STRINGSTRING
MAPK10 MAPK10 ATG3 ATG3 UVRAG UVRAG KIAA0226 KIAA0226 STX17 STX17 MTMR14 MTMR14 RAB7B RAB7B BCL2L1 BCL2L1 TP53INP2 TP53INP2 CFLAR CFLAR ATG2A ATG2A WIPI2 WIPI2 BAD BAD PRAP1 PRAP1 CTSB CTSB MAP2K2 MAP2K2 DAPK3 DAPK3 STK11 STK11 RAB7A RAB7A AKT1 AKT1 CAMKK2 CAMKK2 ATG16L1 ATG16L1 AKT2 AKT2 IGBP1 IGBP1 MAPK3 MAPK3 PIK3CD PIK3CD EIF2S1 EIF2S1 RAB1A RAB1A VMP1 VMP1 RPS6KB1 RPS6KB1 ATG5 ATG5 BCL2 BCL2 PRKCQ PRKCQ PIK3CA PIK3CA GABARAP GABARAP ATG4D ATG4D PRKACA PRKACA LOC101378833 LOC101378833 ZFYVE1 ZFYVE1 ATG13 ATG13 IRS4 IRS4 EIF2AK4 EIF2AK4 AKT3 AKT3 SNAP29 SNAP29 MAPK1 MAPK1 PIK3R3 PIK3R3 ATG101 ATG101 BNIP3 BNIP3 ATG12 ATG12 RB1CC1 RB1CC1 RRAGC RRAGC ATG9A ATG9A TSC2 TSC2 MLST8 MLST8 PDPK1 PDPK1 HRAS HRAS CTSD CTSD INS INS MAP3K7 MAP3K7 RRAGD RRAGD RPTOR RPTOR RAB8A RAB8A PIK3R2 PIK3R2 ATG14 ATG14 ULK2 ULK2 SMCR8 SMCR8 PPP2CA PPP2CA ATG10 ATG10 RRAGA RRAGA WIPI1 WIPI1 ERN1 ERN1 RAB33B RAB33B HMGB1 HMGB1 LAMP2 LAMP2 LOC101382346 LOC101382346 PPP2CB PPP2CB ATG9B ATG9B RHEB RHEB PRKAA1 PRKAA1 TRAF6 TRAF6 DAPK2 DAPK2 IRS2 IRS2 PTEN PTEN IRS1 IRS1 RRAS RRAS AKT1S1 AKT1S1 BECN1 BECN1 LOC101364428 LOC101364428 MTOR MTOR WDR41 WDR41 ATG4C ATG4C HIF1A HIF1A DEPTOR DEPTOR RRAGB RRAGB LAMP1 LAMP1 GABARAPL1 GABARAPL1 MAPK9 MAPK9 SQSTM1 SQSTM1 ATG4B ATG4B DDIT4 DDIT4 MRAS MRAS PIK3CB PIK3CB PRKACB PRKACB EIF2AK3 EIF2AK3 ATG4A ATG4A MAP2K1 MAP2K1 PRKAA2 PRKAA2 PIK3C3 PIK3C3 LOC101367134 LOC101367134 VAMP8 VAMP8 RRAS2 RRAS2 PIK3R1 PIK3R1 NRBF2 NRBF2 LOC101362126 LOC101362126 ATG2B ATG2B LOC101368415 LOC101368415 RAB39B RAB39B ULK1 ULK1 ATG7 ATG7 ATG16L2 ATG16L2 RAF1 RAF1 MTMR4 MTMR4 ITPR1 ITPR1 MTMR3 MTMR3 NRAS NRAS TSC1 TSC1 IGF1R IGF1R MAPK8 MAPK8 SH3GLB1 SH3GLB1 TANK TANK DAPK1 DAPK1 LOC101364724 LOC101364724 PRKCD PRKCD GABARAPL2 GABARAPL2 TBK1 TBK1 BECN2 BECN2 PIK3R4 PIK3R4 RPS6KB2 RPS6KB2 LOC101363616 LOC101363616
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK10Mitogen-activated protein kinase. (464 aa)
ATG3Autophagy-related protein 3. (314 aa)
UVRAGUV radiation resistance-associated gene protein. (699 aa)
KIAA0226Run domain Beclin-1 interacting and cysteine-rich containing protein isoform X1. (972 aa)
STX17Syntaxin-17; Belongs to the syntaxin family. (302 aa)
MTMR14Myotubularin-related protein 14 isoform X1. (648 aa)
RAB7BRas-related protein Rab-7b. (200 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
TP53INP2Tumor protein p53-inducible nuclear protein 2. (221 aa)
CFLARCASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (482 aa)
ATG2AAutophagy-related protein 2 homolog A. (1943 aa)
WIPI2WD repeat domain phosphoinositide-interacting protein 2 isoform X1. (454 aa)
BADBcl2-associated agonist of cell death. (168 aa)
PRAP1Proline-rich acidic protein 1. (156 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (339 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
DAPK3Death-associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (439 aa)
RAB7ARas-related protein Rab-7a. (207 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2 isoform X1. (584 aa)
ATG16L1Autophagy-related protein 16-1 isoform X1. (607 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
IGBP1Immunoglobulin-binding protein 1 isoform X2. (341 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit 1. (315 aa)
RAB1ARas-related protein Rab-1A isoform X1. (205 aa)
VMP1Vacuole membrane protein 1 isoform X1. (406 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
BCL2Apoptosis regulator Bcl-2. (235 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GABARAPGamma-aminobutyric acid receptor-associated protein. (117 aa)
ATG4DCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (473 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
LOC101378833Insulin receptor substrate 2-like. (528 aa)
ZFYVE1Zinc finger FYVE domain-containing protein 1 isoform X1. (787 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
IRS4LOW QUALITY PROTEIN: insulin receptor substrate 4. (1307 aa)
EIF2AK4Eukaryotic translation initiation factor 2-alpha kinase 4. (1652 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SNAP29Synaptosomal-associated protein 29. (258 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
ATG101Autophagy-related protein 101. (218 aa)
BNIP3BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (194 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
RB1CC1RB1-inducible coiled-coil protein 1 isoform X1. (1593 aa)
RRAGCRas-related GTP-binding protein C isoform X1. (399 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (839 aa)
TSC2Tuberin isoform X1. (1813 aa)
MLST8Target of rapamycin complex subunit LST8. (326 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
HRASGTPase HRas isoform X1. (189 aa)
CTSDCathepsin D isoform X1; Belongs to the peptidase A1 family. (410 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
RRAGDRas-related GTP-binding protein D. (396 aa)
RPTORRegulatory-associated protein of mTOR isoform X1. (1335 aa)
RAB8ARas-related protein Rab-8A. (207 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
ATG14Beclin 1-associated autophagy-related key regulator. (510 aa)
ULK2Serine/threonine-protein kinase ULK2. (1036 aa)
SMCR8smith-Magenis syndrome chromosomal region candidate gene 8 protein. (936 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ATG10Ubiquitin-like-conjugating enzyme ATG10. (216 aa)
RRAGARas-related GTP-binding protein A. (313 aa)
WIPI1WD repeat domain phosphoinositide-interacting protein 1 isoform X1. (446 aa)
ERN1Serine/threonine-protein kinase/endoribonuclease IRE1. (975 aa)
RAB33BRas-related protein Rab-33B. (227 aa)
HMGB1High mobility group protein B1. (207 aa)
LAMP2Lysosome-associated membrane glycoprotein 2 isoform X1. (412 aa)
LOC101382346Cathepsin L1-like; Belongs to the peptidase C1 family. (333 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (920 aa)
RHEBGTP-binding protein Rheb isoform X1. (184 aa)
PRKAA1Non-specific serine/threonine protein kinase. (528 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
DAPK2Death-associated protein kinase 2; Belongs to the protein kinase superfamily. (365 aa)
IRS2Insulin receptor substrate 2. (1327 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
IRS1Insulin receptor substrate 1. (1233 aa)
RRASRas-related protein R-Ras. (218 aa)
AKT1S1Proline-rich AKT1 substrate 1. (310 aa)
BECN1Beclin-1. (448 aa)
LOC101364428Cathepsin L1-like; Belongs to the peptidase C1 family. (325 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2559 aa)
WDR41WD repeat-containing protein 41. (459 aa)
ATG4CCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (403 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (822 aa)
DEPTORDEP domain-containing mTOR-interacting protein isoform X1. (406 aa)
RRAGBRas-related GTP-binding protein B isoform X1. (374 aa)
LAMP1Lysosome-associated membrane glycoprotein 1 isoform X1. (416 aa)
GABARAPL1Gamma-aminobutyric acid receptor-associated protein-like 1. (117 aa)
MAPK9Mitogen-activated protein kinase. (427 aa)
SQSTM1Sequestosome-1. (439 aa)
ATG4BCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (393 aa)
DDIT4DNA damage-inducible transcript 4 protein. (231 aa)
MRASRas-related protein M-Ras. (208 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (358 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1. (1113 aa)
ATG4ACysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (398 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
LOC101367134GTPase HRas-like. (177 aa)
VAMP8Vesicle-associated membrane protein 8. (101 aa)
RRAS2Ras-related protein R-Ras2 isoform X1. (204 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
NRBF2Nuclear receptor-binding factor 2 isoform X1. (288 aa)
LOC101362126Cathepsin L1; Belongs to the peptidase C1 family. (334 aa)
ATG2BAutophagy-related protein 2 homolog B. (1990 aa)
LOC101368415Protein C9orf72 homolog. (481 aa)
RAB39BRas-related protein Rab-39B. (213 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1053 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (703 aa)
ATG16L2Autophagy-related protein 16-2. (620 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
MTMR4Myotubularin-related protein 4 isoform X1. (1209 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2758 aa)
MTMR3Myotubularin-related protein 3. (1231 aa)
NRASGTPase NRas. (189 aa)
TSC1Hamartin isoform X1. (1168 aa)
IGF1RTyrosine-protein kinase receptor. (1304 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
SH3GLB1endophilin-B1 isoform X1. (401 aa)
TANKTRAF family member-associated NF-kappa-B activator. (426 aa)
DAPK1Death-associated protein kinase 1. (1392 aa)
LOC101364724Cathepsin L1-like; Belongs to the peptidase C1 family. (334 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
GABARAPL2Gamma-aminobutyric acid receptor-associated protein-like 2. (117 aa)
TBK1Serine/threonine-protein kinase TBK1 isoform X1. (782 aa)
BECN2LOW QUALITY PROTEIN: beclin-2. (417 aa)
PIK3R4Phosphoinositide 3-kinase regulatory subunit 4. (1358 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
LOC101363616Transcription factor SPT20 homolog. (708 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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