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EIF4E EIF4E CREB3 CREB3 ADIPOR1 ADIPOR1 SIRT1 SIRT1 RELA RELA EIF4EBP1 EIF4EBP1 SESN2 SESN2 ADCY3 ADCY3 STK11 STK11 AKT1 AKT1 PPARG PPARG CAMKK2 CAMKK2 EIF4E2 EIF4E2 AKT2 AKT2 PRKAB1 PRKAB1 ATF4 ATF4 PIK3CD PIK3CD RPS6KB1 RPS6KB1 ATG5 ATG5 PIK3CA PIK3CA TP53 TP53 PRKACA PRKACA LOC101378833 LOC101378833 FOXO1 FOXO1 ATG13 ATG13 CREB3L1 CREB3L1 IRS4 IRS4 AKT3 AKT3 PIK3R3 PIK3R3 PRKAG1 PRKAG1 ATG101 ATG101 SOD2 SOD2 CAMK4 CAMK4 EIF4E1B EIF4E1B NFKB1 NFKB1 RB1CC1 RB1CC1 PRKAG3 PRKAG3 PPARGC1A PPARGC1A CREB3L4 CREB3L4 TSC2 TSC2 ADCY9 ADCY9 HRAS HRAS INS INS RPTOR RPTOR PIK3R2 PIK3R2 CREB1 CREB1 CAT CAT APPL1 APPL1 LOC101376741 LOC101376741 SESN1 SESN1 ADIPOR2 ADIPOR2 LOC101382057 LOC101382057 PRKAG2 PRKAG2 RHEB RHEB PRKAA1 PRKAA1 IRS2 IRS2 IRS1 IRS1 ADCY8 ADCY8 AKT1S1 AKT1S1 MTOR MTOR INSR INSR IGF1 IGF1 PIK3CB PIK3CB ADIPOQ ADIPOQ PRKACB PRKACB CREB5 CREB5 PRKAA2 PRKAA2 BAX BAX ATF6B ATF6B EHMT2 EHMT2 LOC101367134 LOC101367134 ADCY2 ADCY2 KL KL PIK3R1 PIK3R1 CREB3L2 CREB3L2 EHMT1 EHMT1 PRKAB2 PRKAB2 ULK1 ULK1 ADCY5 ADCY5 NRAS NRAS ADCY6 ADCY6 TSC1 TSC1 ADCY4 ADCY4 IGF1R IGF1R ADCY7 ADCY7 ATF2 ATF2 ADCY1 ADCY1 SESN3 SESN3 RPS6KB2 RPS6KB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (352 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (740 aa)
RELATranscription factor p65. (539 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
SESN2Sestrin-2. (481 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (439 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (529 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2 isoform X1. (584 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2 isoform X1; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
LOC101378833Insulin receptor substrate 2-like. (528 aa)
FOXO1Forkhead box protein O1. (662 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
IRS4LOW QUALITY PROTEIN: insulin receptor substrate 4. (1307 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X1. (337 aa)
ATG101Autophagy-related protein 101. (218 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV; Belongs to the protein kinase superfamily. (470 aa)
EIF4E1BEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (247 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
RB1CC1RB1-inducible coiled-coil protein 1 isoform X1. (1593 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (464 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (803 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (393 aa)
TSC2Tuberin isoform X1. (1813 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
HRASGTPase HRas isoform X1. (189 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
RPTORRegulatory-associated protein of mTOR isoform X1. (1335 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (541 aa)
APPL1DCC-interacting protein 13-alpha. (708 aa)
LOC101376741Forkhead box protein O3. (453 aa)
SESN1Sestrin-1 isoform X1. (551 aa)
ADIPOR2Adiponectin receptor protein 2. (386 aa)
LOC101382057Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (183 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2 isoform X1. (569 aa)
RHEBGTP-binding protein Rheb isoform X1. (184 aa)
PRKAA1Non-specific serine/threonine protein kinase. (528 aa)
IRS2Insulin receptor substrate 2. (1327 aa)
IRS1Insulin receptor substrate 1. (1233 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
AKT1S1Proline-rich AKT1 substrate 1. (310 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2559 aa)
INSRTyrosine-protein kinase receptor. (1381 aa)
IGF1Insulin-like growth factor I isoform X1. (187 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
ADIPOQAdiponectin isoform X1. (266 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (358 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (369 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta isoform X2. (711 aa)
EHMT2Histone-lysine N-methyltransferase EHMT2 isoform X1. (1268 aa)
LOC101367134GTPase HRas-like. (177 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
KLKlotho. (1010 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (519 aa)
EHMT1Histone-lysine N-methyltransferase EHMT1. (1267 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2 isoform X1. (272 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1053 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
NRASGTPase NRas. (189 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
TSC1Hamartin isoform X1. (1168 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
IGF1RTyrosine-protein kinase receptor. (1304 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
SESN3Sestrin-3 isoform X1. (496 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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