STRINGSTRING
MAPK10 MAPK10 PPP3CA PPP3CA ARRB1 ARRB1 CREB3 CREB3 GNAI1 GNAI1 PPP1CA PPP1CA PPP2R5B PPP2R5B PLCB3 PLCB3 GNGT1 GNGT1 GRIA2 GRIA2 CALM1 CALM1 ARNTL ARNTL KCNJ3 KCNJ3 PPP1CB PPP1CB GNGT2 GNGT2 PPP1R1B PPP1R1B GNG7 GNG7 AKT1 AKT1 PPP1CC PPP1CC AKT2 AKT2 GNB5 GNB5 GNAQ GNAQ SCN1A SCN1A GNG10 GNG10 ATF4 ATF4 GNB4 GNB4 ARRB2 ARRB2 PRKCB PRKCB CACNA1A CACNA1A PRKACA PRKACA LOC101368814 LOC101368814 GNB2 GNB2 GNAI2 GNAI2 FOS FOS CREB3L1 CREB3L1 PPP2R3C PPP2R3C LOC101379027 LOC101379027 PPP2R3B PPP2R3B GRIA3 GRIA3 PLCB2 PLCB2 AKT3 AKT3 CALM3 CALM3 GNG8 GNG8 LOC101373722 LOC101373722 GRIN2A GRIN2A LOC101372085 LOC101372085 KIF5A KIF5A KIF5B KIF5B CAMK2A CAMK2A CREB3L4 CREB3L4 GNG13 GNG13 CALM2 CALM2 GSK3B GSK3B DRD4 DRD4 TH TH CREB1 CREB1 PPP2CA PPP2CA CAMK2D CAMK2D CACNA1C CACNA1C GNAI3 GNAI3 GNB1 GNB1 CALML6 CALML6 KCNJ9 KCNJ9 GNG2 GNG2 GSK3A GSK3A PPP2CB PPP2CB GNAL GNAL PRKCG PRKCG MAPK11 MAPK11 MAPK12 MAPK12 GRIA1 GRIA1 MAPK13 MAPK13 MAPK14 MAPK14 GRIN2B GRIN2B MAOA MAOA MAOB MAOB CACNA1D CACNA1D SLC6A3 SLC6A3 CALML3 CALML3 KCNJ5 KCNJ5 CALML4 CALML4 MAPK9 MAPK9 GRIA4 GRIA4 PPP2R2A PPP2R2A PRKACB PRKACB GNG5 GNG5 GNG3 GNG3 GNG4 GNG4 SLC18A1 SLC18A1 GNAS GNAS LOC105757053 LOC105757053 CAMK2B CAMK2B GNB3 GNB3 CREB5 CREB5 KCNJ6 KCNJ6 PPP2R5A PPP2R5A DRD1 DRD1 PPP2R2B PPP2R2B DRD3 DRD3 COMT COMT PLCB1 PLCB1 DDC DDC GNG12 GNG12 ATF6B ATF6B PRKCA PRKCA ITPR2 ITPR2 DRD5 DRD5 DRD2 DRD2 CREB3L2 CREB3L2 PPP2R2C PPP2R2C PPP2R3A PPP2R3A SLC18A2 SLC18A2 GNG11 GNG11 TOMT TOMT CALY CALY PPP2R5C PPP2R5C ADCY5 ADCY5 CLOCK CLOCK ITPR1 ITPR1 KIF5C KIF5C PPP3CC PPP3CC PPP2R2D PPP2R2D LOC101386691 LOC101386691 PPP3CB PPP3CB PPP2R5D PPP2R5D MAPK8 MAPK8 ITPR3 ITPR3 ATF2 ATF2 PPP2R5E PPP2R5E CALML5 CALML5 LOC105758129 LOC105758129 PPP2R1B PPP2R1B PLCB4 PLCB4 PPP2R1A PPP2R1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK10Mitogen-activated protein kinase. (464 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ARRB1Beta-arrestin-1 isoform X1. (422 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (352 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (359 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (94 aa)
GRIA2Glutamate receptor 2 isoform X1. (940 aa)
CALM1Calmodulin isoform X1; Belongs to the calmodulin family. (155 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X1. (626 aa)
KCNJ3G protein-activated inward rectifier potassium channel 1 isoform X1. (501 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
PPP1R1BProtein phosphatase 1 regulatory subunit 1B. (206 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5 isoform X1. (395 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2009 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
ARRB2Beta-arrestin-2 isoform X1. (420 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2501 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
LOC101368814Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1. (340 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform X1. (436 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
PPP2R3CSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1. (453 aa)
LOC101379027Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PPP2R3BSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta. (578 aa)
GRIA3Glutamate receptor 3 isoform X2. (894 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CALM3Calmodulin isoform X2; Belongs to the calmodulin family. (149 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
LOC101373722Calmodulin-alpha-like; Belongs to the calmodulin family. (149 aa)
GRIN2AGlutamate receptor ionotropic, NMDA 2A. (1464 aa)
LOC101372085calmodulin-A-like; Belongs to the calmodulin family. (271 aa)
KIF5AKinesin heavy chain isoform 5A isoform X2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1032 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (963 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (393 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
CALM2Calmodulin isoform X1; Belongs to the calmodulin family. (155 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
DRD4D(4) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (362 aa)
THTyrosine 3-monooxygenase. (495 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta. (477 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2190 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1. (340 aa)
CALML6Calmodulin-like protein 6. (167 aa)
KCNJ9G protein-activated inward rectifier potassium channel 3. (392 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
GNALGuanine nucleotide-binding protein G(Olf) subunit alpha isoform X1. (461 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
GRIA1LOW QUALITY PROTEIN: glutamate receptor 1. (906 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
GRIN2BGlutamate receptor ionotropic, NMDA 2B. (1484 aa)
MAOAAmine oxidase. (527 aa)
MAOBAmine oxidase. (520 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (617 aa)
CALML3Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
KCNJ5G protein-activated inward rectifier potassium channel 4. (413 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like protein 4. (197 aa)
MAPK9Mitogen-activated protein kinase. (427 aa)
GRIA4Glutamate receptor 4 isoform X2. (902 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (457 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (358 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
SLC18A1Chromaffin granule amine transporter isoform X1. (525 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1015 aa)
LOC105757053Neuroendocrine secretory protein 55. (246 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta isoform X1. (542 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (369 aa)
KCNJ6G protein-activated inward rectifier potassium channel 2. (423 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
DRD1D(1A) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (446 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
DRD3D(3) dopamine receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (400 aa)
COMTCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (270 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
DDCaromatic-L-amino-acid decarboxylase. (480 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta isoform X2. (711 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2639 aa)
DRD5D(1B) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (474 aa)
DRD2D(2) dopamine receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (443 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (519 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
PPP2R3ASerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1. (1152 aa)
SLC18A2Synaptic vesicular amine transporter. (516 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
TOMTTransmembrane O-methyltransferase isoform X1. (347 aa)
CALYNeuron-specific vesicular protein calcyon. (226 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (558 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
CLOCKCircadian locomoter output cycles protein kaput isoform X1. (845 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2758 aa)
KIF5CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (957 aa)
PPP3CCSerine/threonine-protein phosphatase. (534 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (424 aa)
LOC101386691Calmodulin-like; Belongs to the calmodulin family. (176 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (678 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3 isoform X1. (2674 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
CALML5Calmodulin-like protein 5. (149 aa)
LOC105758129Voltage-dependent N-type calcium channel subunit alpha-1B-like. (873 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1. (694 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1. (590 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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