STRINGSTRING
CREB3 CREB3 GABBR2 GABBR2 GNAI1 GNAI1 PLCB3 PLCB3 GPER1 GPER1 GRB2 GRB2 CALM1 CALM1 KCNJ3 KCNJ3 POMC POMC ADCY3 ADCY3 NCOA1 NCOA1 KRT40 KRT40 KRT12 KRT12 KRT27 KRT27 KRT26 KRT26 KRT28 KRT28 RARA RARA KRT23 KRT23 KRT25 KRT25 MAP2K2 MAP2K2 SHC2 SHC2 AKT1 AKT1 MMP2 MMP2 AKT2 AKT2 SHC4 SHC4 GNAQ GNAQ MAPK3 MAPK3 ATF4 ATF4 PIK3CD PIK3CD HBEGF HBEGF BCL2 BCL2 PIK3CA PIK3CA TGFA TGFA PRKACA PRKACA GNAI2 GNAI2 FOS FOS CREB3L1 CREB3L1 PLCB2 PLCB2 AKT3 AKT3 MAPK1 MAPK1 PIK3R3 PIK3R3 CALM3 CALM3 LOC101373722 LOC101373722 LOC101372085 LOC101372085 CREB3L4 CREB3L4 ADCY9 ADCY9 CALM2 CALM2 HRAS HRAS CTSD CTSD EBAG9 EBAG9 PIK3R2 PIK3R2 MMP9 MMP9 CREB1 CREB1 SP1 SP1 KRT18 KRT18 TFF1 TFF1 GNAI3 GNAI3 CALML6 CALML6 KCNJ9 KCNJ9 SOS2 SOS2 HSP90AB1 HSP90AB1 NCOA2 NCOA2 ESR2 ESR2 HSPA2 HSPA2 PGR PGR ADCY8 ADCY8 SHC3 SHC3 SOS1 SOS1 LOC101362260 LOC101362260 LOC101386619 LOC101386619 KRT32 KRT32 LOC101362565 LOC101362565 KRT19 KRT19 KRT35 KRT35 KRT14 KRT14 KRT15 KRT15 KRT17 KRT17 LOC101386909 LOC101386909 KRT13 KRT13 LOC101364721 LOC101364721 KRT36 KRT36 LOC101365026 LOC101365026 LOC101366235 LOC101366235 KRT9 KRT9 KRT16 KRT16 CALML3 CALML3 FKBP4 FKBP4 KCNJ5 KCNJ5 GABBR1 GABBR1 CALML4 CALML4 PIK3CB PIK3CB PRKACB PRKACB HSPA8 HSPA8 GNAS GNAS LOC105757053 LOC105757053 CREB5 CREB5 KCNJ6 KCNJ6 HSP90B1 HSP90B1 MAP2K1 MAP2K1 PLCB1 PLCB1 JUN JUN LOC101376406 LOC101376406 ATF6B ATF6B LOC101367134 LOC101367134 ADCY2 ADCY2 ITPR2 ITPR2 PIK3R1 PIK3R1 CREB3L2 CREB3L2 KRT24 KRT24 HSP90AA1 HSP90AA1 KRT20 KRT20 RAF1 RAF1 KRT39 KRT39 KRT10 KRT10 ADCY5 ADCY5 LOC101375744 LOC101375744 ITPR1 ITPR1 NRAS NRAS ADCY6 ADCY6 ADCY4 ADCY4 HSPA6 HSPA6 SHC1 SHC1 ESR1 ESR1 NCOA3 NCOA3 LOC101386691 LOC101386691 FKBP5 FKBP5 SRC SRC ADCY7 ADCY7 ITPR3 ITPR3 NOS3 NOS3 LOC101381301 LOC101381301 ATF2 ATF2 ADCY1 ADCY1 CALML5 CALML5 PRKCD PRKCD OPRM1 OPRM1 PLCB4 PLCB4 HSPA1L HSPA1L EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CREB3Cyclic AMP-responsive element-binding protein 3. (352 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (941 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (359 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
CALM1Calmodulin isoform X1; Belongs to the calmodulin family. (155 aa)
KCNJ3G protein-activated inward rectifier potassium channel 1 isoform X1. (501 aa)
POMCPro-opiomelanocortin. (258 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
KRT40Keratin, type I cytoskeletal 40; Belongs to the intermediate filament family. (431 aa)
KRT12Keratin, type I cytoskeletal 12 isoform X1; Belongs to the intermediate filament family. (496 aa)
KRT27Keratin, type I cytoskeletal 27; Belongs to the intermediate filament family. (450 aa)
KRT26Keratin, type I cytoskeletal 26; Belongs to the intermediate filament family. (464 aa)
KRT28Keratin, type I cytoskeletal 28; Belongs to the intermediate filament family. (464 aa)
RARARetinoic acid receptor alpha isoform X1. (462 aa)
KRT23Keratin, type I cytoskeletal 23; Belongs to the intermediate filament family. (420 aa)
KRT25Keratin, type I cytoskeletal 25; Belongs to the intermediate filament family. (450 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
SHC2SHC-transforming protein 2. (586 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MMP272 kDa type IV collagenase. (661 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SHC4SHC-transforming protein 4. (630 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
BCL2Apoptosis regulator Bcl-2. (235 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TGFAProtransforming growth factor alpha isoform X1. (160 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform X1. (436 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
CALM3Calmodulin isoform X2; Belongs to the calmodulin family. (149 aa)
LOC101373722Calmodulin-alpha-like; Belongs to the calmodulin family. (149 aa)
LOC101372085calmodulin-A-like; Belongs to the calmodulin family. (271 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (393 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
CALM2Calmodulin isoform X1; Belongs to the calmodulin family. (155 aa)
HRASGTPase HRas isoform X1. (189 aa)
CTSDCathepsin D isoform X1; Belongs to the peptidase A1 family. (410 aa)
EBAG9Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. (229 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
MMP9Matrix metalloproteinase-9. (704 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
SP1Transcription factor Sp1 isoform X1. (786 aa)
KRT18Keratin, type I cytoskeletal 18 isoform X1; Belongs to the intermediate filament family. (430 aa)
TFF1Trefoil factor 1. (88 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
CALML6Calmodulin-like protein 6. (167 aa)
KCNJ9G protein-activated inward rectifier potassium channel 3. (392 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1333 aa)
HSP90AB1Heat shock protein HSP 90-beta isoform X1. (720 aa)
NCOA2Nuclear receptor coactivator. (1464 aa)
ESR2Estrogen receptor beta isoform X1. (549 aa)
HSPA2Heat shock-related 70 kDa protein 2; Belongs to the heat shock protein 70 family. (638 aa)
PGRProgesterone receptor isoform X1. (930 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
SHC3SHC-transforming protein 3. (587 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
LOC101362260Keratin, type I cuticular Ha1; Belongs to the intermediate filament family. (409 aa)
LOC101386619Keratin, type I cuticular Ha3-I; Belongs to the intermediate filament family. (404 aa)
KRT32Keratin, type I cuticular Ha2; Belongs to the intermediate filament family. (447 aa)
LOC101362565Keratin, type I cuticular Ha8; Belongs to the intermediate filament family. (457 aa)
KRT19Keratin, type I cytoskeletal 19; Belongs to the intermediate filament family. (411 aa)
KRT35Keratin, type I cuticular Ha5; Belongs to the intermediate filament family. (455 aa)
KRT14Keratin, type I cytoskeletal 14; Belongs to the intermediate filament family. (526 aa)
KRT15Keratin, type I cytoskeletal 15; Belongs to the intermediate filament family. (466 aa)
KRT17Keratin, type I cytoskeletal 17; Belongs to the intermediate filament family. (437 aa)
LOC101386909Keratin, type I cuticular Ha3-II isoform X1; Belongs to the intermediate filament family. (407 aa)
KRT13Keratin, type I cytoskeletal 13; Belongs to the intermediate filament family. (447 aa)
LOC101364721Keratin, type I cuticular Ha1-like; Belongs to the intermediate filament family. (393 aa)
KRT36Keratin, type I cuticular Ha6; Belongs to the intermediate filament family. (467 aa)
LOC101365026Keratin, type I cuticular Ha8; Belongs to the intermediate filament family. (437 aa)
LOC101366235Keratin, type I cytoskeletal 42; Belongs to the intermediate filament family. (461 aa)
KRT9Keratin, type I cytoskeletal 9; Belongs to the intermediate filament family. (613 aa)
KRT16Keratin, type I cytoskeletal 16; Belongs to the intermediate filament family. (480 aa)
CALML3Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
FKBP4Peptidylprolyl isomerase. (459 aa)
KCNJ5G protein-activated inward rectifier potassium channel 4. (413 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1 isoform X1. (963 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like protein 4. (197 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (358 aa)
HSPA8Heat shock cognate 71 kDa protein isoform X1; Belongs to the heat shock protein 70 family. (654 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1015 aa)
LOC105757053Neuroendocrine secretory protein 55. (246 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (369 aa)
KCNJ6G protein-activated inward rectifier potassium channel 2. (423 aa)
HSP90B1Endoplasmin isoform X1. (804 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
JUNTranscription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
LOC101376406Heat shock 70 kDa protein 1; Belongs to the heat shock protein 70 family. (641 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta isoform X2. (711 aa)
LOC101367134GTPase HRas-like. (177 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2639 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (519 aa)
KRT24LOW QUALITY PROTEIN: keratin, type I cytoskeletal 24; Belongs to the intermediate filament family. (541 aa)
HSP90AA1LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha. (682 aa)
KRT20Keratin, type I cytoskeletal 20; Belongs to the intermediate filament family. (430 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
KRT39Keratin, type I cytoskeletal 39; Belongs to the intermediate filament family. (485 aa)
KRT10Keratin, type I cytoskeletal 10; Belongs to the intermediate filament family. (605 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
LOC101375744LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like; Belongs to the heat shock protein 70 family. (656 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2758 aa)
NRASGTPase NRas. (189 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
HSPA6LOW QUALITY PROTEIN: heat shock 70 kDa protein 6; Belongs to the heat shock protein 70 family. (688 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (597 aa)
NCOA3Nuclear receptor coactivator. (1399 aa)
LOC101386691Calmodulin-like; Belongs to the calmodulin family. (176 aa)
FKBP5Peptidylprolyl isomerase. (456 aa)
SRCTyrosine-protein kinase. (553 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3 isoform X1. (2674 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1208 aa)
LOC101381301LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like. (732 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
CALML5Calmodulin-like protein 5. (149 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
OPRM1Mu-type opioid receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (403 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
HSPA1LHeat shock 70 kDa protein 1-like isoform X1; Belongs to the heat shock protein 70 family. (661 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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