STRINGSTRING
GABRB2 GABRB2 DUSP1 DUSP1 CACNA1S CACNA1S GNAI1 GNAI1 PLCB3 PLCB3 GNGT1 GNGT1 HTR1D HTR1D KCNJ3 KCNJ3 LOC101365057 LOC101365057 GNGT2 GNGT2 GNG7 GNG7 HTR2B HTR2B GABRB1 GABRB1 GNB5 GNB5 ARAF ARAF CACNA1F CACNA1F GNAQ GNAQ GNG10 GNG10 HTR6 HTR6 MAPK3 MAPK3 TRPC1 TRPC1 GNB4 GNB4 ALOX15B ALOX15B ALOX12B ALOX12B ALOX12 ALOX12 ALOX15 ALOX15 PRKCB PRKCB CACNA1A CACNA1A PRKACA PRKACA LOC101368814 LOC101368814 GNB2 GNB2 GNAI2 GNAI2 SLC6A4 SLC6A4 LOC101379027 LOC101379027 PLA2G4E PLA2G4E PLA2G4F PLA2G4F PLA2G4D PLA2G4D PLCB2 PLCB2 MAPK1 MAPK1 GNG8 GNG8 HTR1A HTR1A HTR4 HTR4 GNG13 GNG13 HTR5A HTR5A HRAS HRAS KCND2 KCND2 PTGS2 PTGS2 TPH2 TPH2 LOC101381387 LOC101381387 LOC101364710 LOC101364710 CACNA1C CACNA1C GNAI3 GNAI3 GNB1 GNB1 KCNJ9 KCNJ9 GNG2 GNG2 ALOX5 ALOX5 PRKCG PRKCG LOC101382939 LOC101382939 MAOA MAOA MAOB MAOB CACNA1D CACNA1D PTGS1 PTGS1 HTR1E HTR1E HTR2C HTR2C KCNJ5 KCNJ5 HTR2A HTR2A TPH1 TPH1 LOC101365655 LOC101365655 LOC101379970 LOC101379970 APP APP PRKACB PRKACB GNG5 GNG5 HTR1F HTR1F GNG3 GNG3 GNG4 GNG4 SLC18A1 SLC18A1 GNAS GNAS LOC105757053 LOC105757053 GNB3 GNB3 KCNJ6 KCNJ6 GABRB3 GABRB3 MAP2K1 MAP2K1 PLCB1 PLCB1 DDC DDC GNG12 GNG12 LOC101367134 LOC101367134 PRKCA PRKCA ITPR2 ITPR2 LOC101384881 LOC101384881 HTR3A HTR3A KCNN2 KCNN2 LOC101383285 LOC101383285 LOC101377489 LOC101377489 SLC18A2 SLC18A2 HTR1B HTR1B GNG11 GNG11 RAF1 RAF1 RAPGEF3 RAPGEF3 ADCY5 ADCY5 LOC101372264 LOC101372264 LOC101379891 LOC101379891 ITPR1 ITPR1 PLA2G4B PLA2G4B NRAS NRAS PLA2G4A PLA2G4A LOC101364414 LOC101364414 LOC101364118 LOC101364118 ITPR3 ITPR3 LOC105758129 LOC105758129 CASP3 CASP3 BRAF BRAF PLCB4 PLCB4 HTR3B HTR3B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GABRB2Gamma-aminobutyric acid receptor subunit beta-2 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (512 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (359 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (94 aa)
HTR1D5-hydroxytryptamine receptor 1D. (377 aa)
KCNJ3G protein-activated inward rectifier potassium channel 1 isoform X1. (501 aa)
LOC101365057Cytochrome P450 2C23-like; Belongs to the cytochrome P450 family. (496 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
GABRB1Gamma-aminobutyric acid receptor subunit beta-1 isoform X2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (475 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5 isoform X1. (395 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1983 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
HTR65-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family. (440 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
TRPC1Short transient receptor potential channel 1 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
ALOX15BArachidonate 15-lipoxygenase B isoform X1. (677 aa)
ALOX12BArachidonate 12-lipoxygenase, 12R-type. (699 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S-type. (663 aa)
ALOX15Arachidonate 15-lipoxygenase. (663 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2501 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
LOC101368814Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1. (340 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform X1. (436 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (631 aa)
LOC101379027Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PLA2G4EPhospholipase A2. (864 aa)
PLA2G4FPhospholipase A2. (875 aa)
PLA2G4DPhospholipase A2. (817 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
HTR1A5-hydroxytryptamine receptor 1A. (422 aa)
HTR45-hydroxytryptamine receptor 4 isoform X1; Belongs to the G-protein coupled receptor 1 family. (388 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
HTR5A5-hydroxytryptamine receptor 5A. (358 aa)
HRASGTPase HRas isoform X1. (189 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (629 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
TPH2Tryptophan 5-hydroxylase 2 isoform X1. (497 aa)
LOC101381387LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3E; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (455 aa)
LOC1013647105-hydroxytryptamine receptor 3C; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2190 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1. (340 aa)
KCNJ9G protein-activated inward rectifier potassium channel 3. (392 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
ALOX5Arachidonate 5-lipoxygenase isoform X1. (674 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
LOC101382939Cytochrome P450 2J2; Belongs to the cytochrome P450 family. (502 aa)
MAOAAmine oxidase. (527 aa)
MAOBAmine oxidase. (520 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
PTGS1Prostaglandin G/H synthase 1 isoform X1. (632 aa)
HTR1E5-hydroxytryptamine receptor 1E. (365 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
KCNJ5G protein-activated inward rectifier potassium channel 4. (413 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
TPH1Tryptophan 5-hydroxylase 1. (444 aa)
LOC101365655Cytochrome P450 2C41 isoform X1; Belongs to the cytochrome P450 family. (490 aa)
LOC101379970Cytochrome P450 4X1; Belongs to the cytochrome P450 family. (506 aa)
APPAmyloid beta A4 protein isoform X1. (770 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (358 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
HTR1F5-hydroxytryptamine receptor 1F. (366 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
SLC18A1Chromaffin granule amine transporter isoform X1. (525 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1015 aa)
LOC105757053Neuroendocrine secretory protein 55. (246 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
KCNJ6G protein-activated inward rectifier potassium channel 2. (423 aa)
GABRB3Gamma-aminobutyric acid receptor subunit beta-3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (388 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
DDCaromatic-L-amino-acid decarboxylase. (480 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
LOC101367134GTPase HRas-like. (177 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2639 aa)
LOC1013848815-hydroxytryptamine receptor 7. (235 aa)
HTR3A5-hydroxytryptamine receptor 3A isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (483 aa)
KCNN2Small conductance calcium-activated potassium channel protein 2 isoform X1. (841 aa)
LOC101383285Cytochrome P450 2C21 isoform X2; Belongs to the cytochrome P450 family. (517 aa)
LOC1013774895-hydroxytryptamine receptor 5B. (374 aa)
SLC18A2Synaptic vesicular amine transporter. (516 aa)
HTR1B5-hydroxytryptamine receptor 1B. (389 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3 isoform X1. (923 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
LOC101372264LOW QUALITY PROTEIN: cytochrome P450 2D15. (491 aa)
LOC101379891LOW QUALITY PROTEIN: arachidonate 12-lipoxygenase, epidermal-type-like. (662 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2758 aa)
PLA2G4BPhospholipase A2. (782 aa)
NRASGTPase NRas. (189 aa)
PLA2G4APhospholipase A2. (749 aa)
LOC101364414LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3C-like; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (474 aa)
LOC101364118LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3C-like; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3 isoform X1. (2674 aa)
LOC105758129Voltage-dependent N-type calcium channel subunit alpha-1B-like. (873 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (302 aa)
BRAFSerine/threonine-protein kinase B-raf. (772 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
HTR3B5-hydroxytryptamine receptor 3B; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (483 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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