STRINGSTRING
STIM1 STIM1 GP5 GP5 LCP2 LCP2 PLCG2 PLCG2 COL3A1 COL3A1 TLN1 TLN1 GNAI1 GNAI1 PPP1CA PPP1CA RASGRP2 RASGRP2 PLCB3 PLCB3 COL1A2 COL1A2 ACTB ACTB FERMT3 FERMT3 FGG FGG FGA FGA FGB FGB GUCY1A3 GUCY1A3 PPP1CB PPP1CB ADCY3 ADCY3 COL1A1 COL1A1 TBXA2R TBXA2R GP9 GP9 AKT1 AKT1 PPP1CC PPP1CC ORAI1 ORAI1 AKT2 AKT2 GNAQ GNAQ MAPK3 MAPK3 PIK3CD PIK3CD LOC101366571 LOC101366571 PIK3CA PIK3CA PIK3R6 PIK3R6 PIK3R5 PIK3R5 PRKACA PRKACA RHOA RHOA GNAI2 GNAI2 F2 F2 PLA2G4E PLA2G4E PLA2G4F PLA2G4F PLA2G4D PLA2G4D SNAP23 SNAP23 PLCB2 PLCB2 AKT3 AKT3 MAPK1 MAPK1 PIK3R3 PIK3R3 ARHGAP35 ARHGAP35 PTGIR PTGIR VASP VASP RAP1A RAP1A ITGB1 ITGB1 ROCK2 ROCK2 ADCY9 ADCY9 MYLK3 MYLK3 APBB1IP APBB1IP PIK3R2 PIK3R2 P2RY1 P2RY1 P2RY12 P2RY12 GP6 GP6 GNA13 GNA13 RAP1B RAP1B FYN FYN GNAI3 GNAI3 PRKG2 PRKG2 ITGA2B ITGA2B PRKCZ PRKCZ FCER1G FCER1G MAPK11 MAPK11 MAPK12 MAPK12 RASGRP1 RASGRP1 MAPK13 MAPK13 MAPK14 MAPK14 ADCY8 ADCY8 SYK SYK ITGA2 ITGA2 ITGB3 ITGB3 PTGS1 PTGS1 PIK3CG PIK3CG LOC101374641 LOC101374641 LOC101375321 LOC101375321 ARHGEF12 ARHGEF12 PIK3CB PIK3CB F2R F2R PRKACB PRKACB VWF VWF GNAS GNAS LOC105757053 LOC105757053 TBXAS1 TBXAS1 GUCY1A2 GUCY1A2 LYN LYN PLCB1 PLCB1 ADCY2 ADCY2 VAMP8 VAMP8 ITPR2 ITPR2 P2RX1 P2RX1 PIK3R1 PIK3R1 GUCY1B3 GUCY1B3 MYLK MYLK ADCY5 ADCY5 GP1BA GP1BA LOC105757317 LOC105757317 ITPR1 ITPR1 LOC101365290 LOC101365290 PLA2G4B PLA2G4B ADCY6 ADCY6 ADCY4 ADCY4 F2RL3 F2RL3 PLA2G4A PLA2G4A PPP1R12A PPP1R12A MYLK2 MYLK2 SRC SRC ARHGEF1 ARHGEF1 MYLK4 MYLK4 ADCY7 ADCY7 ITPR3 ITPR3 NOS3 NOS3 PRKCI PRKCI ADCY1 ADCY1 ROCK1 ROCK1 TLN2 TLN2 PLCB4 PLCB4 GP1BB GP1BB BTK BTK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STIM1Stromal interaction molecule 1 isoform X1. (796 aa)
GP5Platelet glycoprotein V. (573 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
COL3A1Collagen alpha-1(III) chain. (1466 aa)
TLN1Talin-1. (2541 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (359 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
RASGRP2RAS guanyl-releasing protein 2. (608 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
COL1A2Collagen alpha-2(I) chain. (1367 aa)
ACTBActin, cytoplasmic 1 isoform X2. (375 aa)
FERMT3Fermitin family homolog 3. (663 aa)
FGGFibrinogen gamma chain isoform X1. (445 aa)
FGAFibrinogen alpha chain. (869 aa)
FGBFibrinogen beta chain isoform X1. (495 aa)
GUCY1A3Guanylate cyclase soluble subunit alpha-3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
COL1A1Collagen alpha-1(I) chain. (1460 aa)
TBXA2RThromboxane A2 receptor; Belongs to the G-protein coupled receptor 1 family. (343 aa)
GP9Platelet glycoprotein IX. (177 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
ORAI1LOW QUALITY PROTEIN: calcium release-activated calcium channel protein 1. (405 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
LOC101366571Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (755 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5. (875 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
RHOATransforming protein RhoA isoform X1. (193 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform X1. (436 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
PLA2G4EPhospholipase A2. (864 aa)
PLA2G4FPhospholipase A2. (875 aa)
PLA2G4DPhospholipase A2. (817 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
ARHGAP35Rho GTPase-activating protein 35. (1500 aa)
PTGIRProstacyclin receptor; Belongs to the G-protein coupled receptor 1 family. (408 aa)
VASPVasodilator-stimulated phosphoprotein isoform X1; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (381 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
MYLK3Myosin light chain kinase 3. (807 aa)
APBB1IPAmyloid beta A4 precursor protein-binding family B member 1-interacting protein. (663 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
P2RY1P2Y purinoceptor 1; Belongs to the G-protein coupled receptor 1 family. (374 aa)
P2RY12P2Y purinoceptor 12. (339 aa)
GP6Platelet glycoprotein VI. (338 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13 isoform X1. (377 aa)
RAP1BRas-related protein Rap-1b isoform X1. (184 aa)
FYNTyrosine-protein kinase. (537 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
ITGA2BIntegrin alpha-IIb isoform X1; Belongs to the integrin alpha chain family. (1036 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (86 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
RASGRP1RAS guanyl-releasing protein 1 isoform X1. (797 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
SYKTyrosine-protein kinase. (635 aa)
ITGA2Integrin alpha-2; Belongs to the integrin alpha chain family. (1179 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
PTGS1Prostaglandin G/H synthase 1 isoform X1. (632 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1121 aa)
LOC101374641Myosin regulatory light polypeptide 9 isoform X1. (178 aa)
LOC101375321Myosin regulatory light chain 12B isoform X1. (172 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1524 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (358 aa)
VWFVon Willebrand factor isoform X1. (2813 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1015 aa)
LOC105757053Neuroendocrine secretory protein 55. (246 aa)
TBXAS1thromboxane-A synthase isoform X1; Belongs to the cytochrome P450 family. (533 aa)
GUCY1A2Guanylate cyclase soluble subunit alpha-2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (723 aa)
LYNTyrosine-protein kinase. (512 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
VAMP8Vesicle-associated membrane protein 8. (101 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2639 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
GUCY1B3Guanylate cyclase soluble subunit beta-1 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (643 aa)
MYLKMyosin light chain kinase, smooth muscle isoform X1. (1998 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
GP1BAPlatelet glycoprotein Ib alpha chain. (547 aa)
LOC105757317Mucin-1-like. (774 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2758 aa)
LOC101365290Guanylate cyclase soluble subunit beta-2-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (707 aa)
PLA2G4BPhospholipase A2. (782 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
F2RL3Proteinase-activated receptor 4 isoform X1; Belongs to the G-protein coupled receptor 1 family. (392 aa)
PLA2G4APhospholipase A2. (749 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1029 aa)
MYLK2Myosin light chain kinase 2, skeletal/cardiac muscle isoform X1. (686 aa)
SRCTyrosine-protein kinase. (553 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (974 aa)
MYLK4Myosin light chain kinase family member 4. (681 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3 isoform X1. (2674 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1208 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (627 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
TLN2Talin-2 isoform X1. (2557 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
GP1BBPlatelet glycoprotein Ib beta chain. (211 aa)
BTKTyrosine-protein kinase. (687 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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