STRINGSTRING
CNTFR CNTFR IL11RA IL11RA STAT4 STAT4 STAM STAM BCL2L1 BCL2L1 LOC101370075 LOC101370075 CCND1 CCND1 GRB2 GRB2 IL22RA1 IL22RA1 CSF3 CSF3 SOCS7 SOCS7 PIAS4 PIAS4 AKT1 AKT1 AKT2 AKT2 LOC101363775 LOC101363775 IL2RG IL2RG IL4R IL4R CTF1 CTF1 IL21R IL21R IL6 IL6 EP300 EP300 PIK3CD PIK3CD LEP LEP BCL2 BCL2 PIK3CA PIK3CA PIAS3 PIAS3 TYK2 TYK2 EPOR EPOR EPO EPO IL27RA IL27RA CISH CISH OSM OSM AKT3 AKT3 PIK3R3 PIK3R3 MPL MPL SOCS1 SOCS1 IL17D IL17D TSLP TSLP IL21 IL21 IL2 IL2 STAT6 STAT6 STAT2 STAT2 IL23A IL23A IRF9 IRF9 SOCS6 SOCS6 CSF3R CSF3R PDGFRB PDGFRB CREBBP CREBBP IL9R IL9R SOCS5 SOCS5 HRAS HRAS LIFR LIFR OSMR OSMR IL7R IL7R MCL1 MCL1 JAK3 JAK3 PIK3R2 PIK3R2 IL12RB1 IL12RB1 IL12B IL12B SOCS4 SOCS4 IL11 IL11 IL9 IL9 IFNB1 IFNB1 LOC101374322 LOC101374322 LOC101374610 LOC101374610 LOC101379735 LOC101379735 LOC101371706 LOC101371706 IL15 IL15 IL22 IL22 IL12A IL12A IFNAR2 IFNAR2 IL10RB IL10RB IFNAR1 IFNAR1 JAK2 JAK2 SOS2 SOS2 CCND3 CCND3 IL4 IL4 IL5 IL5 IL13 IL13 CSF2 CSF2 PTPN2 PTPN2 PIAS2 PIAS2 GHR GHR CNTF CNTF PIM1 PIM1 SOS1 SOS1 IL22RA2 IL22RA2 IFNGR1 IFNGR1 IL20RA IL20RA PTPN11 PTPN11 STAT5A STAT5A STAT3 STAT3 CSF2RB CSF2RB IL2RB IL2RB MTOR MTOR IL15RA IL15RA IL13RA2 IL13RA2 LOC101381320 LOC101381320 IFNA5 IFNA5 LOC101377641 LOC101377641 IFNE IFNE PIK3CB PIK3CB PTPN6 PTPN6 PDGFA PDGFA IL20RB IL20RB IL10RA IL10RA IL23R IL23R IL12RB2 IL12RB2 STAM2 STAM2 LOC101367134 LOC101367134 IL20 IL20 IL24 IL24 IL19 IL19 CCND2 CCND2 PIK3R1 PIK3R1 IL6ST IL6ST IL7 IL7 SOCS3 SOCS3 IFNG IFNG IFNK IFNK IL10 IL10 LOC101376217 LOC101376217 PRL PRL IFNL1 IFNL1 IFNLR1 IFNLR1 RAF1 RAF1 PDGFRA PDGFRA LOC101386269 LOC101386269 PDGFB PDGFB IL5RA IL5RA CSF2RA CSF2RA LOC105757391 LOC105757391 IL3RA IL3RA CRLF2 CRLF2 LIF LIF SOCS2 SOCS2 STAT1 STAT1 LOC105757531 LOC105757531 IL6R IL6R IL13RA1 IL13RA1 THPO THPO LOC101374328 LOC101374328 FHL1 FHL1 CDKN1A CDKN1A MYC MYC EGF EGF LOC101382582 LOC101382582 STAT5B STAT5B IL2RA IL2RA LOC101369776 LOC101369776 LEPR LEPR JAK1 JAK1 LOC101379383 LOC101379383 PIAS1 PIAS1 PRLR PRLR EGFR EGFR
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CNTFRCiliary neurotrophic factor receptor subunit alpha. (371 aa)
IL11RAInterleukin-11 receptor subunit alpha isoform X1. (422 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
STAMSignal transducing adapter molecule 1 isoform X1. (536 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
LOC101370075Aldehyde oxidase. (1338 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
IL22RA1Interleukin-22 receptor subunit alpha-1. (580 aa)
CSF3Granulocyte colony-stimulating factor. (195 aa)
SOCS7Suppressor of cytokine signaling 7 isoform X1. (578 aa)
PIAS4E3 SUMO-protein ligase PIAS4. (509 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LOC101363775Interferon lambda-3. (192 aa)
IL2RGCytokine receptor common subunit gamma. (374 aa)
IL4RInterleukin-4 receptor subunit alpha. (796 aa)
CTF1Cardiotrophin-1 isoform X1. (201 aa)
IL21RInterleukin-21 receptor. (542 aa)
IL6Interleukin-6 isoform X1. (212 aa)
EP300Histone acetyltransferase p300. (2421 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
BCL2Apoptosis regulator Bcl-2. (235 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PIAS3E3 SUMO-protein ligase PIAS3. (628 aa)
TYK2Tyrosine-protein kinase. (1203 aa)
EPORErythropoietin receptor; Receptor for erythropoietin. (509 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
IL27RAInterleukin-27 receptor subunit alpha. (654 aa)
CISHCytokine-inducible SH2-containing protein. (257 aa)
OSMoncostatin-M. (238 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
MPLThrombopoietin receptor. (679 aa)
SOCS1Suppressor of cytokine signaling 1. (216 aa)
IL17Dinterleukin-17D. (202 aa)
TSLPThymic stromal lymphopoietin. (163 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
STAT6Signal transducer and activator of transcription. (844 aa)
STAT2Signal transducer and activator of transcription. (854 aa)
IL23AInterleukin-23 subunit alpha. (209 aa)
IRF9Interferon regulatory factor 9 isoform X1. (484 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
CSF3RGranulocyte colony-stimulating factor receptor. (839 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1098 aa)
CREBBPCREB-binding protein isoform X1. (2433 aa)
IL9RInterleukin-9 receptor. (523 aa)
SOCS5Suppressor of cytokine signaling 5 isoform X1. (536 aa)
HRASGTPase HRas isoform X1. (189 aa)
LIFRLeukemia inhibitory factor receptor. (1097 aa)
OSMRoncostatin-M-specific receptor subunit beta. (968 aa)
IL7RInterleukin-7 receptor subunit alpha. (458 aa)
MCL1Induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1. (350 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
IL12RB1Interleukin-12 receptor subunit beta-1. (722 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
IL11Interleukin-11. (199 aa)
IL9Interleukin-9. (143 aa)
IFNB1Interferon beta. (182 aa)
LOC101374322Interferon alpha-1/2-like. (187 aa)
LOC101374610Interferon alpha-14-like. (182 aa)
LOC101379735Interferon beta-like. (174 aa)
LOC101371706Somatotropin isoform X1. (216 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
IL22Interleukin-22 isoform X2. (179 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
IFNAR2Interferon alpha/beta receptor 2. (517 aa)
IL10RBInterleukin-10 receptor subunit beta. (375 aa)
IFNAR1Interferon alpha/beta receptor 1. (560 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1333 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (292 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (132 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IL13Interleukin-13. (131 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (153 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (416 aa)
PIAS2E3 SUMO-protein ligase PIAS2 isoform X1. (621 aa)
GHRGrowth hormone receptor. (841 aa)
CNTFCiliary neurotrophic factor. (199 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
IL22RA2Interleukin-22 receptor subunit alpha-2. (231 aa)
IFNGR1Interferon gamma receptor 1. (466 aa)
IL20RAInterleukin-20 receptor subunit alpha. (502 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
CSF2RBCytokine receptor common subunit beta. (902 aa)
IL2RBInterleukin-2 receptor subunit beta. (550 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2559 aa)
IL15RAInterleukin-15 receptor subunit alpha. (266 aa)
IL13RA2Interleukin-13 receptor subunit alpha-2 isoform X1. (409 aa)
LOC101381320Interferon lambda-1-like. (190 aa)
IFNA5Interferon alpha-5. (183 aa)
LOC101377641Interferon alpha-1/2-like. (187 aa)
IFNEInterferon epsilon. (208 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
PDGFAPlatelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (211 aa)
IL20RBLOW QUALITY PROTEIN: interleukin-20 receptor subunit beta. (319 aa)
IL10RAInterleukin-10 receptor subunit alpha. (577 aa)
IL23RInterleukin-23 receptor. (629 aa)
IL12RB2Interleukin-12 receptor subunit beta-2 isoform X1. (862 aa)
STAM2Signal transducing adapter molecule 2 isoform X1. (524 aa)
LOC101367134GTPase HRas-like. (177 aa)
IL20Interleukin-20 isoform X1. (176 aa)
IL24Interleukin-24. (183 aa)
IL19Interleukin-19. (177 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
IL6STInterleukin-6 receptor subunit beta isoform X1. (918 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (175 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
IFNKInterferon kappa. (208 aa)
IL10Interleukin-10. (178 aa)
LOC101376217Induced myeloid leukemia cell differentiation protein Mcl-1 homolog. (197 aa)
PRLProlactin. (229 aa)
IFNL1LOW QUALITY PROTEIN: interferon lambda-1. (189 aa)
IFNLR1Interferon lambda receptor 1. (510 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
LOC101386269Cardiotrophin-2. (203 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (242 aa)
IL5RAInterleukin-5 receptor subunit alpha. (417 aa)
CSF2RAGranulocyte-macrophage colony-stimulating factor receptor subunit alpha. (455 aa)
LOC105757391Granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like. (407 aa)
IL3RALOW QUALITY PROTEIN: interleukin-3 receptor subunit alpha. (462 aa)
CRLF2Cytokine receptor-like factor 2. (370 aa)
LIFLeukemia inhibitory factor isoform X1. (204 aa)
SOCS2LOW QUALITY PROTEIN: suppressor of cytokine signaling 2. (287 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
LOC105757531Suppressor of cytokine signaling 6-like. (365 aa)
IL6RInterleukin-6 receptor subunit alpha. (479 aa)
IL13RA1Interleukin-13 receptor subunit alpha-1 isoform X1. (427 aa)
THPOLOW QUALITY PROTEIN: thrombopoietin. (276 aa)
LOC101374328Tyrosine-protein phosphatase non-receptor type 11-like. (581 aa)
FHL1Four and a half LIM domains protein 1 isoform X1. (339 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1210 aa)
LOC101382582LOW QUALITY PROTEIN: aldehyde oxidase 2-like. (1483 aa)
STAT5BSignal transducer and activator of transcription. (818 aa)
IL2RAInterleukin-2 receptor subunit alpha. (422 aa)
LOC101369776LOW QUALITY PROTEIN: aldehyde oxidase 4-like. (1335 aa)
LEPRLeptin receptor isoform X1. (1166 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
LOC101379383LOW QUALITY PROTEIN: interferon omega-2-like. (237 aa)
PIAS1E3 SUMO-protein ligase PIAS1 isoform X1. (655 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (630 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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