STRINGSTRING
PLCG2 PLCG2 LOC101364731 LOC101364731 ITGA4 ITGA4 RASSF5 RASSF5 MYL9 MYL9 CLDN11 CLDN11 CDH5 CDH5 GNAI1 GNAI1 SIPA1 SIPA1 ACTB ACTB RAC1 RAC1 MMP2 MMP2 MYL2 MYL2 RHOH RHOH TXK TXK MYL5 MYL5 ACTN4 ACTN4 PXN PXN NCF2 NCF2 MYLPF MYLPF ITGAL ITGAL PIK3CD PIK3CD PIK3CA PIK3CA CLDN7 CLDN7 PRKCB PRKCB ICAM1 ICAM1 CLDN3 CLDN3 CLDN4 CLDN4 CLDN15 CLDN15 MYL10 MYL10 RHOA RHOA NCF1 NCF1 GNAI2 GNAI2 LOC101379802 LOC101379802 ARHGAP5 ARHGAP5 PIK3R3 PIK3R3 ARHGAP35 ARHGAP35 VASP VASP RAP1A RAP1A VCAM1 VCAM1 ITGB1 ITGB1 ROCK2 ROCK2 CLDN9 CLDN9 CLDN6 CLDN6 OCLN OCLN CXCR4 CXCR4 PIK3R2 PIK3R2 ITK ITK MMP9 MMP9 VAV3 VAV3 PTK2 PTK2 PECAM1 PECAM1 RAP1B RAP1B CLDN8 CLDN8 CLDN17 CLDN17 CLDN19 CLDN19 VCL VCL CD99L2 CD99L2 GNAI3 GNAI3 RAPGEF4 RAPGEF4 F11R F11R CLDN10 CLDN10 LOC101382469 LOC101382469 CTNND1 CTNND1 PRKCG PRKCG MAPK11 MAPK11 MAPK12 MAPK12 MAPK13 MAPK13 MAPK14 MAPK14 PTPN11 PTPN11 ITGB2 ITGB2 RAC2 RAC2 NCF4 NCF4 VAV2 VAV2 PTK2B PTK2B CDC42 CDC42 LOC101374641 LOC101374641 LOC101375321 LOC101375321 CLDN1 CLDN1 CLDN16 CLDN16 BCAR1 BCAR1 CLDN23 CLDN23 PIK3CB PIK3CB ESAM ESAM MYL7 MYL7 CLDN2 CLDN2 CLDN24 CLDN24 PRKCA PRKCA PIK3R1 PIK3R1 JAM3 JAM3 CLDN25 CLDN25 CLDN20 CLDN20 EZR EZR CXCL12 CXCL12 CLDN14 CLDN14 MSN MSN CTNNB1 CTNNB1 CLDN5 CLDN5 LOC101366544 LOC101366544 VAV1 VAV1 RAPGEF3 RAPGEF3 ACTN1 ACTN1 CTNNA1 CTNNA1 CD99 CD99 LOC105757464 LOC105757464 MLLT4 MLLT4 LOC101371803 LOC101371803 LOC101374328 LOC101374328 ROCK1 ROCK1 CTNNA2 CTNNA2 PLCG1 PLCG1 THY1 THY1 JAM2 JAM2 ITGAM ITGAM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
LOC101364731Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
ITGA4Integrin alpha-4; Belongs to the integrin alpha chain family. (1033 aa)
RASSF5Ras association domain-containing protein 5 isoform X1. (416 aa)
MYL9Myosin regulatory light polypeptide 9 isoform X1. (172 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
CDH5Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (792 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (359 aa)
SIPA1Signal-induced proliferation-associated protein 1 isoform X1. (1043 aa)
ACTBActin, cytoplasmic 1 isoform X2. (375 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (211 aa)
MMP272 kDa type IV collagenase. (661 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1. (166 aa)
RHOHRho-related GTP-binding protein RhoH. (191 aa)
TXKTyrosine-protein kinase. (527 aa)
MYL5Myosin light chain 5. (132 aa)
ACTN4Alpha-actinin-4 isoform X1. (933 aa)
PXNPaxillin; Belongs to the paxillin family. (557 aa)
NCF2Neutrophil cytosol factor 2 isoform X1. (526 aa)
MYLPFMyosin regulatory light chain 2, skeletal muscle isoform isoform X1. (185 aa)
ITGALIntegrin alpha-L; Belongs to the integrin alpha chain family. (1168 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CLDN7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ICAM1Intercellular adhesion molecule 1. (595 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (232 aa)
MYL10Myosin regulatory light chain 10. (167 aa)
RHOATransforming protein RhoA isoform X1. (193 aa)
NCF1Neutrophil cytosol factor 1. (501 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform X1. (436 aa)
LOC101379802Cytochrome b-245 heavy chain. (570 aa)
ARHGAP5Rho GTPase-activating protein 5 isoform X1. (1503 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
ARHGAP35Rho GTPase-activating protein 35. (1500 aa)
VASPVasodilator-stimulated phosphoprotein isoform X1; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (381 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
VCAM1Vascular cell adhesion protein 1 isoform X1. (735 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
CLDN9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
CLDN6Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (221 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (521 aa)
CXCR4C-X-C chemokine receptor type 4 isoform X1; Belongs to the G-protein coupled receptor 1 family. (353 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
ITKTyrosine-protein kinase. (620 aa)
MMP9Matrix metalloproteinase-9. (704 aa)
VAV3Guanine nucleotide exchange factor VAV3 isoform X1. (875 aa)
PTK2Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1052 aa)
PECAM1Platelet endothelial cell adhesion molecule. (741 aa)
RAP1BRas-related protein Rap-1b isoform X1. (184 aa)
CLDN8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
CLDN17Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
VCLVinculin isoform X1. (1134 aa)
CD99L2CD99 antigen-like protein 2. (216 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4 isoform X1. (1011 aa)
F11RJunctional adhesion molecule A. (298 aa)
CLDN10Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (231 aa)
LOC101382469Claudin-9-like. (214 aa)
CTNND1Catenin delta-1 isoform X1. (1022 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
ITGB2Integrin beta. (768 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
NCF4Neutrophil cytosol factor 4. (339 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (878 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
CDC42Cell division control protein 42 homolog isoform X1. (191 aa)
LOC101374641Myosin regulatory light polypeptide 9 isoform X1. (178 aa)
LOC101375321Myosin regulatory light chain 12B isoform X1. (172 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (237 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1 isoform X2. (865 aa)
CLDN23Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (291 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
ESAMEndothelial cell-selective adhesion molecule. (393 aa)
MYL7Myosin regulatory light chain 2, atrial isoform isoform X1. (195 aa)
CLDN2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
CLDN24Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
JAM3Junctional adhesion molecule C. (310 aa)
CLDN25Putative claudin-25. (228 aa)
CLDN20Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
EZREzrin isoform X1. (584 aa)
CXCL12Stromal cell-derived factor 1 isoform X1; Belongs to the intercrine alpha (chemokine CxC) family. (184 aa)
CLDN14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (237 aa)
MSNMoesin. (577 aa)
CTNNB1Catenin beta-1 isoform X1. (781 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (310 aa)
LOC101366544LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like. (145 aa)
VAV1Proto-oncogene vav isoform X1. (864 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3 isoform X1. (923 aa)
ACTN1Alpha-actinin-1 isoform X1. (914 aa)
CTNNA1Catenin alpha-1 isoform X1. (929 aa)
CD99CD99 antigen. (191 aa)
LOC105757464Claudin-9-like. (243 aa)
MLLT4Afadin isoform X2. (1780 aa)
LOC101371803Claudin-6-like. (200 aa)
LOC101374328Tyrosine-protein phosphatase non-receptor type 11-like. (581 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
CTNNA2Catenin alpha-2 isoform X1. (953 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
THY1Thy-1 membrane glycoprotein. (161 aa)
JAM2Junctional adhesion molecule B isoform X1. (301 aa)
ITGAMIntegrin alpha-M; Belongs to the integrin alpha chain family. (1114 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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