STRINGSTRING
CLPB CLPB EIF4EBP2 EIF4EBP2 SIRT1 SIRT1 ADCY3 ADCY3 AKT1 AKT1 AKT2 AKT2 PRKAB1 PRKAB1 PIK3CD PIK3CD RPS6KB1 RPS6KB1 HDAC2 HDAC2 ATG5 ATG5 PIK3CA PIK3CA PRKACA PRKACA LOC101378833 LOC101378833 FOXO1 FOXO1 IRS4 IRS4 AKT3 AKT3 PIK3R3 PIK3R3 PRKAG1 PRKAG1 SOD2 SOD2 PRKAG3 PRKAG3 ADCY9 ADCY9 HRAS HRAS INS INS RPTOR RPTOR PIK3R2 PIK3R2 CAT CAT SOD1 SOD1 HDAC1 HDAC1 LOC101376741 LOC101376741 LOC101382057 LOC101382057 PRKAG2 PRKAG2 PRKAA1 PRKAA1 HSPA2 HSPA2 IRS2 IRS2 IRS1 IRS1 ADCY8 ADCY8 AKT1S1 AKT1S1 MTOR MTOR INSR INSR IGF1 IGF1 PIK3CB PIK3CB PRKACB PRKACB HSPA8 HSPA8 PRKAA2 PRKAA2 FOXA2 FOXA2 LOC101376406 LOC101376406 LOC101367134 LOC101367134 ADCY2 ADCY2 PIK3R1 PIK3R1 PRKAB2 PRKAB2 ADCY5 ADCY5 LOC101375744 LOC101375744 NRAS NRAS ADCY6 ADCY6 ADCY4 ADCY4 HSPA6 HSPA6 IGF1R IGF1R ADCY7 ADCY7 ADCY1 ADCY1 CRYAB CRYAB HSPA1L HSPA1L RPS6KB2 RPS6KB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CLPBCaseinolytic peptidase B protein homolog isoform X1. (707 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E-binding protein 2. (120 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (740 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
LOC101378833Insulin receptor substrate 2-like. (528 aa)
FOXO1Forkhead box protein O1. (662 aa)
IRS4LOW QUALITY PROTEIN: insulin receptor substrate 4. (1307 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X1. (337 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (464 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
HRASGTPase HRas isoform X1. (189 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
RPTORRegulatory-associated protein of mTOR isoform X1. (1335 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (541 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
LOC101376741Forkhead box protein O3. (453 aa)
LOC101382057Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (183 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2 isoform X1. (569 aa)
PRKAA1Non-specific serine/threonine protein kinase. (528 aa)
HSPA2Heat shock-related 70 kDa protein 2; Belongs to the heat shock protein 70 family. (638 aa)
IRS2Insulin receptor substrate 2. (1327 aa)
IRS1Insulin receptor substrate 1. (1233 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
AKT1S1Proline-rich AKT1 substrate 1. (310 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2559 aa)
INSRTyrosine-protein kinase receptor. (1381 aa)
IGF1Insulin-like growth factor I isoform X1. (187 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (358 aa)
HSPA8Heat shock cognate 71 kDa protein isoform X1; Belongs to the heat shock protein 70 family. (654 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
FOXA2Hepatocyte nuclear factor 3-beta. (463 aa)
LOC101376406Heat shock 70 kDa protein 1; Belongs to the heat shock protein 70 family. (641 aa)
LOC101367134GTPase HRas-like. (177 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2 isoform X1. (272 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
LOC101375744LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like; Belongs to the heat shock protein 70 family. (656 aa)
NRASGTPase NRas. (189 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
HSPA6LOW QUALITY PROTEIN: heat shock 70 kDa protein 6; Belongs to the heat shock protein 70 family. (688 aa)
IGF1RTyrosine-protein kinase receptor. (1304 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
CRYABAlpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
HSPA1LHeat shock 70 kDa protein 1-like isoform X1; Belongs to the heat shock protein 70 family. (661 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.