STRINGSTRING
ARRB1 ARRB1 CASR CASR CREB3 CREB3 MMP24 MMP24 PLD1 PLD1 GNAI1 GNAI1 PLCB3 PLCB3 GNA12 GNA12 SLC9A3R1 SLC9A3R1 FGFR1 FGFR1 PTH PTH NR4A2 NR4A2 ADCY3 ADCY3 VDR VDR ARAF ARAF GNAQ GNAQ MAPK3 MAPK3 ATF4 ATF4 HBEGF HBEGF EGR1 EGR1 BCL2 BCL2 GATA3 GATA3 PLD2 PLD2 ARRB2 ARRB2 PRKCB PRKCB PRKACA PRKACA PTH1R PTH1R RHOA RHOA GNAI2 GNAI2 FOS FOS CREB3L1 CREB3L1 PLCB2 PLCB2 MAPK1 MAPK1 SLC34A1 SLC34A1 LOC101363421 LOC101363421 MMP14 MMP14 SLC34A2 SLC34A2 MEF2D MEF2D CREB3L4 CREB3L4 ARHGEF11 ARHGEF11 ADCY9 ADCY9 MEF2C MEF2C GCM2 GCM2 JUND JUND PDE4C PDE4C PTHLH PTHLH TNFSF11 TNFSF11 CREB1 CREB1 MEF2A MEF2A GNA13 GNA13 SP1 SP1 GNAI3 GNAI3 SOST SOST AKAP13 AKAP13 RXRG RXRG RUNX2 RUNX2 PDE4D PDE4D PRKCG PRKCG ADCY8 ADCY8 GCM1 GCM1 LRP6 LRP6 PDE4B PDE4B MAFB MAFB PRKACB PRKACB MMP16 MMP16 GNAS GNAS LOC105757053 LOC105757053 CREB5 CREB5 MAP2K1 MAP2K1 TRPV5 TRPV5 PLCB1 PLCB1 LOC101363684 LOC101363684 ATF6B ATF6B ADCY2 ADCY2 PRKCA PRKCA ITPR2 ITPR2 KL KL FGF23 FGF23 MMP13 MMP13 LOC101384402 LOC101384402 CREB3L2 CREB3L2 SLC34A3 SLC34A3 MMP17 MMP17 BGLAP BGLAP GNA11 GNA11 RAF1 RAF1 MMP15 MMP15 ADCY5 ADCY5 PDE4A PDE4A ITPR1 ITPR1 NACA NACA ADCY6 ADCY6 ADCY4 ADCY4 MMP25 MMP25 ARHGEF1 ARHGEF1 ADCY7 ADCY7 ITPR3 ITPR3 ATF2 ATF2 ADCY1 ADCY1 CDKN1A CDKN1A RXRA RXRA BRAF BRAF PLCB4 PLCB4 LRP5 LRP5 EGFR EGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARRB1Beta-arrestin-1 isoform X1. (422 aa)
CASRExtracellular calcium-sensing receptor isoform X1. (1084 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (352 aa)
MMP24Matrix metalloproteinase-24. (573 aa)
PLD1Phospholipase. (1074 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (359 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12 isoform X1. (382 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2 isoform X1. (609 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
VDRVitamin D3 receptor. (427 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
BCL2Apoptosis regulator Bcl-2. (235 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
PLD2Phospholipase. (933 aa)
ARRB2Beta-arrestin-2 isoform X1. (420 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
PTH1RParathyroid hormone/parathyroid hormone-related peptide receptor; Belongs to the G-protein coupled receptor 2 family. (586 aa)
RHOATransforming protein RhoA isoform X1. (193 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform X1. (436 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
SLC34A1Sodium-dependent phosphate transport protein 2A. (639 aa)
LOC10136342125-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (508 aa)
MMP14Matrix metalloproteinase-14 isoform X1. (582 aa)
SLC34A2Sodium-dependent phosphate transport protein 2B. (709 aa)
MEF2DMyocyte-specific enhancer factor 2D isoform X1. (517 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (393 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1581 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X1. (483 aa)
GCM2Chorion-specific transcription factor GCMb. (525 aa)
JUNDLOW QUALITY PROTEIN: transcription factor jun-D. (464 aa)
PDE4CPhosphodiesterase. (694 aa)
PTHLHParathyroid hormone-related protein. (177 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
MEF2AMyocyte-specific enhancer factor 2A isoform X3. (496 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13 isoform X1. (377 aa)
SP1Transcription factor Sp1 isoform X1. (786 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
SOSTSclerostin. (213 aa)
AKAP13A-kinase anchor protein 13. (1429 aa)
RXRGRetinoic acid receptor RXR-gamma isoform X1. (463 aa)
RUNX2Runt-related transcription factor 2 isoform X2. (593 aa)
PDE4DPhosphodiesterase. (811 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
GCM1Chorion-specific transcription factor GCMa. (440 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
PDE4BPhosphodiesterase. (737 aa)
MAFBTranscription factor MafB. (323 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (358 aa)
MMP16Matrix metalloproteinase-16. (607 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1015 aa)
LOC105757053Neuroendocrine secretory protein 55. (246 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (369 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
TRPV5Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (732 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
LOC101363684Nascent polypeptide-associated complex subunit alpha. (215 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta isoform X2. (711 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2639 aa)
KLKlotho. (1010 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
MMP13Collagenase 3. (496 aa)
LOC1013844021,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial isoform X1; Belongs to the cytochrome P450 family. (514 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (519 aa)
SLC34A3Sodium-dependent phosphate transport protein 2C. (602 aa)
MMP17Matrix metalloproteinase-17. (595 aa)
BGLAPOsteocalcin; Binds strongly to apatite and calcium. (133 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (301 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
MMP15Matrix metalloproteinase-15. (673 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
PDE4APhosphodiesterase. (871 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2758 aa)
NACANascent polypeptide-associated complex subunit alpha. (201 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
MMP25Matrix metalloproteinase-25. (967 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (974 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3 isoform X1. (2674 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (161 aa)
RXRARetinoic acid receptor RXR-alpha isoform X1. (497 aa)
BRAFSerine/threonine-protein kinase B-raf. (772 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
LRP5Low-density lipoprotein receptor-related protein 5. (1451 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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