STRINGSTRING
CREB3 CREB3 NR5A1 NR5A1 CACNA1S CACNA1S NCEH1 NCEH1 PLCB3 PLCB3 STAR STAR POMC POMC ADCY3 ADCY3 KCNK3 KCNK3 CACNA1G CACNA1G ORAI1 ORAI1 SCARB1 SCARB1 CACNA1F CACNA1F KCNK2 KCNK2 GNAQ GNAQ ATF4 ATF4 CACNA1I CACNA1I PDE8A PDE8A PRKACA PRKACA LDLR LDLR CREB3L1 CREB3L1 PLCB2 PLCB2 NR4A1 NR4A1 LOC101384623 LOC101384623 CREB3L4 CREB3L4 CACNA1H CACNA1H ADCY9 ADCY9 PBX1 PBX1 AGT AGT CREB1 CREB1 SP1 SP1 CACNA1C CACNA1C LOC101384815 LOC101384815 ADCY8 ADCY8 PDE8B PDE8B CACNA1D CACNA1D KCNA4 KCNA4 PRKACB PRKACB GNAS GNAS LOC105757053 LOC105757053 CREB5 CREB5 PLCB1 PLCB1 ATF6B ATF6B LOC101381142 LOC101381142 ADCY2 ADCY2 MC2R MC2R ITPR2 ITPR2 LOC101378904 LOC101378904 CREB3L2 CREB3L2 NR0B1 NR0B1 GNA11 GNA11 ADCY5 ADCY5 ITPR1 ITPR1 ADCY6 ADCY6 ADCY4 ADCY4 MRAP MRAP AGTR1 AGTR1 ADCY7 ADCY7 ITPR3 ITPR3 ATF2 ATF2 ADCY1 ADCY1 PLCB4 PLCB4 LOC101364874 LOC101364874
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CREB3Cyclic AMP-responsive element-binding protein 3. (352 aa)
NR5A1Steroidogenic factor 1 isoform X1. (461 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
NCEH1Neutral cholesterol ester hydrolase 1 isoform X1. (408 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
POMCPro-opiomelanocortin. (258 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
KCNK3Potassium channel subfamily K member. (395 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2379 aa)
ORAI1LOW QUALITY PROTEIN: calcium release-activated calcium channel protein 1. (405 aa)
SCARB1Scavenger receptor class B member 1 isoform X1; Belongs to the CD36 family. (509 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1983 aa)
KCNK2Potassium channel subfamily K member 2 isoform X1; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (426 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2143 aa)
PDE8APhosphodiesterase. (835 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
LDLRLow-density lipoprotein receptor. (926 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (598 aa)
LOC101384623Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. (508 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (393 aa)
CACNA1HVoltage-dependent T-type calcium channel subunit alpha-1H. (2347 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
PBX1pre-B-cell leukemia transcription factor 1 isoform X1. (430 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
SP1Transcription factor Sp1 isoform X1. (786 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2190 aa)
LOC101384815Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
PDE8BPhosphodiesterase. (891 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
KCNA4Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (653 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (358 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1015 aa)
LOC105757053Neuroendocrine secretory protein 55. (246 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (369 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta isoform X2. (711 aa)
LOC101381142Steroid 21-hydroxylase; Belongs to the cytochrome P450 family. (492 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
MC2RAdrenocorticotropic hormone receptor. (297 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2639 aa)
LOC1013789043 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; Belongs to the 3-beta-HSD family. (373 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (519 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (470 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (301 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2758 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
MRAPMelanocortin-2 receptor accessory protein. (120 aa)
AGTR1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3 isoform X1. (2674 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
LOC101364874LOW QUALITY PROTEIN: cytochrome P450 11B1, mitochondrial-like; Belongs to the cytochrome P450 family. (402 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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