X1. (337 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7 isoform X2; Belongs to the peptidase C19 family. (1107 aa)
S1PR1Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
AGAP2arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1. (1189 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
BNIP3BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (194 aa)
LOC101363423Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (490 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (464 aa)
CREBBPCREB-binding protein isoform X1. (2433 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
CCNB1G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (427 aa)
HRASGTPase HRas isoform X1. (189 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
IL7RInterleukin-7 receptor subunit alpha. (458 aa)
SKP2S-phase kinase-associated protein 2 isoform X1. (436 aa)
KLF2Krueppel-like factor 2. (357 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
HOMER3Homer protein homolog 3 isoform X1. (359 aa)
HOMER1Homer protein homolog 1 isoform X1. (354 aa)
SETD7Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. (366 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (541 aa)
CCNG2cyclin-G2; Belongs to the cyclin family. (343 aa)
LOC101376741Forkhead box protein O3. (453 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (358 aa)
LOC101382057Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (183 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1333 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2 isoform X1. (569 aa)
PRKAA1Non-specific serine/threonine protein kinase. (528 aa)
RAG2V(D)J recombination-activating protein 2. (527 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
IRS2Insulin receptor substrate 2. (1327 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
IRS1Insulin receptor substrate 1. (1233 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
PRMT1Protein arginine N-methyltransferase 1 isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
FBXO32F-box only protein 32 isoform X1. (355 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
LOC101376946Casein kinase I isoform epsilon isoform X1; Belongs to the protein kinase superfamily. (416 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
INSRTyrosine-protein kinase receptor. (1381 aa)
FASLGTumor necrosis factor ligand superfamily member 6 isoform X1; Belongs to the tumor necrosis factor family. (277 aa)
GABARAPL1Gamma-aminobutyric acid receptor-associated protein-like 1. (117 aa)
MAPK9Mitogen-activated protein kinase. (427 aa)
IGF1Insulin-like growth factor I isoform X1. (187 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
STK4Serine/threonine-protein kinase 4 isoform X1. (487 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
LOC101367134GTPase HRas-like. (177 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
FBXO25F-box only protein 25 isoform X1. (367 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2 isoform X1. (272 aa)
SGK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (367 aa)
IL10Interleukin-10. (178 aa)
LOC101366345LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B2-like; Belongs to the cyclin family. (397 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
RBL2Retinoblastoma-like protein 2 isoform X1. (1139 aa)
CCNB3G2/mitotic-specific cyclin-B3; Belongs to the cyclin family. (1336 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
NRASGTPase NRas. (189 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1. (668 aa)
IGF1RTyrosine-protein kinase receptor. (1304 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
FOXO6Forkhead box protein O6. (491 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1210 aa)
GABARAPL2Gamma-aminobutyric acid receptor-associated protein-like 2. (117 aa)
BRAFSerine/threonine-protein kinase B-raf. (772 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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