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MAPK10 MAPK10 CACNA1S CACNA1S GNRHR GNRHR PLD1 PLD1 PLCB3 PLCB3 GRB2 GRB2 CALM1 CALM1 ADCY3 ADCY3 MAP2K2 MAP2K2 MMP2 MMP2 ELK1 ELK1 CACNA1F CACNA1F GNAQ GNAQ MAPK3 MAPK3 ATF4 ATF4 HBEGF HBEGF EGR1 EGR1 PLD2 PLD2 PRKCB PRKCB PRKACA PRKACA PLA2G4E PLA2G4E PLA2G4F PLA2G4F PLA2G4D PLA2G4D PLCB2 PLCB2 MAPK1 MAPK1 CALM3 CALM3 MAP3K4 MAP3K4 LOC101373722 LOC101373722 LOC101372085 LOC101372085 MMP14 MMP14 CAMK2A CAMK2A ADCY9 ADCY9 CALM2 CALM2 HRAS HRAS MAP2K3 MAP2K3 MAP2K6 MAP2K6 MAP3K3 MAP3K3 CAMK2D CAMK2D CACNA1C CACNA1C CALML6 CALML6 SOS2 SOS2 MAP3K2 MAP3K2 MAP3K1 MAP3K1 MAPK11 MAPK11 MAPK12 MAPK12 MAPK13 MAPK13 MAPK14 MAPK14 ADCY8 ADCY8 SOS1 SOS1 CACNA1D CACNA1D PTK2B PTK2B CDC42 CDC42 CGA CGA CALML3 CALML3 MAP2K7 MAP2K7 CALML4 CALML4 MAPK9 MAPK9 LOC101369871 LOC101369871 PRKACB PRKACB GNAS GNAS LOC105757053 LOC105757053 CAMK2B CAMK2B GNRH1 GNRH1 MAP2K1 MAP2K1 PLCB1 PLCB1 JUN JUN LOC101369994 LOC101369994 LOC101367134 LOC101367134 ADCY2 ADCY2 PRKCA PRKCA ITPR2 ITPR2 GNA11 GNA11 RAF1 RAF1 ADCY5 ADCY5 GNRH2 GNRH2 ITPR1 ITPR1 LOC101379215 LOC101379215 PLA2G4B PLA2G4B NRAS NRAS ADCY6 ADCY6 ADCY4 ADCY4 MAPK7 MAPK7 LOC101386691 LOC101386691 PLA2G4A PLA2G4A SRC SRC ADCY7 ADCY7 MAPK8 MAPK8 ITPR3 ITPR3 ADCY1 ADCY1 CALML5 CALML5 PRKCD PRKCD PLCB4 PLCB4 MAP2K4 MAP2K4 EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK10Mitogen-activated protein kinase. (464 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
GNRHRGonadotropin-releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (327 aa)
PLD1Phospholipase. (1074 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
CALM1Calmodulin isoform X1; Belongs to the calmodulin family. (155 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
MMP272 kDa type IV collagenase. (661 aa)
ELK1ETS domain-containing protein Elk-1. (435 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1983 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
PLD2Phospholipase. (933 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
PLA2G4EPhospholipase A2. (864 aa)
PLA2G4FPhospholipase A2. (875 aa)
PLA2G4DPhospholipase A2. (817 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
CALM3Calmodulin isoform X2; Belongs to the calmodulin family. (149 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4 isoform X1. (1602 aa)
LOC101373722Calmodulin-alpha-like; Belongs to the calmodulin family. (149 aa)
LOC101372085calmodulin-A-like; Belongs to the calmodulin family. (271 aa)
MMP14Matrix metalloproteinase-14 isoform X1. (582 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
CALM2Calmodulin isoform X1; Belongs to the calmodulin family. (155 aa)
HRASGTPase HRas isoform X1. (189 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3 isoform X1. (657 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta. (477 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2190 aa)
CALML6Calmodulin-like protein 6. (167 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1333 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (620 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1508 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
CDC42Cell division control protein 42 homolog isoform X1. (191 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
CALML3Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (435 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like protein 4. (197 aa)
MAPK9Mitogen-activated protein kinase. (427 aa)
LOC101369871Follitropin subunit beta. (129 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (358 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1015 aa)
LOC105757053Neuroendocrine secretory protein 55. (246 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta isoform X1. (542 aa)
GNRH1Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (96 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
JUNTranscription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
LOC101369994Lutropin subunit beta. (141 aa)
LOC101367134GTPase HRas-like. (177 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2639 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (301 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
GNRH2Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (106 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2758 aa)
LOC101379215LOW QUALITY PROTEIN: gonadotropin-releasing hormone II receptor-like. (285 aa)
PLA2G4BPhospholipase A2. (782 aa)
NRASGTPase NRas. (189 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (806 aa)
LOC101386691Calmodulin-like; Belongs to the calmodulin family. (176 aa)
PLA2G4APhospholipase A2. (749 aa)
SRCTyrosine-protein kinase. (553 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3 isoform X1. (2674 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
CALML5Calmodulin-like protein 5. (149 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X1; Belongs to the protein kinase superfamily. (411 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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