STRINGSTRING
MAPK10 MAPK10 PLCG2 PLCG2 COL3A1 COL3A1 CXCL8 CXCL8 CCND1 CCND1 RELA RELA VEGFB VEGFB PLCB3 PLCB3 COL1A2 COL1A2 RAC1 RAC1 COL1A1 COL1A1 AKT1 AKT1 MMP2 MMP2 AKT2 AKT2 TGFB1 TGFB1 MAPK3 MAPK3 IL6 IL6 PIK3CD PIK3CD DIAPH1 DIAPH1 EGR1 EGR1 BCL2 BCL2 PIK3CA PIK3CA PRKCB PRKCB ICAM1 ICAM1 SERPINE1 SERPINE1 TGFB3 TGFB3 FOXO1 FOXO1 COL4A5 COL4A5 LOC101379802 LOC101379802 IL1B IL1B IL1A IL1A PLCB2 PLCB2 AKT3 AKT3 MAPK1 MAPK1 PIK3R3 PIK3R3 FN1 FN1 VCAM1 VCAM1 CDK4 CDK4 NFKB1 NFKB1 F3 F3 PLCD4 PLCD4 PRKCE PRKCE HRAS HRAS PIK3R2 PIK3R2 AGT AGT THBD THBD VEGFC VEGFC PLCD3 PLCD3 PRKCZ PRKCZ JAK2 JAK2 SMAD2 SMAD2 SELE SELE COL4A1 COL4A1 MAPK11 MAPK11 MAPK12 MAPK12 COL4A3 COL4A3 COL4A4 COL4A4 MAPK13 MAPK13 MAPK14 MAPK14 PIM1 PIM1 SMAD4 SMAD4 STAT5A STAT5A STAT3 STAT3 CDKN1B CDKN1B CDC42 CDC42 PLCE1 PLCE1 MAPK9 MAPK9 NOX4 NOX4 NFATC1 NFATC1 PIK3CB PIK3CB SMAD3 SMAD3 PLCB1 PLCB1 JUN JUN BAX BAX TNF TNF LOC101367134 LOC101367134 FIGF FIGF NOX1 NOX1 TGFB2 TGFB2 PRKCA PRKCA PIK3R1 PIK3R1 TGFBR2 TGFBR2 CCL2 CCL2 LOC101366544 LOC101366544 LOC105757317 LOC105757317 TGFBR1 TGFBR1 NRAS NRAS STAT1 STAT1 EDN1 EDN1 AGTR1 AGTR1 VEGFA VEGFA MAPK8 MAPK8 NOS3 NOS3 COL4A2 COL4A2 STAT5B STAT5B PLCG1 PLCG1 PLCD1 PLCD1 PRKCD PRKCD CASP3 CASP3 COL4A6 COL4A6 PLCB4 PLCB4 AGER AGER
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK10Mitogen-activated protein kinase. (464 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
COL3A1Collagen alpha-1(III) chain. (1466 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
RELATranscription factor p65. (539 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (188 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
COL1A2Collagen alpha-2(I) chain. (1367 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (211 aa)
COL1A1Collagen alpha-1(I) chain. (1460 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MMP272 kDa type IV collagenase. (661 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TGFB1Transforming growth factor beta-1. (287 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
IL6Interleukin-6 isoform X1. (212 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
DIAPH1Protein diaphanous homolog 1 isoform X1. (1284 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
BCL2Apoptosis regulator Bcl-2. (235 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ICAM1Intercellular adhesion molecule 1. (595 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
TGFB3Transforming growth factor beta-3. (461 aa)
FOXO1Forkhead box protein O1. (662 aa)
COL4A5Collagen alpha-5(IV) chain. (1673 aa)
LOC101379802Cytochrome b-245 heavy chain. (570 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (507 aa)
FN1Fibronectin isoform X1. (2476 aa)
VCAM1Vascular cell adhesion protein 1 isoform X1. (735 aa)
CDK4Cyclin-dependent kinase 4 isoform X1; Belongs to the protein kinase superfamily. (340 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (288 aa)
PLCD4Phosphoinositide phospholipase C. (775 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
HRASGTPase HRas isoform X1. (189 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (726 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
THBDThrombomodulin. (666 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (421 aa)
PLCD3Phosphoinositide phospholipase C. (778 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SELEE-selectin. (609 aa)
COL4A1Collagen alpha-1(IV) chain. (1669 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
COL4A3Collagen alpha-3(IV) chain. (1670 aa)
COL4A4Collagen alpha-4(IV) chain. (1686 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
CDC42Cell division control protein 42 homolog isoform X1. (191 aa)
PLCE1Phosphoinositide phospholipase C. (2301 aa)
MAPK9Mitogen-activated protein kinase. (427 aa)
NOX4NADPH oxidase 4 isoform X1. (578 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (823 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
JUNTranscription factor AP-1 isoform X1; Belongs to the bZIP family. (335 aa)
BAXApoptosis regulator BAX isoform X1. (192 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC101367134GTPase HRas-like. (177 aa)
FIGFVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (353 aa)
NOX1NADPH oxidase 1 isoform X1. (564 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
CCL2C-C motif chemokine. (101 aa)
LOC101366544LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like. (145 aa)
LOC105757317Mucin-1-like. (774 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
NRASGTPase NRas. (189 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
EDN1Endothelin-1 isoform X1. (227 aa)
AGTR1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (587 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1208 aa)
COL4A2Collagen alpha-2(IV) chain. (1762 aa)
STAT5BSignal transducer and activator of transcription. (818 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
PLCD1Phosphoinositide phospholipase C. (807 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (302 aa)
COL4A6Collagen alpha-6(IV) chain. (1685 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
AGERAdvanced glycosylation end product-specific receptor isoform X1. (381 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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