STRINGSTRING
KCNMB1 KCNMB1 NPR2 NPR2 CALCRL CALCRL CACNA1S CACNA1S AVPR1B AVPR1B MYL9 MYL9 PPP1CA PPP1CA PLCB3 PLCB3 GNA12 GNA12 GUCY1A3 GUCY1A3 CALM1 CALM1 ADM ADM MRVI1 MRVI1 PPP1CB PPP1CB ADCY3 ADCY3 MAP2K2 MAP2K2 PPP1CC PPP1CC NPPC NPPC PPP1R14A PPP1R14A PLA2G1B PLA2G1B ARAF ARAF CACNA1F CACNA1F GNAQ GNAQ LOC101371862 LOC101371862 PLA2G2D PLA2G2D PLA2G2F PLA2G2F MAPK3 MAPK3 PLA2G5 PLA2G5 AVP AVP ADRA1D ADRA1D PRKCQ PRKCQ KCNMB2 KCNMB2 PRKCB PRKCB PRKACA PRKACA RHOA RHOA PLA2G3 PLA2G3 PLA2G4E PLA2G4E PLA2G4F PLA2G4F PLA2G4D PLA2G4D PLCB2 PLCB2 MAPK1 MAPK1 ADORA2A ADORA2A CALM3 CALM3 PTGIR PTGIR LOC101373722 LOC101373722 LOC101372085 LOC101372085 MYL6B MYL6B ROCK2 ROCK2 NPR1 NPR1 ARHGEF11 ARHGEF11 ADCY9 ADCY9 KCNMA1 KCNMA1 CALM2 CALM2 PRKCE PRKCE MYLK3 MYLK3 EDNRA EDNRA ADRA1B ADRA1B AGT AGT PPP1R12C PPP1R12C ADORA2B ADORA2B GNA13 GNA13 KCNMB4 KCNMB4 EDN2 EDN2 CACNA1C CACNA1C PLA2G12B PLA2G12B CALML6 CALML6 LOC101377802 LOC101377802 RAMP3 RAMP3 PRKCG PRKCG ACTA2 ACTA2 ADCY8 ADCY8 MYH14 MYH14 RAMP1 RAMP1 RAMP2 RAMP2 NPPA NPPA NPPB NPPB PLA2G12A PLA2G12A CACNA1D CACNA1D CALML3 CALML3 PRKCH PRKCH CALML4 CALML4 ARHGEF12 ARHGEF12 ADRA1A ADRA1A LOC101381707 LOC101381707 PRKACB PRKACB GNAS GNAS LOC105757053 LOC105757053 EDN3 EDN3 GUCY1A2 GUCY1A2 MAP2K1 MAP2K1 PLCB1 PLCB1 ADCY2 ADCY2 LOC101368405 LOC101368405 LOC101369097 LOC101369097 PRKCA PRKCA ITPR2 ITPR2 AVPR1A AVPR1A GUCY1B3 GUCY1B3 GNA11 GNA11 RAF1 RAF1 MYLK MYLK ADCY5 ADCY5 PLA2G2C PLA2G2C MYH10 MYH10 ITPR1 ITPR1 LOC101365290 LOC101365290 ACTG2 ACTG2 PLA2G4B PLA2G4B MYL6 MYL6 ADCY6 ADCY6 ADCY4 ADCY4 EDN1 EDN1 LOC101386691 LOC101386691 PLA2G4A PLA2G4A AGTR1 AGTR1 PPP1R12A PPP1R12A CALD1 CALD1 MYLK2 MYLK2 ARHGEF1 ARHGEF1 MYLK4 MYLK4 ADCY7 ADCY7 ITPR3 ITPR3 MYH11 MYH11 ADCY1 ADCY1 ROCK1 ROCK1 PLA2G6 PLA2G6 CALML5 CALML5 PRKCD PRKCD BRAF BRAF PLCB4 PLCB4 CALCB CALCB LOC101373053 LOC101373053 MYH9 MYH9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KCNMB1Calcium-activated potassium channel subunit beta-1. (191 aa)
NPR2Guanylate cyclase. (1047 aa)
CALCRLCalcitonin gene-related peptide type 1 receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (420 aa)
MYL9Myosin regulatory light polypeptide 9 isoform X1. (172 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12 isoform X1. (382 aa)
GUCY1A3Guanylate cyclase soluble subunit alpha-3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
CALM1Calmodulin isoform X1; Belongs to the calmodulin family. (155 aa)
ADMADM. (188 aa)
MRVI1Protein MRVI1 isoform X1. (912 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
NPPCC-type natriuretic peptide. (126 aa)
PPP1R14AProtein phosphatase 1 regulatory subunit 14A. (147 aa)
PLA2G1BPhospholipase A(2). (147 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1983 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
LOC101371862Phospholipase A(2). (142 aa)
PLA2G2DPhospholipase A(2). (145 aa)
PLA2G2FPhospholipase A(2). (210 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PLA2G5Phospholipase A(2). (137 aa)
AVPVasopressin-neurophysin 2-copeptin; Belongs to the vasopressin/oxytocin family. (166 aa)
ADRA1Dalpha-1D adrenergic receptor. (569 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
KCNMB2Calcium-activated potassium channel subunit beta-2. (235 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
RHOATransforming protein RhoA isoform X1. (193 aa)
PLA2G3Group 3 secretory phospholipase A2. (522 aa)
PLA2G4EPhospholipase A2. (864 aa)
PLA2G4FPhospholipase A2. (875 aa)
PLA2G4DPhospholipase A2. (817 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (409 aa)
CALM3Calmodulin isoform X2; Belongs to the calmodulin family. (149 aa)
PTGIRProstacyclin receptor; Belongs to the G-protein coupled receptor 1 family. (408 aa)
LOC101373722Calmodulin-alpha-like; Belongs to the calmodulin family. (149 aa)
LOC101372085calmodulin-A-like; Belongs to the calmodulin family. (271 aa)
MYL6BMyosin light chain 6B. (209 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
NPR1Guanylate cyclase. (1080 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1581 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
KCNMA1Calcium-activated potassium channel subunit alpha-1 isoform X1. (1261 aa)
CALM2Calmodulin isoform X1; Belongs to the calmodulin family. (155 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
MYLK3Myosin light chain kinase 3. (807 aa)
EDNRAEndothelin-1 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
ADRA1Balpha-1B adrenergic receptor. (518 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (774 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13 isoform X1. (377 aa)
KCNMB4Calcium-activated potassium channel subunit beta-4. (210 aa)
EDN2Endothelin-2 isoform X1. (179 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2190 aa)
PLA2G12BGroup XIIB secretory phospholipase A2-like protein isoform X1. (195 aa)
CALML6Calmodulin-like protein 6. (167 aa)
LOC101377802Phospholipase A(2). (168 aa)
RAMP3Receptor activity-modifying protein 3. (149 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ACTA2Actin, aortic smooth muscle isoform X1. (377 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
MYH14Myosin-14 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2037 aa)
RAMP1Receptor activity-modifying protein 1. (148 aa)
RAMP2Receptor activity-modifying protein 2. (176 aa)
NPPANatriuretic peptides A. (152 aa)
NPPBNatriuretic peptides B. (132 aa)
PLA2G12AGroup XIIA secretory phospholipase A2. (190 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
CALML3Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like protein 4. (197 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1524 aa)
ADRA1Aalpha-1A adrenergic receptor. (465 aa)
LOC101381707Cytochrome P450 4A11. (295 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (358 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1015 aa)
LOC105757053Neuroendocrine secretory protein 55. (246 aa)
EDN3Endothelin-3. (198 aa)
GUCY1A2Guanylate cyclase soluble subunit alpha-2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (723 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
LOC101368405Calcitonin-like isoform X1. (147 aa)
LOC101369097Calcitonin receptor-stimulating peptide 1. (126 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2639 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (421 aa)
GUCY1B3Guanylate cyclase soluble subunit beta-1 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (643 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (301 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
MYLKMyosin light chain kinase, smooth muscle isoform X1. (1998 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
PLA2G2CPhospholipase A(2). (170 aa)
MYH10Myosin-10 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2758 aa)
LOC101365290Guanylate cyclase soluble subunit beta-2-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (707 aa)
ACTG2Actin, gamma-enteric smooth muscle isoform X1. (376 aa)
PLA2G4BPhospholipase A2. (782 aa)
MYL6Myosin light polypeptide 6 isoform X1. (160 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
EDN1Endothelin-1 isoform X1. (227 aa)
LOC101386691Calmodulin-like; Belongs to the calmodulin family. (176 aa)
PLA2G4APhospholipase A2. (749 aa)
AGTR1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1029 aa)
CALD1Caldesmon. (830 aa)
MYLK2Myosin light chain kinase 2, skeletal/cardiac muscle isoform X1. (686 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (974 aa)
MYLK4Myosin light chain kinase family member 4. (681 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3 isoform X1. (2674 aa)
MYH11Myosin-11 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2056 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
PLA2G685/88 kDa calcium-independent phospholipase A2. (836 aa)
CALML5Calmodulin-like protein 5. (149 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
BRAFSerine/threonine-protein kinase B-raf. (772 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
CALCBCalcitonin gene-related peptide 2 isoform X1. (131 aa)
LOC101373053LOW QUALITY PROTEIN: potassium channel subfamily U member 1-like. (692 aa)
MYH9Myosin-9 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1981 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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