STRINGSTRING
MAPK10 MAPK10 SLC2A2 SLC2A2 HKDC1 HKDC1 CACNA1G CACNA1G MAPK3 MAPK3 PIK3CD PIK3CD PIK3CA PIK3CA SLC2A4 SLC2A4 HK2 HK2 CACNA1A CACNA1A LOC101378833 LOC101378833 IRS4 IRS4 MAPK1 MAPK1 PIK3R3 PIK3R3 MAFA MAFA SOCS1 SOCS1 HK3 HK3 PKLR PKLR PRKCE PRKCE INS INS PIK3R2 PIK3R2 SOCS4 SOCS4 CACNA1C CACNA1C PRKCZ PRKCZ IRS2 IRS2 IRS1 IRS1 MTOR MTOR CACNA1D CACNA1D INSR INSR KCNJ11 KCNJ11 MAPK9 MAPK9 PIK3CB PIK3CB ADIPOQ ADIPOQ PDX1 PDX1 TNF TNF PKM PKM IKBKB IKBKB PIK3R1 PIK3R1 SOCS3 SOCS3 CACNA1E CACNA1E SOCS2 SOCS2 MAPK8 MAPK8 PRKCD PRKCD ABCC8 ABCC8 LOC105758129 LOC105758129 HK1 HK1 GCK GCK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK10Mitogen-activated protein kinase. (464 aa)
SLC2A2Solute carrier family 2, facilitated glucose transporter member 2 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
HKDC1Putative hexokinase HKDC1. (917 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2379 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (508 aa)
HK2Hexokinase-2. (917 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2501 aa)
LOC101378833Insulin receptor substrate 2-like. (528 aa)
IRS4LOW QUALITY PROTEIN: insulin receptor substrate 4. (1307 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
MAFATranscription factor MafA. (358 aa)
SOCS1Suppressor of cytokine signaling 1. (216 aa)
HK3Hexokinase-3. (924 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (573 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2190 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa)
IRS2Insulin receptor substrate 2. (1327 aa)
IRS1Insulin receptor substrate 1. (1233 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2559 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2181 aa)
INSRTyrosine-protein kinase receptor. (1381 aa)
KCNJ11ATP-sensitive inward rectifier potassium channel 11. (390 aa)
MAPK9Mitogen-activated protein kinase. (427 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
ADIPOQAdiponectin isoform X1. (266 aa)
PDX1Pancreas/duodenum homeobox protein 1. (283 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (590 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2305 aa)
SOCS2LOW QUALITY PROTEIN: suppressor of cytokine signaling 2. (287 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
ABCC8ATP-binding cassette sub-family C member 8 isoform X1. (1580 aa)
LOC105758129Voltage-dependent N-type calcium channel subunit alpha-1B-like. (873 aa)
HK1Hexokinase-1 isoform X1. (935 aa)
GCKPhosphotransferase. (458 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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