STRINGSTRING
MAPK10 MAPK10 CBLB CBLB PPP3CA PPP3CA PAK1 PAK1 PLCG2 PLCG2 IKBKE IKBKE NFATC3 NFATC3 CASP8 CASP8 RELA RELA CALM1 CALM1 AKT1 AKT1 CCL17 CCL17 CCL22 CCL22 AKT2 AKT2 MAPK3 MAPK3 IL6 IL6 PIK3CD PIK3CD PPP3R1 PPP3R1 PIK3CA PIK3CA RHOA RHOA KSR1 KSR1 NFKBIA NFKBIA IL1B IL1B AKT3 AKT3 MAPK1 MAPK1 PIK3R3 PIK3R3 PLK3 PLK3 RELB RELB CALM3 CALM3 BCL3 BCL3 LOC101373722 LOC101373722 IL17D IL17D IL2 IL2 LOC101372085 LOC101372085 STAT2 STAT2 IL23A IL23A NFKB1 NFKB1 NFKB2 NFKB2 CHUK CHUK IRF9 IRF9 NFATC4 NFATC4 EGR3 EGR3 CALM2 CALM2 LSP1 LSP1 HRAS HRAS PIK3R2 PIK3R2 IL12B IL12B PTGS2 PTGS2 MDM2 MDM2 IL12A IL12A NLRP3 NLRP3 MAP3K14 MAP3K14 CALML6 CALML6 CLEC4E CLEC4E CLEC4D CLEC4D FCER1G FCER1G CYLD CYLD MAPK11 MAPK11 MAPK12 MAPK12 MAPK13 MAPK13 MAPK14 MAPK14 MALT1 MALT1 SYK SYK RRAS RRAS PTPN11 PTPN11 CARD9 CARD9 CALML3 CALML3 CD209 CD209 CALML4 CALML4 ARHGEF12 ARHGEF12 CLEC1B CLEC1B CLEC7A CLEC7A MAPK9 MAPK9 NFATC1 NFATC1 MRAS MRAS PIK3CB PIK3CB BCL10 BCL10 PPP3R2 PPP3R2 NFATC2 NFATC2 JUN JUN TNF TNF LOC101367134 LOC101367134 RRAS2 RRAS2 IKBKB IKBKB ITPR2 ITPR2 PIK3R1 PIK3R1 MAPKAPK2 MAPKAPK2 IL10 IL10 RAF1 RAF1 ITPR1 ITPR1 NRAS NRAS STAT1 STAT1 PPP3CC PPP3CC LOC101386691 LOC101386691 EGR2 EGR2 PPP3CB PPP3CB LOC101374328 LOC101374328 SRC SRC IRF1 IRF1 MAPK8 MAPK8 ITPR3 ITPR3 CALML5 CALML5 PRKCD PRKCD IKBKG IKBKG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK10Mitogen-activated protein kinase. (464 aa)
CBLBE3 ubiquitin-protein ligase CBL-B. (982 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon. (718 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1072 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
RELATranscription factor p65. (539 aa)
CALM1Calmodulin isoform X1; Belongs to the calmodulin family. (155 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CCL17C-C motif chemokine 17. (99 aa)
CCL22C-C motif chemokine. (93 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
IL6Interleukin-6 isoform X1. (212 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PPP3R1Calcineurin subunit B type 1 isoform X1. (170 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RHOATransforming protein RhoA isoform X1. (193 aa)
KSR1Kinase suppressor of Ras 1. (876 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
PLK3Serine/threonine-protein kinase PLK. (698 aa)
RELBTranscription factor RelB. (566 aa)
CALM3Calmodulin isoform X2; Belongs to the calmodulin family. (149 aa)
BCL3B-cell lymphoma 3 protein. (455 aa)
LOC101373722Calmodulin-alpha-like; Belongs to the calmodulin family. (149 aa)
IL17Dinterleukin-17D. (202 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
LOC101372085calmodulin-A-like; Belongs to the calmodulin family. (271 aa)
STAT2Signal transducer and activator of transcription. (854 aa)
IL23AInterleukin-23 subunit alpha. (209 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit. (900 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
IRF9Interferon regulatory factor 9 isoform X1. (484 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4 isoform X1. (930 aa)
EGR3Early growth response protein 3 isoform X1. (387 aa)
CALM2Calmodulin isoform X1; Belongs to the calmodulin family. (155 aa)
LSP1Lymphocyte-specific protein 1. (361 aa)
HRASGTPase HRas isoform X1. (189 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
NLRP3NACHT, LRR and PYD domains-containing protein 3 isoform X1. (1034 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (955 aa)
CALML6Calmodulin-like protein 6. (167 aa)
CLEC4EC-type lectin domain family 4 member E. (219 aa)
CLEC4DC-type lectin domain family 4 member D. (209 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (86 aa)
CYLDUbiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family. (956 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MALT1Mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1. (850 aa)
SYKTyrosine-protein kinase. (635 aa)
RRASRas-related protein R-Ras. (218 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
CARD9Caspase recruitment domain-containing protein 9. (536 aa)
CALML3Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
CD209CD209 antigen isoform X1. (249 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like protein 4. (197 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1524 aa)
CLEC1BC-type lectin domain family 1 member B. (227 aa)
CLEC7AC-type lectin domain family 7 member A isoform X1. (248 aa)
MAPK9Mitogen-activated protein kinase. (427 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (823 aa)
MRASRas-related protein M-Ras. (208 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
BCL10B-cell lymphoma/leukemia 10 isoform X1. (233 aa)
PPP3R2Calcineurin subunit B type 2. (170 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (920 aa)
JUNTranscription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC101367134GTPase HRas-like. (177 aa)
RRAS2Ras-related protein R-Ras2 isoform X1. (204 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2639 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
MAPKAPK2MAP kinase-activated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. (402 aa)
IL10Interleukin-10. (178 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2758 aa)
NRASGTPase NRas. (189 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
PPP3CCSerine/threonine-protein phosphatase. (534 aa)
LOC101386691Calmodulin-like; Belongs to the calmodulin family. (176 aa)
EGR2E3 SUMO-protein ligase EGR2 isoform X1. (484 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
LOC101374328Tyrosine-protein phosphatase non-receptor type 11-like. (581 aa)
SRCTyrosine-protein kinase. (553 aa)
IRF1Interferon regulatory factor. (338 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3 isoform X1. (2674 aa)
CALML5Calmodulin-like protein 5. (149 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (457 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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