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PAK1 PAK1 INPPL1 INPPL1 GAB2 GAB2 PLCG2 PLCG2 ARPC4 ARPC4 PLD1 PLD1 CFL1 CFL1 RAC1 RAC1 ARPC1A ARPC1A ARPC1B ARPC1B WASF2 WASF2 ASAP3 ASAP3 PPAP2C PPAP2C SCIN SCIN AKT1 AKT1 ARPC3 ARPC3 INPP5D INPP5D AMPH AMPH AKT2 AKT2 WAS WAS MAPK3 MAPK3 PIP5K1B PIP5K1B PIK3CD PIK3CD RPS6KB1 RPS6KB1 MARCKS MARCKS PIK3CA PIK3CA PLD2 PLD2 PRKCB PRKCB LIMK1 LIMK1 NCF1 NCF1 CFL2 CFL2 LIMK2 LIMK2 PLA2G4E PLA2G4E PLA2G4F PLA2G4F PLA2G4D PLA2G4D AKT3 AKT3 MAPK1 MAPK1 CRKL CRKL PIK3R3 PIK3R3 VASP VASP ASAP2 ASAP2 ARPC2 ARPC2 PRKCE PRKCE CRK CRK LOC101381082 LOC101381082 PIK3R2 PIK3R2 VAV3 VAV3 MARCKSL1 MARCKSL1 WASF1 WASF1 ARF6 ARF6 BIN1 BIN1 MYO10 MYO10 PRKCG PRKCG ASAP1 ASAP1 SYK SYK RAC2 RAC2 VAV2 VAV2 GSN GSN CDC42 CDC42 LOC101370467 LOC101370467 PIK3CB PIK3CB LYN LYN MAP2K1 MAP2K1 PPAP2B PPAP2B WASF3 WASF3 PRKCA PRKCA PIK3R1 PIK3R1 PPAP2A PPAP2A ARPC5L ARPC5L LOC101366544 LOC101366544 SPHK1 SPHK1 PIP5K1C PIP5K1C VAV1 VAV1 RAF1 RAF1 ARPC5 ARPC5 LAT LAT LOC101365594 LOC101365594 DNM2 DNM2 PLA2G4B PLA2G4B LOC101366585 LOC101366585 LOC101363133 LOC101363133 PIP5K1A PIP5K1A DOCK1 DOCK1 PLA2G4A PLA2G4A HCK HCK PLA2G6 PLA2G6 PLCG1 PLCG1 PRKCD PRKCD SPHK2 SPHK2 PTPRC PTPRC RPS6KB2 RPS6KB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAK1Non-specific serine/threonine protein kinase. (544 aa)
INPPL1Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2. (1264 aa)
GAB2GRB2-associated-binding protein 2. (677 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (186 aa)
PLD1Phospholipase. (1074 aa)
CFL1Cofilin-1 isoform X1; Belongs to the actin-binding proteins ADF family. (219 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (211 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
ARPC1BActin-related protein 2/3 complex subunit 1B. (344 aa)
WASF2wiskott-Aldrich syndrome protein family member 2. (498 aa)
ASAP3LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3. (902 aa)
PPAP2CLipid phosphate phosphohydrolase 2. (288 aa)
SCINAdseverin. (715 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1188 aa)
AMPHAmphiphysin isoform X1. (686 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
WASwiskott-Aldrich syndrome protein. (501 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1. (540 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
MARCKSMyristoylated alanine-rich C-kinase substrate. (333 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PLD2Phospholipase. (933 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
LIMK1LIM domain kinase 1 isoform X1. (647 aa)
NCF1Neutrophil cytosol factor 1. (501 aa)
CFL2Cofilin-2 isoform X1; Belongs to the actin-binding proteins ADF family. (166 aa)
LIMK2LIM domain kinase 2 isoform X1. (638 aa)
PLA2G4EPhospholipase A2. (864 aa)
PLA2G4FPhospholipase A2. (875 aa)
PLA2G4DPhospholipase A2. (817 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CRKLCrk-like protein. (303 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
VASPVasodilator-stimulated phosphoprotein isoform X1; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (381 aa)
ASAP2arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1. (1003 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
LOC101381082High affinity immunoglobulin gamma Fc receptor I. (350 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
VAV3Guanine nucleotide exchange factor VAV3 isoform X1. (875 aa)
MARCKSL1MARCKS-related protein. (199 aa)
WASF1wiskott-Aldrich syndrome protein family member 1 isoform X1. (559 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
BIN1Myc box-dependent-interacting protein 1 isoform X1. (594 aa)
MYO10Unconventional myosin-X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2048 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ASAP1arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1. (1128 aa)
SYKTyrosine-protein kinase. (635 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (878 aa)
GSNGelsolin isoform X1. (782 aa)
CDC42Cell division control protein 42 homolog isoform X1. (191 aa)
LOC101370467Uncharacterized protein LOC101370467. (276 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
LYNTyrosine-protein kinase. (512 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
PPAP2BLipid phosphate phosphohydrolase 3. (312 aa)
WASF3wiskott-Aldrich syndrome protein family member 3. (467 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
PPAP2ALipid phosphate phosphohydrolase 1 isoform X1. (286 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (243 aa)
LOC101366544LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like. (145 aa)
SPHK1Sphingosine kinase 1 isoform X1. (487 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1. (661 aa)
VAV1Proto-oncogene vav isoform X1. (864 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (154 aa)
LATLinker for activation of T-cells family member 1. (227 aa)
LOC101365594Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (167 aa)
DNM2Dynamin-2 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (881 aa)
PLA2G4BPhospholipase A2. (782 aa)
LOC101366585Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
LOC101363133Low affinity immunoglobulin gamma Fc region receptor III-B-like isoform X1. (249 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1. (582 aa)
DOCK1Dedicator of cytokinesis protein 1 isoform X1; Belongs to the DOCK family. (1889 aa)
PLA2G4APhospholipase A2. (749 aa)
HCKTyrosine-protein kinase. (502 aa)
PLA2G685/88 kDa calcium-independent phospholipase A2. (836 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
SPHK2Sphingosine kinase 2 isoform X1. (659 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C. (1302 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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