STRINGSTRING
LAMTOR3 LAMTOR3 EIF4E EIF4E WNT11 WNT11 SLC7A5 SLC7A5 SEC13 SEC13 TTI1 TTI1 STRADB STRADB FZD1 FZD1 GRB2 GRB2 FNIP2 FNIP2 EIF4EBP1 EIF4EBP1 RPS6KA1 RPS6KA1 SESN2 SESN2 MAP2K2 MAP2K2 STK11 STK11 MIOS MIOS WNT7A WNT7A AKT1 AKT1 CLIP1 CLIP1 CAB39 CAB39 EIF4E2 EIF4E2 AKT2 AKT2 LOC101383455 LOC101383455 ATP6V1G1 ATP6V1G1 MAPK3 MAPK3 ATP6V1D ATP6V1D PIK3CD PIK3CD RPS6KB1 RPS6KB1 WNT8A WNT8A ATP6V1F ATP6V1F RNF152 RNF152 PIK3CA PIK3CA DVL2 DVL2 ATP6V1B1 ATP6V1B1 PRKCB PRKCB LAMTOR4 LAMTOR4 FZD9 FZD9 RHOA RHOA NPRL2 NPRL2 CAB39L CAB39L GATSL3 GATSL3 AKT3 AKT3 MAPK1 MAPK1 PIK3R3 PIK3R3 WNT10B WNT10B WNT1 WNT1 SGK1 SGK1 WNT2B WNT2B EIF4E1B EIF4E1B RPS6KA3 RPS6KA3 ATP6V1C2 ATP6V1C2 LPIN1 LPIN1 CHUK CHUK WNT8B WNT8B ATP6V1C1 ATP6V1C1 FZD6 FZD6 RRAGC RRAGC WNT10A WNT10A WNT6 WNT6 LAMTOR2 LAMTOR2 NPRL3 NPRL3 WDR24 WDR24 TSC2 TSC2 TELO2 TELO2 MLST8 MLST8 PDPK1 PDPK1 ATP6V1E2 ATP6V1E2 GSK3B GSK3B HRAS HRAS INS INS RICTOR RICTOR SKP2 SKP2 RRAGD RRAGD TBC1D7 TBC1D7 WNT16 WNT16 RPTOR RPTOR PIK3R2 PIK3R2 ULK2 ULK2 FLCN FLCN FZD5 FZD5 RPS6 RPS6 RRAGA RRAGA LOC101379441 LOC101379441 STRADA STRADA EIF4B EIF4B WNT5A WNT5A DVL3 DVL3 WNT5B WNT5B ATP6V1E1 ATP6V1E1 WNT9A WNT9A WNT3A WNT3A LAMTOR5 LAMTOR5 FZD2 FZD2 DVL1 DVL1 SOS2 SOS2 FNIP1 FNIP1 SEH1L SEH1L WNT2 WNT2 RHEB RHEB PRKAA1 PRKAA1 PRKCG PRKCG PTEN PTEN IRS1 IRS1 AKT1S1 AKT1S1 SOS1 SOS1 ATP6V1H ATP6V1H LRP6 LRP6 WNT3 WNT3 MTOR MTOR WNT9B WNT9B FZD3 FZD3 WNT4 WNT4 DEPTOR DEPTOR INSR INSR LPIN2 LPIN2 RRAGB RRAGB LOC101384010 LOC101384010 WDR59 WDR59 DDIT4 DDIT4 IGF1 IGF1 PIK3CB PIK3CB RPS6KA6 RPS6KA6 TNFRSF1A TNFRSF1A SLC3A2 SLC3A2 ATP6V1B2 ATP6V1B2 FZD4 FZD4 MAP2K1 MAP2K1 PRKAA2 PRKAA2 ATP6V1A ATP6V1A GRB10 GRB10 ATP6V1G2 ATP6V1G2 TNF TNF LOC101367134 LOC101367134 FZD10 FZD10 IKBKB IKBKB PRKCA PRKCA WNT7B WNT7B PIK3R1 PIK3R1 PRR5 PRR5 SLC38A9 SLC38A9 FZD8 FZD8 ATP6V1G3 ATP6V1G3 ULK1 ULK1 LAMTOR1 LAMTOR1 RAF1 RAF1 DEPDC5 DEPDC5 NRAS NRAS MAPKAP1 MAPKAP1 TSC1 TSC1 RPS6KA2 RPS6KA2 IGF1R IGF1R LOC101371328 LOC101371328 LPIN3 LPIN3 FZD7 FZD7 BRAF BRAF LRP5 LRP5 GATSL2 GATSL2 RPS6KB2 RPS6KB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LAMTOR3Ragulator complex protein LAMTOR3. (124 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SLC7A5Large neutral amino acids transporter small subunit 1. (506 aa)
SEC13Protein SEC13 homolog isoform X1; Belongs to the WD repeat SEC13 family. (322 aa)
TTI1TELO2-interacting protein 1 homolog. (1091 aa)
STRADBSTE20-related kinase adapter protein beta. (415 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (648 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
FNIP2Folliculin-interacting protein 2. (1119 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
SESN2Sestrin-2. (481 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (439 aa)
MIOSWD repeat-containing protein mio. (875 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CLIP1CAP-Gly domain-containing linker protein 1 isoform X1. (1438 aa)
CAB39Calcium-binding protein 39. (341 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2 isoform X1; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LOC101383455V-type proton ATPase subunit E 1-like isoform X1. (226 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ATP6V1DV-type proton ATPase subunit D. (247 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
RNF152E3 ubiquitin-protein ligase RNF152. (206 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X1. (734 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
LAMTOR4Ragulator complex protein LAMTOR4. (99 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (597 aa)
RHOATransforming protein RhoA isoform X1. (193 aa)
NPRL2Nitrogen permease regulator 2-like protein. (380 aa)
CAB39LCalcium-binding protein 39-like. (337 aa)
GATSL3GATS-like protein 3 isoform X1. (329 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
EIF4E1BEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (247 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (427 aa)
LPIN1Phosphatidate phosphatase LPIN1 isoform X1. (948 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
FZD6Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
RRAGCRas-related GTP-binding protein C isoform X1. (399 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
LAMTOR2Ragulator complex protein LAMTOR2 isoform X1. (125 aa)
NPRL3Nitrogen permease regulator 3-like protein isoform X1. (582 aa)
WDR24WD repeat-containing protein 24. (790 aa)
TSC2Tuberin isoform X1. (1813 aa)
TELO2Telomere length regulation protein TEL2 homolog. (837 aa)
MLST8Target of rapamycin complex subunit LST8. (326 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
ATP6V1E2V-type proton ATPase subunit E 2. (226 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
HRASGTPase HRas isoform X1. (189 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
RICTORRapamycin-insensitive companion of mTOR isoform X1. (1732 aa)
SKP2S-phase kinase-associated protein 2 isoform X1. (436 aa)
RRAGDRas-related GTP-binding protein D. (396 aa)
TBC1D7TBC1 domain family member 7 isoform X1. (293 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
RPTORRegulatory-associated protein of mTOR isoform X1. (1335 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
ULK2Serine/threonine-protein kinase ULK2. (1036 aa)
FLCNFolliculin. (579 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (590 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
RRAGARas-related GTP-binding protein A. (313 aa)
LOC101379441Ragulator complex protein LAMTOR5-like. (95 aa)
STRADASTE20-related kinase adapter protein alpha isoform X1. (431 aa)
EIF4BEukaryotic translation initiation factor 4B isoform X1. (610 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (716 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
ATP6V1E1V-type proton ATPase subunit E 1 isoform X1. (226 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
LAMTOR5Ragulator complex protein LAMTOR5. (91 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (693 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1333 aa)
FNIP1Folliculin-interacting protein 1 isoform X1. (1169 aa)
SEH1LNucleoporin SEH1 isoform X1; Belongs to the WD repeat SEC13 family. (421 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
RHEBGTP-binding protein Rheb isoform X1. (184 aa)
PRKAA1Non-specific serine/threonine protein kinase. (528 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
IRS1Insulin receptor substrate 1. (1233 aa)
AKT1S1Proline-rich AKT1 substrate 1. (310 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2559 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
DEPTORDEP domain-containing mTOR-interacting protein isoform X1. (406 aa)
INSRTyrosine-protein kinase receptor. (1381 aa)
LPIN2Phosphatidate phosphatase LPIN2. (939 aa)
RRAGBRas-related GTP-binding protein B isoform X1. (374 aa)
LOC101384010V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
WDR59WD repeat-containing protein 59. (974 aa)
DDIT4DNA damage-inducible transcript 4 protein. (231 aa)
IGF1Insulin-like growth factor I isoform X1. (187 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
RPS6KA6Ribosomal protein S6 kinase. (744 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (451 aa)
SLC3A24F2 cell-surface antigen heavy chain. (533 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
ATP6V1AV-type proton ATPase catalytic subunit A. (618 aa)
GRB10Growth factor receptor-bound protein 10. (586 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC101367134GTPase HRas-like. (177 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
PRR5Proline-rich protein 5. (389 aa)
SLC38A9Sodium-coupled neutral amino acid transporter 9 isoform X1. (559 aa)
FZD8Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (689 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1053 aa)
LAMTOR1Ragulator complex protein LAMTOR1 isoform X1. (174 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
DEPDC5DEP domain-containing protein 5. (1592 aa)
NRASGTPase NRas. (189 aa)
MAPKAP1Target of rapamycin complex 2 subunit MAPKAP1 isoform X1. (522 aa)
TSC1Hamartin isoform X1. (1168 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
IGF1RTyrosine-protein kinase receptor. (1304 aa)
LOC101371328LOW QUALITY PROTEIN: folliculin-like. (610 aa)
LPIN3Phosphatidate phosphatase LPIN3. (847 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
BRAFSerine/threonine-protein kinase B-raf. (772 aa)
LRP5Low-density lipoprotein receptor-related protein 5. (1451 aa)
GATSL2GATS-like protein 2 isoform X1. (330 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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