STRINGSTRING
PPP3CA PPP3CA PAK1 PAK1 LCP2 LCP2 PLCG2 PLCG2 TNFSF10 TNFSF10 PRF1 PRF1 RAC1 RAC1 GRB2 GRB2 MAP2K2 MAP2K2 SHC2 SHC2 SH3BP2 SH3BP2 TYROBP TYROBP HCST HCST SHC4 SHC4 ARAF ARAF MAPK3 MAPK3 ITGAL ITGAL PIK3CD PIK3CD PPP3R1 PPP3R1 PIK3CA PIK3CA PRKCB PRKCB ICAM1 ICAM1 SH2D1A SH2D1A ZAP70 ZAP70 MAPK1 MAPK1 PIK3R3 PIK3R3 LOC101370515 LOC101370515 LOC101383301 LOC101383301 SH2D1B SH2D1B HRAS HRAS RAC3 RAC3 PIK3R2 PIK3R2 LOC101383210 LOC101383210 NCR1 NCR1 VAV3 VAV3 IFNB1 IFNB1 LOC101374322 LOC101374322 LOC101374610 LOC101374610 LOC101379735 LOC101379735 ICAM2 ICAM2 IFNAR2 IFNAR2 IFNAR1 IFNAR1 LCK LCK FYN FYN BID BID FCER1G FCER1G SOS2 SOS2 CSF2 CSF2 PRKCG PRKCG SYK SYK SHC3 SHC3 SOS1 SOS1 IFNGR1 IFNGR1 PTPN11 PTPN11 ITGB2 ITGB2 RAC2 RAC2 VAV2 VAV2 PTK2B PTK2B FASLG FASLG KLRD1 KLRD1 IFNA5 IFNA5 LOC101377641 LOC101377641 LOC101370467 LOC101370467 NFATC1 NFATC1 PIK3CB PIK3CB PTPN6 PTPN6 PPP3R2 PPP3R2 MAP2K1 MAP2K1 NFATC2 NFATC2 TNF TNF LOC101367134 LOC101367134 PRKCA PRKCA PIK3R1 PIK3R1 IFNG IFNG LOC101366544 LOC101366544 VAV1 VAV1 RAF1 RAF1 LAT LAT NRAS NRAS PPP3CC PPP3CC LOC101363133 LOC101363133 SHC1 SHC1 LOC105757616 LOC105757616 PPP3CB PPP3CB LOC101374328 LOC101374328 CD244 CD244 CD48 CD48 CD247 CD247 FAS FAS PLCG1 PLCG1 KLRK1 KLRK1 CASP3 CASP3 BRAF BRAF NCR3 NCR3 NCR2 NCR2 LOC105758402 LOC105758402 LOC101376213 LOC101376213 LOC101367540 LOC101367540
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP3CASerine/threonine-protein phosphatase. (521 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (286 aa)
PRF1Perforin-1. (555 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (211 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
SHC2SHC-transforming protein 2. (586 aa)
SH3BP2LOW QUALITY PROTEIN: SH3 domain-binding protein 2. (601 aa)
TYROBPTYRO protein tyrosine kinase-binding protein isoform X1. (111 aa)
HCSTHematopoietic cell signal transducer. (79 aa)
SHC4SHC-transforming protein 4. (630 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ITGALIntegrin alpha-L; Belongs to the integrin alpha chain family. (1168 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PPP3R1Calcineurin subunit B type 1 isoform X1. (170 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ICAM1Intercellular adhesion molecule 1. (595 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (128 aa)
ZAP70Tyrosine-protein kinase ZAP-70; Belongs to the protein kinase superfamily. Tyr protein kinase family. (326 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
LOC101370515Granzyme B; Belongs to the peptidase S1 family. (249 aa)
LOC101383301Duodenase-1-like; Belongs to the peptidase S1 family. (252 aa)
SH2D1BSH2 domain-containing protein 1B. (143 aa)
HRASGTPase HRas isoform X1. (189 aa)
RAC3Ras-related C3 botulinum toxin substrate 3. (192 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
LOC101383210Killer cell immunoglobulin-like receptor 3DL3 isoform X1. (436 aa)
NCR1Natural cytotoxicity triggering receptor 1 isoform X1. (307 aa)
VAV3Guanine nucleotide exchange factor VAV3 isoform X1. (875 aa)
IFNB1Interferon beta. (182 aa)
LOC101374322Interferon alpha-1/2-like. (187 aa)
LOC101374610Interferon alpha-14-like. (182 aa)
LOC101379735Interferon beta-like. (174 aa)
ICAM2Intercellular adhesion molecule 2. (308 aa)
IFNAR2Interferon alpha/beta receptor 2. (517 aa)
IFNAR1Interferon alpha/beta receptor 1. (560 aa)
LCKTyrosine-protein kinase. (509 aa)
FYNTyrosine-protein kinase. (537 aa)
BIDBH3-interacting domain death agonist. (99 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (86 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1333 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (153 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
SYKTyrosine-protein kinase. (635 aa)
SHC3SHC-transforming protein 3. (587 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
IFNGR1Interferon gamma receptor 1. (466 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
ITGB2Integrin beta. (768 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (878 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
FASLGTumor necrosis factor ligand superfamily member 6 isoform X1; Belongs to the tumor necrosis factor family. (277 aa)
KLRD1Natural killer cells antigen CD94. (153 aa)
IFNA5Interferon alpha-5. (183 aa)
LOC101377641Interferon alpha-1/2-like. (187 aa)
LOC101370467Uncharacterized protein LOC101370467. (276 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (823 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
PPP3R2Calcineurin subunit B type 2. (170 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (920 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC101367134GTPase HRas-like. (177 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
LOC101366544LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like. (145 aa)
VAV1Proto-oncogene vav isoform X1. (864 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
LATLinker for activation of T-cells family member 1. (227 aa)
NRASGTPase NRas. (189 aa)
PPP3CCSerine/threonine-protein phosphatase. (534 aa)
LOC101363133Low affinity immunoglobulin gamma Fc region receptor III-B-like isoform X1. (249 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
LOC105757616NKG2D ligand 1-like. (249 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
LOC101374328Tyrosine-protein phosphatase non-receptor type 11-like. (581 aa)
CD244Natural killer cell receptor 2B4. (383 aa)
CD48CD48 antigen. (242 aa)
CD247T-cell surface glycoprotein CD3 zeta chain. (185 aa)
FASTumor necrosis factor receptor superfamily member 6. (319 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
KLRK1NKG2-D type II integral membrane protein isoform X1. (204 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (302 aa)
BRAFSerine/threonine-protein kinase B-raf. (772 aa)
NCR3Natural cytotoxicity triggering receptor 3. (179 aa)
NCR2Natural cytotoxicity triggering receptor 2. (374 aa)
LOC105758402LOW QUALITY PROTEIN: NKG2-A/NKG2-B type II integral membrane protein-like. (190 aa)
LOC101376213NKG2-A/NKG2-B type II integral membrane protein-like. (230 aa)
LOC101367540NKG2-A/NKG2-B type II integral membrane protein-like. (229 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.